L-threo-3-Hydroxyaspartic acid
Based on 1 Customer Validation
L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines.
For research use only. We do not sell to patients.
- Purity: 98.8%
- CAS No.: 7298-99-9
- Formula: C4H7NO5
- Molecular Weight:149.10
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Gut Microbial Metabolite Library
HY-L078
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Microbial Metabolite Library
HY-L084
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MCE Bioactive Compound Library
HY-L001V
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Non-natural Amino Acid Compound Library
HY-L198
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
Ki: 11 μM (EAAT1), 14 μM (EAAT3), 19 μM (EAAT2)[1]
Chemical Information
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CAS No. 7298-99-9
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Appearance Solid
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Molecular Weight 149.10
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Formula C4H7NO5
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Color White to off-white
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SMILES
N[C@@H]([C@H](O)C(O)=O)C(O)=O
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
1M NaOH : 14.91 mg/mL (100.00 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Hara R, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-Deficient Escherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolor A3(2). Appl Environ Microbiol. 2015 Jun;81(11):3648-54 [Content Brief]
[2]. Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67(11):2115-27. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1M NaOH | 1 mM | 6.7069 mL | 33.5345 mL | 67.0691 mL | 167.6727 mL |
| 5 mM | 1.3414 mL | 6.7069 mL | 13.4138 mL | 33.5345 mL | |
| 10 mM | 0.6707 mL | 3.3535 mL | 6.7069 mL | 16.7673 mL | |
| 15 mM | 0.4471 mL | 2.2356 mL | 4.4713 mL | 11.1782 mL | |
| 20 mM | 0.3353 mL | 1.6767 mL | 3.3535 mL | 8.3836 mL | |
| 25 mM | 0.2683 mL | 1.3414 mL | 2.6828 mL | 6.7069 mL | |
| 30 mM | 0.2236 mL | 1.1178 mL | 2.2356 mL | 5.5891 mL | |
| 40 mM | 0.1677 mL | 0.8384 mL | 1.6767 mL | 4.1918 mL | |
| 50 mM | 0.1341 mL | 0.6707 mL | 1.3414 mL | 3.3535 mL | |
| 60 mM | 0.1118 mL | 0.5589 mL | 1.1178 mL | 2.7945 mL | |
| 80 mM | 0.0838 mL | 0.4192 mL | 0.8384 mL | 2.0959 mL |
L-threo-3-Hydroxyaspartic acid Related Classifications
HY-100801 Related Classifications
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