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DNase+I

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Bacterial (2) Biochemical Assay Reagents (1) DNA/RNA Synthesis (4) Endogenous Metabolite (2) Endonuclease (2) Environmental Pollutants (2) Phosphodiesterase (PDE) (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (4) Infection (3) Inflammation/Immunology (3) Metabolic Disease (4)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108882

DNase I, Bovine pancreas 25+ Cited Publications DNase	Others	Inflammation/Immunology Cancer
DNase I (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer .

HY-A0276

Gentamicin sulfate 60+ Cited Publications	Environmental Pollutants Antibiotic Bacterial	Infection Cancer
Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits *DNase I* with an IC₅₀ of 0.57 mM .

HY-A0276A

Gentamicin Maximum Cited Publications 64 Publications Verification	Environmental Pollutants Antibiotic Bacterial	Infection Cancer
Gentamicin, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibits *DNase I* with an IC₅₀ of 0.57 mM .

HY-108882A

*Recombinant DNase I* (RNase-free)** 25+ Cited Publications	Endonuclease	Others
Recombinant DNase I (RNase-free) is a recombinant deoxyribonuclease that degrades DNA. Recombinant DNase I is essential for limiting inflammatory responses and maintaining homeostasis .

HY-108882C

DNase I (filtered)	DNA/RNA Synthesis	Inflammation/Immunology
DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune reactions. Decreased DNase I activity may be associated with the occurrence and development of systemic lupus erythematosus (SLE). DNase I (filtered) is filtered through a 0.22 μM membrane and is not tested for pyrogenicity .

HY-108882B

DNase I RNase & Protease free 25+ Cited Publications	DNA/RNA Synthesis	Inflammation/Immunology
DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune responses. Decreased DNase I activity may be associated with the onset and progression of systemic lupus erythematosus (SLE). DNase I (RNase & Protease free) is a molecular biology-grade DNase I purified by chromatography to remove RNase and protease .

HY-162457

Mn007	DNA/RNA Synthesis	Infection
Mn007 is a potent inhibitor of bovine pancreatic DNase I, with the IC₅₀ of 45 μM, by forming molecular aggregation. Mn007 shows suppression of S. pyogenes growth in human whole blood .

HY-108882D

*Recombinant DNase I* Protease & RNase free, animal free**	DNA/RNA Synthesis	Others
Recombinant DNase I (Protease & RNase free, animal free) is a recombinant deoxyribonuclease that degrades DNA. Recombinant DNase I (Protease & RNase free, animal free) is essential for limiting inflammatory responses and maintaining homeostasis. This product is recombinant bovine pancreatic DNase I, purified by chromatography, free of animal-derived components, RNase and protease, and contains glycine as a stabilizer .

HY-P2878A

Phosphodiesterase l, Rattlesnake venom PDE, Rattlesnake venom	Phosphodiesterase (PDE)	Metabolic Disease
Phosphodiesterase l, Rattlesnake venom (PDE, Rattlesnake venom) is a non-selective phosphodiester bond hydrolase targeting phosphodiester bonds in oligonucleotides, catalyzing their hydrolysis into mononucleotides. Phosphodiesterase l, Rattlesnake venom cleaves phosphodiester linkages in DNA fragments digested by DNase I. Phosphodiesterase l, Rattlesnake venom is promising for research of nucleic acid structure and metabolism .

HY-176836

PNR-3-82	Endonuclease	Cancer
PNR-3-82 is a selective Apoptotic endonuclease G (EndoG) inhibitor with an IC₅₀ of 0.61  μM for EndoG over DNase I. PNR-3-82 does not inhibit five cell death-related enzymes including DNase II, RNase A, proteinase, lactate dehydrogenase and superoxide dismutase 1. PNR-3-82 has a cytoprotective activity and blocks Cisplatin (HY-17394) and Docetaxel (HY-B0011)-induced cell death. PNR-3-82 can be used for cell injuries research .

HY-RS20150

Dnase1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dnase1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dnase1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dnase1 Mouse Pre-designed siRNA Set A Dnase1 Mouse Pre-designed siRNA Set A

HY-E70940A

Sphingomyelinase, Streptomyces sp.	Endogenous Metabolite	Metabolic Disease
Sphingomyelinase, Streptomyces sp. (EC 3.1.4.12) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. Sphingomyelinase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide.

HY-E70940

Sphingomyelinase, Staphylococcus aureus	Endogenous Metabolite	Metabolic Disease
Sphingomyelinase, Staphylococcus aureus (EC 3.1.4.12) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. Sphingomyelinase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide.

HY-E70940B

Sphingomyelinase, Bacillus cereus	Biochemical Assay Reagents	Metabolic Disease
Sphingomyelinase, Bacillus cereus (EC 3.1.4.12) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. Sphingomyelinase, Bacillus cereus (EC 3.1.4.12) is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide.

Gentamicin sulfate 60+ Cited Publications	Structural Classification Classification of Application Fields Antibacterial Disease Research Other Antibiotics Plant agriculture research Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Animal Husbandry Mammalian Cell Culture Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Bacterial
Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits *DNase I* with an IC₅₀ of 0.57 mM .

Species:	Human (3) Mouse (1)
Tag:	His (3) GST (1)
Source:	HEK293 (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72974

	DNase I Protein, Human (HEK293, His) 5 Publications Verification Deoxyribonuclease-1; DNase I; Dornase alfa; DNASE1; DNL1; DRNI	Human	HEK293
	The DNase I protein is a serum endonuclease secreted by a variety of exocrine and endocrine organs and expressed in non-hematopoietic tissues. It preferentially selects protein-free DNA, plays a key role in apoptosis-induced cell death, and inhibits actin polymerization by specifically binding to G-actin. DNase I Protein, Human (HEK293, His) is the recombinant human-derived DNase I protein, expressed by HEK293 , with C-His labeled tag.

HY-P71543

	DNASE1L3 Protein, Human (GST) Deoxyribonuclease gamma; Deoxyribonuclease I like 3; Deoxyribonuclease I like III; Deoxyribonuclease I-like 3; DHP 2; DHP2; DNAS1L3; DNase gamma; DNase I homolog protein 2; DNase I homolog protein DHP2; DNase I like 3; DNase I-like 3; DNASE1L3; DNSL3_HUMAN; Liver and spleen DNase; LS DNase; LS-DNase; LSD; SLEB 16; SLEB16	Human	E. coli
	DNASE1L3 proteolytically cleaves single- and double-stranded DNA and generates fragments with 3'-OH termini. It can cleave chromatin, nucleosomes, and liposome-coated DNA. DNASE1L3 Protein, Human (GST) is the recombinant human-derived DNASE1L3 protein, expressed by E. coli , with N-GST labeled tag.

HY-P703079

	DNASE1L3 Protein, Human (His) Deoxyribonuclease gamma; Deoxyribonuclease I like 3; Deoxyribonuclease I like III; Deoxyribonuclease I-like 3; DHP 2; DHP2; DNAS1L3; DNase gamma; DNase I homolog protein 2; DNase I homolog protein DHP2; DNase I like 3; DNase I-like 3; DNASE1L3; DNSL3_HUMAN; Liver and spleen DNase; LS DNase; LS-DNase; LSD; SLEB 16; SLEB16	Human	E. coli
	DNASE1L3 proteolytically cleaves single- and double-stranded DNA and generates fragments with 3'-OH termini. It can cleave chromatin, nucleosomes, and liposome-coated DNA. DNASE1L3 Protein, Human (His) is the recombinant human-derived DNASE1L3 protein, expressed by E. coli , with C-10*His labeled tag.

HY-P790035

	DNase1L3 Protein, Mouse (His) 1 Publications Verification Dnase1l3Deoxyribonuclease gamma; DNase gamma; EC 3.1.21.-; DNase I homolog protein DHP2; Deoxyribonuclease I-like 3; DNase I-like 3; Liver and spleen DNase; LS-DNase; LSD	Mouse	E. coli
	DNase1L3 protein has DNA hydrolytic activity and can effectively cleave single-stranded and double-stranded DNA to generate 3'-OH terminal fragments. It cleaves chromatin into nucleosomal units and participates in internucleosomal DNA fragmentation during apoptosis and necrosis. DNase1L3 Protein, Mouse (His) is the recombinant mouse-derived DNase1L3 protein, expressed by E. coli , with C-6*His labeled tag.

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Dnase1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Dnase1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dnase1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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