2. Membrane Transporter/Ion Channel
  3. EAAT
  4. Parawixin10

Parawixin10 (Compound 2) is an N-acylpolyamine. Parawixin10 fails to enhance glutamate uptake in radioligand uptake assays of EAAT1, EAAT2 or EAAT3. Parawixin10 exhibits no positive allosteric modulatory activity in radioligand uptake assays of EAAT1−EAAT3, nor can it improve neuronal survival rates in mice in a dose-dependent and statistically significant manner. Parawixin10 has no neuroprotective activity.

For research use only. We do not sell to patients.

Parawixin10

Parawixin10 Chemical Structure

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Parawixin10 Related Antibodies

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Description

Parawixin10 (Compound 2) is an N-acylpolyamine. Parawixin10 fails to enhance glutamate uptake in radioligand uptake assays of EAAT1, EAAT2 or EAAT3. Parawixin10 exhibits no positive allosteric modulatory activity in radioligand uptake assays of EAAT1−EAAT3, nor can it improve neuronal survival rates in mice in a dose-dependent and statistically significant manner. Parawixin10 has no neuroprotective activity[1].

IC50 & Target[1][2][3]

EAAT1

 

EAAT2

 

EAAT3

 

In Vitro

Parawixin10 (1 nM-10 μM; 10 min) exerts no regulatory effect on the uptake of [3H]-D-Asp or [3H]-L-Glu in HEK293 cells expressing EAAT1 and EAAT2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parawixin10 Related Antibodies
Molecular Weight

843.63

Formula

C30H55I2N9O3
SMILES

C[N+](C)(CCCC[N+](C)(C)CCCNC(CC1=CNC2=CC=CC(O)=C21)=O)CCCNC([C@H](CCCNC(N)=N)N)=O.[I-].[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Parawixin10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Parawixin10Parawixin 10Parawixin-10EAATExcitatory amino acid transporter Glutamate transporter| C57BL/6J miceParawixia bistriataneuronal deathEAAT3HEK293 cellsprimary cortical mixed neuron-glia culturesglutamateEAAT1COS-7 cellsEAAT2Inhibitorinhibitorinhibit

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