Maleic acid-d2
Based on 1 Customer Validation
Maleic Acid-d2 is the deuterium labeled Maleic Acid. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
For research use only. We do not sell to patients.
- Purity: 98.35%
- CAS No.: 24461-33-4
- Formula: C4H2D2O4
- Molecular Weight:118.08
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 24461-33-4
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Unlabeled Cas 110-16-7
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Appearance Solid
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Molecular Weight 118.08
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Formula C4H2D2O4
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Color White to off-white
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SMILES
OC(/C([2H])=C([2H])\C(O)=O)=O
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Synonyms
Maleic-2,3-d2 acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : ≥ 100 mg/mL (846.88 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Fonda ML, et al. Glutamate decarboxylase. Substrate specificity and inhibition by carboxylic acids. Biochemistry. 1972 Mar 28;11(7):1304-9. [Content Brief]
[3]. Paudyal R, et al. A novel approach in acidic disinfection through inhibition of acid resistance mechanisms Maleic acid-mediated inhibition of glutamate decarboxylase activity enhances acid sensitivity of Listeria monocytogenes. Food Microbiol. 2018 Feb69:96-104. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.4688 mL | 42.3442 mL | 84.6883 mL | 211.7209 mL |
| 5 mM | 1.6938 mL | 8.4688 mL | 16.9377 mL | 42.3442 mL | |
| 10 mM | 0.8469 mL | 4.2344 mL | 8.4688 mL | 21.1721 mL | |
| 15 mM | 0.5646 mL | 2.8229 mL | 5.6459 mL | 14.1147 mL | |
| 20 mM | 0.4234 mL | 2.1172 mL | 4.2344 mL | 10.5860 mL | |
| 25 mM | 0.3388 mL | 1.6938 mL | 3.3875 mL | 8.4688 mL | |
| 30 mM | 0.2823 mL | 1.4115 mL | 2.8229 mL | 7.0574 mL | |
| 40 mM | 0.2117 mL | 1.0586 mL | 2.1172 mL | 5.2930 mL | |
| 50 mM | 0.1694 mL | 0.8469 mL | 1.6938 mL | 4.2344 mL | |
| 60 mM | 0.1411 mL | 0.7057 mL | 1.4115 mL | 3.5287 mL | |
| 80 mM | 0.1059 mL | 0.5293 mL | 1.0586 mL | 2.6465 mL | |
| 100 mM | 0.0847 mL | 0.4234 mL | 0.8469 mL | 2.1172 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Maleic acid-d2 Related Classifications
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