Search Result

Results for "

EAAT1/SLC1A3 Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	EAAT (18) Akt (1) ASCT (3) Bcl-2 Family (2) Caspase (2) ERK (1) iGluR (2) NF-κB (1) Reference Standards (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (3) Cardiovascular Disease (3) Inflammation/Immunology (2) Neurological Disease (15)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Natural
Products

Antibodies

Oligonucleotides

Targets Recommended: EAAT Serpin URAT1 Oct3/4 Dopamine Transporter SLC39 (Zinc Transporter) Serotonin Transporter Apical Sodium-Dependent Bile Acid Transporter

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-107522

DL-TBOA 1 Publications Verification	EAAT	Neurological Disease
DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC₅₀s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), *EAAT2* and *EAAT3, respectively. DL-TBOA inhibits the uptake of [ ¹⁴C]glutamate in COS-1 cells expressing the human EAAT1* and *EAAT2* with K_i valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks *EAAT4* and *EAAT5* in a competitive manner with K_i values of 4.4 μM and 3.2 μM, respectively ^[1] .

HY-107661

Arundic Acid 2 Publications Verification ONO-2506; (R)-2-Propyloctanoic acid	ERK Akt NF-κB EAAT	Cardiovascular Disease Neurological Disease
Arundic Acid is an orally effective astrocyte function modulator and neuroprotective agent. Arundic Acid increases the expression and function of the astrocytic glutamate transporter *EAAT1* by activating the ERK, Akt and NF-κB pathways. Arundic Acid attenuates retinal ganglion cell death in a normal-tension glaucoma model. Arundic Acid exerts neuroprotective effects in a mouse model of Parkinson's disease. Arundic Acid is a S100β protein synthesis inhibitor that prevents neurological deficits and brain tissue damage after intracerebral hemorrhage in rats. Arundic Acid downregulates neuroinflammation and astrocytic dysfunction after status epilepticus in immature rats. Arundic Acid is applicable to research related to Parkinson's disease, cerebral ischemia, glaucoma, intracerebral hemorrhage and epilepsy ^[1] .

HY-10914

UCPH-101 1 Publications Verification	EAAT	Neurological Disease
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC₅₀ of 0.66 μM.

HY-107521

TFB-TBOA 3 Publications Verification CF3-Bza-TBOA	EAAT	Neurological Disease
TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that potently suppresses the activity of glial transporters. TFB-TBOA shows IC₅₀ values of 22, 17, and 300 nM for glutamate transporters EAAT1, EAAT2, and EAAT3 respectively in an uptake assay using cells transiently expressing EAATs .

HY-107523

WAY-213613 3 Publications Verification	EAAT	Neurological Disease
WAY-213613 is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC₅₀ value of 85 nM. WAY-213613 can be used for the research of central nervous system ^[1]

HY-101310

SYM 2081	iGluR EAAT Bcl-2 Family Caspase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of *EAAT1* (K_m of 54 μM). SYM 2081 inhibits *EAAT2*-mediated glutamate transport (K_b is 3.4 μM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression). SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain ^[1] .

HY-146242

SN05	EAAT ASCT	Cancer
SN05 is a potent amino acid transport (AAT) inhibitor with K_i values of 2.77 μM, 0.73 μM, 0.87 μM, 3.7 μM, 7.25 μM, 7.23 μM and 2.22 μM for *hASCT1, rASCT2, hASCT2, EAAT1, EAAT2, EAAC1* and *EAAT5*, respectively. SN05 can be used in the study of cancer ^[1].

HY-130125

*SLC1A1/EAAT3-IN-1*	EAAT	Neurological Disease
SLC1A1/EAAT3-IN-1 (Compound 3e) is a selective *EAAT3* inhibitor with an IC₅₀ of 7.2  μM for hEAAT3 over EAAT1,2,4 (IC₅₀: ∼ 250 μM). SLC1A1/EAAT3-IN-1 can be used for psychiatric disorders such as obsessive compulsive disorder and schizophrenia research ^[1].

HY-100801

L-threo-3-Hydroxyaspartic acid	EAAT	Neurological Disease
L-threo-3-Hydroxyaspartic acid is a potent *EAAT* inhibitor with K_is of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines ^[1].

HY-118858

UCPH-102	EAAT	Neurological Disease Cancer
UCPH-102 is a highly selective *EAAT1* inhibitor with an IC₅₀ of 0.43 µM. UCPH-102 exhibits a specific anti-proliferative effect on T-ALL cells. UCPH-102 also shows good blood-brain permeability, which can be used in studies of amyotrophic lateral sclerosis, Alzheimer’s disease, chronic pain and obsessive compulsive disorder ^[1] .

HY-107523A

WAY-213613 hydrochloride 3 Publications Verification	EAAT	Neurological Disease
WAY-213613 (hydrochloride) is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC₅₀ value of 85 nM. WAY-213613 can be used for the research of central nervous system ^[1].

HY-RS19528

Slc1a3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Slc1a3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Slc1a3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Slc1a3 Mouse Pre-designed siRNA Set A Slc1a3 Mouse Pre-designed siRNA Set A

HY-RS26023

Slc1a3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Slc1a3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc1a3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Slc1a3 Rat Pre-designed siRNA Set A Slc1a3 Rat Pre-designed siRNA Set A

HY-RS13054

SLC1A3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SLC1A3 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC1A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLC1A3 Human Pre-designed siRNA Set A SLC1A3 Human Pre-designed siRNA Set A

HY-146241

SN40	EAAT ASCT	Cancer
SN40 is a potent amino acid transport (AAT) inhibitor with K_is of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 can be used for researching anticancer ^[1].

HY-107522B

DL-TBOA ammonium	EAAT	Neurological Disease
DL-TBOA ammonium is a potent non-transportable inhibitor of excitatory amino acid transporters with IC₅₀s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), *EAAT2* and *EAAT3, respectively. DL-TBOA ammonium inhibits the uptake of [ ¹⁴C]glutamate in COS-1 cells expressing the human EAAT1* and *EAAT2* with K_i valuesof 42 μM and 5.7 μM, respectively. DL-TBOA ammonium blocks *EAAT4* and *EAAT5* in a competitive manner with K_i values of 4.4 μM and 3.2 μM, respectively ^[1] .

HY-146241B

SN40 hydrochloride	EAAT ASCT	Others
SN40 hydrochloride is a potent amino acid transport (AAT) inhibitor with K_is of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 hydrochloride can be used for researching anticancer ^[1].

HY-182941

Parawixin10	EAAT	Neurological Disease
Parawixin10 (Compound 2) is an N-acylpolyamine. Parawixin10 fails to enhance glutamate uptake in radioligand uptake assays of *EAAT1, EAAT2* or *EAAT3. Parawixin10 exhibits no positive allosteric modulatory activity in radioligand uptake assays of EAAT1−EAAT3*, nor can it improve neuronal survival rates in mice in a dose-dependent and statistically significant manner. Parawixin10 has no neuroprotective activity ^[1].

HY-100838

cis-α-(Carboxycyclopropyl)glycine L-CCG III	EAAT	Neurological Disease
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC₅₀: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na ⁺-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes ^[1] .

HY-101310R

SYM 2081 (Standard)	iGluR Reference Standards EAAT Bcl-2 Family Caspase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
SYM 2081 (Standard) is the analytical standard of SYM 2081 (HY-101310). This product is intended for research and analytical applications. SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of EAAT1 (Km of 54 μM). SYM 2081 inhibits EAAT2-mediated glutamate transport (Kb is 3.4 μM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression). SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain ^[1] .

HY-107523AR

WAY-213613 hydrochloride (Standard)	Reference Standards EAAT	Neurological Disease
WAY-213613 hydrochloride (Standard) is the analytical standard of WAY-213613 (hydrochloride) (HY-107523A). This product is intended for research and analytical applications. WAY-213613 (hydrochloride) is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC₅₀ value of 85 nM. WAY-213613 can be used for the research of central nervous system ^[1].

Cat. No.	Nombre del producto	Target	Research Area

HY-100838

cis-α-(Carboxycyclopropyl)glycine L-CCG III	EAAT	Neurological Disease
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC₅₀: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na ⁺-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes ^[1] .

L-threo-3-Hydroxyaspartic acid	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	EAAT
L-threo-3-Hydroxyaspartic acid is a potent *EAAT* inhibitor with K_is of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines ^[1].

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (1) IP (1) WB (2) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Nombre del producto	Application	Reactivity	Image

HY-P82734

	EAAT1 Antibody (YA2479) SLC1A3; EAAT1; GLAST; GLAST1; Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3	WB, IHC-P	Human, Mouse, Rat
	EAAT1 Antibody (YA2479) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EAAT1.

HY-P86606

	EAAT1 Antibody (YA6298) SLC1A3; EAAT1; GLAST; GLAST1; Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	EAAT1 Antibody (YA6298) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EAAT1.

Compare Products


Products	En stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / En stock - + Añadir al carrito Obtener un presupuesto

Slc1a3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Slc1a3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Slc1a3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Slc1a3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Slc1a3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc1a3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLC1A3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SLC1A3 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC1A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Consulta en línea

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Saludo			Country or Region *
Nombre del solicitante *			Nombre de la Organizaciòn *
Department *
Direcciòn del E-mail *			Nombre del producto *
Cat. No.			Requested quantity *
Número de teléfono *
Observaciones