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Cat. No.: HY-182941

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Parawixin10

Parawixin10 (Compound 2) is an N-acylpolyamine. Parawixin10 fails to enhance glutamate uptake in radioligand uptake assays of EAAT1, EAAT2 or EAAT3. Parawixin10 exhibits no positive allosteric modulatory activity in radioligand uptake assays of EAAT1−EAAT3, nor can it improve neuronal survival rates in mice in a dose-dependent and statistically significant manner. Parawixin10 has no neuroprotective activity.

For research use only. We do not sell to patients.

Formula: C₃₀H₅₅I₂N₉O₃
Molecular Weight:843.63

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Please store the product under the recommended conditions in the Certificate of Analysis.

Parawixin10 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[2]^[3]

EAAT1

EAAT2

EAAT3

All EAAT Isoforms :

In Vitro

Parawixin10 (1 nM-10 μM; 10 min) exerts no regulatory effect on the uptake of [³H]-D-Asp or [³H]-L-Glu in HEK293 cells expressing EAAT1 and EAAT2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 843.63
Formula C₃₀H₅₅I₂N₉O₃
SMILES

C[N+](C)(CCCC[N+](C)(C)CCCNC(CC1=CNC2=CC=CC(O)=C21)=O)CCCNC([C@H](CCCNC(N)=N)N)=O.[I-].[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Doroudian Y, et al. The N-Acylpolyamine Structure Assigned as Parawixin10 Does Not Display Positive Allosteric Modulatory Activity in EAAT1-3 Radioligand Uptake Assays, nor Does It Enhance Neuronal Survival in Mice in a Dose-Dependent and Statistically Significant Way. ACS Chem Neurosci. 2026;17(8):1530-1539. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Parawixin10

All EAAT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Parawixin10 Related Classifications

HY-182941 Related Classifications