(S)-Malic acid-d3
Based on 1 publication(s) in Google Scholar
(S)-Malic acid-d3 is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive.
For research use only. We do not sell to patients.
- Purity: 99.64%
- CAS No.: 59652-74-3
- Formula: C4H3D3O5
- Molecular Weight:137.11
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (S)-Malic acid-d3
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 59652-74-3
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Unlabeled Cas 97-67-6
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Appearance Solid
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Molecular Weight 137.11
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Formula C4H3D3O5
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Color White to off-white
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SMILES
O=C(O)C([2H])([2H])[C@]([2H])(O)C(O)=O
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Synonyms
(S)-Hydroxybutanedioic acid-d3; (S)-E 296-d3; L-Malic acid-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
2024 Dec 30;9(1):367. PMID: 39737965
Solvent & Solubility
DMSO : 100 mg/mL (729.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (729.34 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Landete JM, et al. Requirement of the Lactobacillus casei MaeKR two-component system for L-malic acid utilization via a malic enzyme pathway. Appl Environ Microbiol. 2010 Jan;76(1):84-95. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 7.2934 mL | 36.4671 mL | 72.9341 mL | 182.3354 mL |
| 5 mM | 1.4587 mL | 7.2934 mL | 14.5868 mL | 36.4671 mL | |
| 10 mM | 0.7293 mL | 3.6467 mL | 7.2934 mL | 18.2335 mL | |
| 15 mM | 0.4862 mL | 2.4311 mL | 4.8623 mL | 12.1557 mL | |
| 20 mM | 0.3647 mL | 1.8234 mL | 3.6467 mL | 9.1168 mL | |
| 25 mM | 0.2917 mL | 1.4587 mL | 2.9174 mL | 7.2934 mL | |
| 30 mM | 0.2431 mL | 1.2156 mL | 2.4311 mL | 6.0778 mL | |
| 40 mM | 0.1823 mL | 0.9117 mL | 1.8234 mL | 4.5584 mL | |
| 50 mM | 0.1459 mL | 0.7293 mL | 1.4587 mL | 3.6467 mL | |
| 60 mM | 0.1216 mL | 0.6078 mL | 1.2156 mL | 3.0389 mL | |
| 80 mM | 0.0912 mL | 0.4558 mL | 0.9117 mL | 2.2792 mL | |
| 100 mM | 0.0729 mL | 0.3647 mL | 0.7293 mL | 1.8234 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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