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Pathways Recommended: Vitamin D Related/Nuclear Receptor
Results for "

D-( )-Malic acid

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

1

Peptides

7

Natural
Products

7

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-20558
    D-(+)-Malic acid
    1 Publications Verification

    D-Malic acid

    		 Endogenous Metabolite Metabolic Disease
    D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport .
    D-(+)-Malic acid
  • HY-Y1311S
    Malic acid-d3

    Hydroxybutanedioic acid-d3; E 296-d3

    		 Endogenous Metabolite Others
    Malic acid-d3 is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods .
    Malic acid-d3
  • HY-137967
    Genistein 7-β-D-Glucuronide

    Genistein 7-O-glucuronide

    		 Drug Metabolite Metabolic Disease
    Genistein 7-β-D-Glucuronide (Genistein 7-O-glucuronide) is the primary phase II metabolite of Genistein (HY-14596) in human and rat hepatocytes. Genistein 7-β-D-Glucuronide undergoes distinct deconjugation in different functional assays. Genistein 7-β-D-Glucuronide is produced via hepatic microsomal glucuronidation and shows a mild age-related increase in intrinsic clearance in male F344 rats. Genistein 7-β-D-Glucuronide can be used for research on metabolism .
    Genistein 7-β-D-Glucuronide
  • HY-Y1069S
    (S)-Malic acid-d3
    1 Publications Verification

    (S)-Hydroxybutanedioic acid-d3; (S)-E 296-d3; L-Malic acid-d3

    		 Endogenous Metabolite Metabolic Disease
    (S)-Malic acid-d3 is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive .
    (S)-Malic acid-d3
  • HY-D0889R
    Glycylglycine (Standard)

    Gly-Gly (Standard); H-Gly-Gly-OH (Standard)

    		 Reference Standards Endogenous Metabolite Metabolic Disease
    Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
    Glycylglycine (Standard)
  • HY-Y0367S
    Maleic acid-d2

    Maleic-2,3-d2 acid

    		 Bacterial Endogenous Metabolite Infection
    Maleic Acid-d2 is the deuterium labeled Maleic Acid . Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes .
    Maleic acid-d2
  • HY-117081
    C30(ω-hydroxy) Ceramide (d18:1/30:0)

    		Others Others
    C30(ω-hydroxy) Ceramide (d18:1/30:0), a sphingolipid, is an epidermis-specifically vital component of the water barrier in mammalian skin. C30(ω-hydroxy) Ceramide (d18:1/30:0) is expressed in epidermal keratinocytes and male germ cells during their differentiation and maturation. C30(ω-hydroxy) Ceramide (d18:1/30:0) deficiency in the epiderm of Elovl4 deletion or mutation mice .
    C30(ω-hydroxy) Ceramide (d18:1/30:0)
  • HY-N6996S
    Methyl Eugenol-13C,d3

    		Isotope-Labeled Compounds Others
    Methyl Eugenol- 13C,d3 is the 13C- and deuterium labeled Methyl Eugenol. Methyl Eugenol, a phenylpropanoid chemical in leaves, fruits, stems, and/or roots, may be released when that corresponding part of a plant is damaged as a result of feeding by an herbivore. Methyl Eugenol is used for male annihilation of the oriental fruit fly .
    Methyl Eugenol-13C,d3
  • HY-145491
    Resolvin D5

    		ERK NF-κB CCR Inflammation/Immunology
    Resolvin D5 is an anti-inflammatory and analgesic agent produced in M2 macrophages. Resolvin D5 alleviates Paclitaxel (HY-B0015)-induced mechanical allodynia and inflammatory pain by activating the GPR32 receptor, with gender specificity (effective only in male mice) and independence from TRPV1 or TRPA1 channels. Resolvin D5 attenuates LPS-induced ERK phosphorylation and NF-κB nuclear translocation, downregulates proinflammatory mediators such as IL-6 and CCL5, inhibits Th17 cell differentiation and osteoclastogenesis, promotes regulatory T cell differentiation, and shows no cytotoxicity to human monocytes. The level of Resolvin D5 is elevated in arthritic SKG mice, but Resolvin D5 has no effect on dendritic cell differentiation or M1 macrophage polarization, nor does it prevent ZyA-induced arthritis progression. Resolvin D5 is suitable for research related to chemotherapy-induced peripheral neuropathy, inflammatory pain and rheumatoid arthritis .
    Resolvin D5
  • HY-59354S
    Maleic hydrazide-d2

    		DNA/RNA Synthesis Cancer
    Maleic hydrazide-d2 is the deuterium labeled Maleic hydrazide . Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .
    Maleic hydrazide-d2
  • HY-175640
    Troponin-IN-1

    		Pyroptosis Reactive Oxygen Species (ROS) Interleukin Related Caspase Cardiovascular Disease
    Troponin-IN-1 is a troponin inhibitor. Troponin-IN-1 protects OGD/R-injured H9c2 cardiomyocytes by reducing LDH leakage, pyroptosis and ROS accumulation. Troponin-IN-1 inhibits NO production and IL-1β/TNF-α/IL-18 release in LPS (HY-D1056)-induced RAW264.7 cells. Troponin-IN-1 acts via caspase-1/GSDMD/IL-18 pathway. Troponin-IN-1 reduces myocardial infarct size in LAD-induced myocardial ischemia/reperfusion (MI/R) male rats. Troponin-IN-1 can be used for the study of myocardial ischemia/reperfusion (MI/R) injury .
    Troponin-IN-1
  • HY-20558R
    D-(+)-Malic acid (Standard)

    D-Malic acid (Standard)

    		 Reference Standards Endogenous Metabolite Metabolic Disease
    D-(+)-Malic acid (Standard) is the analytical standard of D-(+)-Malic acid. This product is intended for research and analytical applications. D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport .
    D-(+)-Malic acid (Standard)
  • HY-32351B
    3-epi-Calcifediol

    3-epi-25-Hydroxy cholecalciferol

    		 PTHR Endocrinology
    3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
    3-epi-Calcifediol
  • HY-10847
    SB-277011

    SB-277011A

    		 Dopamine Receptor Endocrinology
    SB-277011 (SB-277011A) is a highly selective dopamine D3 receptor antagonist. SB-277011 induces ejaculation delay by inhibiting the expulsion phase of ejaculation, without impairing ejaculatory secretion or erectile function. SB-277011 also prolongs the post-ejaculatory refractory period. SB-277011 has no effect on the spontaneous preference of male rats for females in the sexually receptive phase. SB-277011 is widely applicable to studies related to premature ejaculation .
    SB-277011
  • HY-W673589
    Hexacosane, 2-Methyl-

    2-Me-C26

    		 Insecticide Infection
    2-Methylhexacosane is a saturated hydrocarbon and an insect pheromone. It has been found in the cuticle of M. dasystomus females, but not males, where it contributes to the mating behavior of males, as well as in D. melanogaster females where it modulates aggression of males towards females. 2-methylhexacosane has also been found in yellow jacket (V. vulgaris) trail extracts.
    Hexacosane, 2-Methyl-
  • HY-N15531
    Icariside D1

    		Estrogen Receptor/ERR Inflammation/Immunology Cancer
    Icariside D1 (Compound 9) is a flavonoid glycoside compound with antioxidant and anti-inflammatory activities, which is found in plants such as Epimedium. Icariside D1 is also a regulator of estrogen receptors. Icariside D1 is promising for research of osteoporosis, male infertility and female reproductive dysfunction and cancers .
    Icariside D1
  • HY-119069
    FAUC 3019

    		Dopamine Receptor Neurological Disease
    FAUC 3019 is a partial agonist of dopamine D(4) receptors and has the activity of promoting penile erection. FAUC 3019 has a strong stimulatory effect on penile erection in male rats at low concentrations. The biological activity of FAUC 3019 makes it a promising compound candidate .
    FAUC 3019
  • HY-32351BR
    3-epi-Calcifediol (Standard)

    3-epi-25-hydroxy Cholecalciferol (Standard)

    		 PTHR Reference Standards Endocrinology
    3-epi-Calcifediol (Standard) is the analytical standard of 3-epi-Calcifediol. This product is intended for research and analytical applications. 3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
    3-epi-Calcifediol (Standard)
  • HY-B2015S
    Carbosulfan-d18

    		Isotope-Labeled Compounds Parasite Insecticide Cholinesterase (ChE) Infection
    Carbosulfan-d18 is the deuterium labeled Carbosulfan. Carbosulfan is an orally active AChE inhibitor that hydrolyzes to Carbofuran in organisms to exert insecticidal effects. Carbosulfan exhibits broad-spectrum insecticidal activity, and it also induces severe oxidative stress by enhancing lipid peroxidation and impairing the antioxidant defense system. Carbosulfan causes reproductive toxicity in male rats and developmental disorders in their offspring. Carbosulfan shows persistence in paddy field environments and potential hazards to non-target organisms, and it is commonly used in studies related to reproductive toxicity and environmental risk assessment .
    Carbosulfan-d18
  • HY-116047S
    Anisylacetone-d5

    p-Methoxybenzylacetone-d5

    		 Isotope-Labeled Compounds Others Others
    Anisylacetone-d5 (p-Methoxybenzylacetone-d5) is deuterium labeled Anisylacetone. Anisylacetone (p-Methoxybenzylacetone) is a male fruit fly attractant .
    Anisylacetone-d5
  • HY-182381
    FLA-797

    		Dopamine Receptor Neurological Disease
    FLA-797 is a brain-penetrant dopamine D2 receptor blocker and very low affinity for dopamine D1 receptors. FLA-797 selectively binds to and blocks postsynaptic dopamine D2 receptors. FLA-797 induces catalepsy in male rats. FLA-797 blocks dopamine agonist-induced hypothermia in male rats. FLA-797 contributes marginally to the dopamine D2 receptor-blocking activity of Remoxipride (HY-101313) in male rats. FLA-797 does not mimic the atypical antipsychotic profile of Remoxipride. FLA-797 can be used for research on mental disorders .
    FLA-797
  • HY-131531A
    5-OH-DPAT

    5-Hydroxy-DPAT

    		 Dopamine Receptor Endocrinology
    5-OH-DPAT (5-Hydroxy-DPAT) is a potent and selective dopamine D2-receptor agonist lacking effects at 5-HT receptors. 5-OH-DPAT produces a moderate facilitation of the male rat sexual behavior .
    5-OH-DPAT
  • HY-131531B
    (R)-5-OH-DPAT

    (R)-5-Hydroxy-DPAT

    		 Drug Isomer Endocrinology
    (R)-5-OH-DPAT ((R)-5-Hydroxy-DPAT) is the R-enantiomer of 5-OH-DPAT (HY-131531A). 5-OH-DPAT is a weak antagonist of the dopamine D2 receptor (dopamine D2-receptor). 5-OH-DPAT moderately promotes sexual behavior in male rats .
    (R)-5-OH-DPAT
  • HY-N18905
    α-D-Glucosyl hesperidin

    		Apoptosis Bcl-2 Family Caspase SOD Endocrinology
    α-D-Glucosyl hesperidin is an orally effective structural modification derivative of Hesperidin (HY-15337) with anti-apoptotic (apoptosis) and antioxidant activities. α-D-Glucosyl hesperidin upregulates the expression of the Bcl-2 gene, while downregulating the expressions of the Bax and caspase-3 genes. α-D-Glucosyl hesperidin increases total antioxidant capacity, SOD and catalase levels, and decreases malondialdehyde and glutathione levels. α-D-Glucosyl hesperidin improves sperm motility, viability and plasma membrane function, while restoring reproductive organ weight and seminiferous tubule structure. α-D-Glucosyl hesperidin increases fertility index and exerts a synergistic protective effect with Proanthocyanidins (HY-N0794) in male rats with testicular ischemia-reperfusion injury. α-D-Glucosyl hesperidin can be used in the research of testicular ischemia-reperfusion injury .
    α-D-Glucosyl hesperidin

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