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Cat. No.: HY-107523AR

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WAY-213613 hydrochloride (Standard)

WAY-213613 hydrochloride (Standard) is the analytical standard of WAY-213613 (hydrochloride) (HY-107523A). This product is intended for research and analytical applications. WAY-213613 (hydrochloride) is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC₅₀ value of 85 nM. WAY-213613 can be used for the research of central nervous system.

For research use only. We do not sell to patients.

CAS No.: 2450268-84-3
Formula: C₁₆H₁₄BrClF₂N₂O₄
Molecular Weight:451.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WAY-213613 hydrochloride (Standard) Chemical Structure

CAS No.: 2450268-84-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

IC50: 5004 nM (EAAT1); 85 nM (EAAT2); 3787 nM (EAAT3)^[1]

All EAAT Isoforms :

Chemical Information

CAS No. 2450268-84-3
Molecular Weight 451.65
Formula C₁₆H₁₄BrClF₂N₂O₄
SMILES

BrC(C=C(F)C(F)=C1)=C1OC2=CC=C(NC(C[C@H](N)C(O)=O)=O)C=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13. [Content Brief]

[2]. Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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WAY-213613 hydrochloride (Standard)

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Biological Activity
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Chemical Information
Purity & Documentation
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WAY-213613 hydrochloride (Standard)

All EAAT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

WAY-213613 hydrochloride (Standard) Related Classifications

HY-107523AR Related Classifications