HIV-1 inhibitor-45
Based on 1 Customer Validation
HIV-1 inhibitor-45 is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity. HIV-1 inhibitor-45 shows poor cell permeability (with an apparent permeability coefficient (Papp) lower than 0.48 × 10−6 cm/s).
For research use only. We do not sell to patients.
- Purity: 99.54%
- CAS No.: 2677762-43-3
- Formula: C23H24N4O8S
- Molecular Weight:516.52
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
HIV-1 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | CC50 |
24.7 μM
Compound: IA-6
|
Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay
|
[PMID: 35780636] |
HIV-1 inhibitor-45 (compound IA-6) (5 d) has antiviral activity and low toxicity with CC50 value of 24.7 μM in MT-4 cells[1].
HIV-1 inhibitor-45 (compound IA-6) (Caco-2 cells) contributes to the poormembrane permeability by polyphenolic skeleton[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2677762-43-3
-
Appearance Solid
-
Molecular Weight 516.52
-
Formula C23H24N4O8S
-
Color White to off-white
-
SMILES
O=C(C1N(C(C2=CC(O)=C(O)C(O)=C2)=O)CCN(S(=O)(C3=CC=C(N)C=C3)=O)C1)NCC4=CC=CO4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (193.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9360 mL | 9.6802 mL | 19.3603 mL | 48.4008 mL |
| 5 mM | 0.3872 mL | 1.9360 mL | 3.8721 mL | 9.6802 mL | |
| 10 mM | 0.1936 mL | 0.9680 mL | 1.9360 mL | 4.8401 mL | |
| 15 mM | 0.1291 mL | 0.6453 mL | 1.2907 mL | 3.2267 mL | |
| 20 mM | 0.0968 mL | 0.4840 mL | 0.9680 mL | 2.4200 mL | |
| 25 mM | 0.0774 mL | 0.3872 mL | 0.7744 mL | 1.9360 mL | |
| 30 mM | 0.0645 mL | 0.3227 mL | 0.6453 mL | 1.6134 mL | |
| 40 mM | 0.0484 mL | 0.2420 mL | 0.4840 mL | 1.2100 mL | |
| 50 mM | 0.0387 mL | 0.1936 mL | 0.3872 mL | 0.9680 mL | |
| 60 mM | 0.0323 mL | 0.1613 mL | 0.3227 mL | 0.8067 mL | |
| 80 mM | 0.0242 mL | 0.1210 mL | 0.2420 mL | 0.6050 mL | |
| 100 mM | 0.0194 mL | 0.0968 mL | 0.1936 mL | 0.4840 mL |
HIV-1 inhibitor-45 Related Classifications
HY-150759 Related Classifications
Powered by Bioz