L-threo-3-Hydroxyaspartic acid
Based on 1 Customer Validation
L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.8%
- CAS 番号: 7298-99-9
- 分子式: C4H7NO5
- 分子量:149.10
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
Ki: 11 μM (EAAT1), 14 μM (EAAT3), 19 μM (EAAT2)[1]
化学情報
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CAS 番号 7298-99-9
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性状 Solid
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分子量 149.10
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分子式 C4H7NO5
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Color White to off-white
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SMILES
N[C@@H]([C@H](O)C(O)=O)C(O)=O
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Structure Classification
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Initial Source
Escherichia coli
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
1M NaOH : 14.91 mg/mL (100.00 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (296 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
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- Español - ES (393 KB)
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- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Hara R, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-Deficient Escherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolor A3(2). Appl Environ Microbiol. 2015 Jun;81(11):3648-54 [Content Brief]
[2]. Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67(11):2115-27. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1M NaOH | 1 mM | 6.7069 mL | 33.5345 mL | 67.0691 mL | 167.6727 mL |
| 5 mM | 1.3414 mL | 6.7069 mL | 13.4138 mL | 33.5345 mL | |
| 10 mM | 0.6707 mL | 3.3535 mL | 6.7069 mL | 16.7673 mL | |
| 15 mM | 0.4471 mL | 2.2356 mL | 4.4713 mL | 11.1782 mL | |
| 20 mM | 0.3353 mL | 1.6767 mL | 3.3535 mL | 8.3836 mL | |
| 25 mM | 0.2683 mL | 1.3414 mL | 2.6828 mL | 6.7069 mL | |
| 30 mM | 0.2236 mL | 1.1178 mL | 2.2356 mL | 5.5891 mL | |
| 40 mM | 0.1677 mL | 0.8384 mL | 1.6767 mL | 4.1918 mL | |
| 50 mM | 0.1341 mL | 0.6707 mL | 1.3414 mL | 3.3535 mL | |
| 60 mM | 0.1118 mL | 0.5589 mL | 1.1178 mL | 2.7945 mL | |
| 80 mM | 0.0838 mL | 0.4192 mL | 0.8384 mL | 2.0959 mL |
L-threo-3-Hydroxyaspartic acid 関連分類
HY-100801 関連分類
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