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EETs

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By Targets:	Adrenergic Receptor (1) Calcium Channel (1) Cytochrome P450 (2) Drug Metabolite (1) Endogenous Metabolite (1) Epoxide Hydrolase (3) Isotope-Labeled Compounds (4) NF-κB (1) NOD-like Receptor (NLR) (2) PPAR (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (9) Endocrinology (1) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135795

1-Cyclohexyl-3-dodecyl urea CDU; N-Cyclohexyl-N-dodecyl urea; NCND	Epoxide Hydrolase	Cardiovascular Disease Metabolic Disease
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension .

HY-130494

(±)11(12)-EET 11,12-EET	NOD-like Receptor (NLR)	Cardiovascular Disease Inflammation/Immunology
(±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective .

HY-120954

14,15-EE-5(Z)-E	Others	Cardiovascular Disease
14,15-EE-5(Z)-E is a structural analogue of 14, 15-epoxide dicartrienoic acid (14,15-EET). 14,15-EE-5(Z)-E antagonizes the relaxation of vascular smooth muscle induced by EET .

HY-143294

sEH inhibitor-2	Epoxide Hydrolase	Cardiovascular Disease
sEH inhibitor-2 (compound 5l) is an orally active (predicted percentage absorption: 71.2-88.4%) soluble epoxide hydrolase (sEH) inhibitor, with an IC₅₀ of 0.9 nM. sEH inhibitor-2 can maintain epoxyeicosatrienoic acids (EETs) serum level in high concentrations. sEH inhibitor-2 can be used in study of cardiovascular protection .

HY-130494S

*(±)11(12)-EET-d11* (±)11,12-EET-d₁₁	NOD-like Receptor (NLR)	Cardiovascular Disease Inflammation/Immunology
(±)11(12)-EET-d₁₁ is the deuterium labeled (±)11(12)-EET. (±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective[1][2][3][4][6].

HY-139961S

(±)14(15)-EET-d11

Isotope-Labeled Compounds Others

(±)14(15)-EET-d₁₁ is the deuterium labeled (±)14(15)-EET[1].
HY-139937S

(±)14(15)-EET-d11 methyl ester

Isotope-Labeled Compounds Others

(±)14(15)-EET-d₁₁ methyl ester is the deuterium labeled (±)14(15)-EET methyl ester[1].
HY-139938S

(±)11(12)-EET-d11 methyl ester

Isotope-Labeled Compounds Others

(±)11(12)-EET-d₁₁ methyl ester is the deuterium labeled (±)11(12)-EET methyl ester[1].

*(±)14(15)-EET-d11*	Isotope-Labeled Compounds	Others
(±)14(15)-EET-d₁₁ is the deuterium labeled (±)14(15)-EET[1].

*(±)14(15)-EET-d11 methyl ester*	Isotope-Labeled Compounds	Others
(±)14(15)-EET-d₁₁ methyl ester is the deuterium labeled (±)14(15)-EET methyl ester[1].

*(±)11(12)-EET-d11 methyl ester*	Isotope-Labeled Compounds	Others
(±)11(12)-EET-d₁₁ methyl ester is the deuterium labeled (±)11(12)-EET methyl ester[1].

HY-151616

sEH inhibitor-10	Epoxide Hydrolase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
sEH inhibitor-10 (Compound 37) is a selective soluble epoxide hydrolase (sEH) inhibitor (IC₅₀=0.5 μM). sEH inhibitor-10 maintains high cycloeicosatrienoic acid (EETs) levels by inhibiting sEH, thereby reducing inflammation, regulating endothelial tone, improving mitochondrial function, and reducing oxidative stress. sEH inhibitor-10 has good research potential in metabolic, renal and cardiovascular diseases .

HY-131721

*14,15-EET-SI*	Others	Others
14,15-EET-SI is a sulfonimide (SI) analog metabolized from 14,15-EET, which is also an effective mitogen. 14,15-EET-SI can stimulate the incorporation of [3H] thymidine, activate pp60c-src and initiate the tyrosine kinase cascade, mediating their mitotic effects. Additionally, 14,15-EET-SI can increase cell proliferation as well as the expression of c-fos and egr-1 mRNA .

HY-150092S

(2S,3R)-8(9)-EET-d11

Isotope-Labeled Compounds Drug Metabolite Others

(2S,3R)-8(9)-EET-d₁₁ is deuterium-labeled (2S,3R)-8(9)-EET (HY-150092) .

*(2S,3R)-8(9)-EET-d11*	Isotope-Labeled Compounds Drug Metabolite	Others
(2S,3R)-8(9)-EET-d₁₁ is deuterium-labeled (2S,3R)-8(9)-EET (HY-150092) .

HY-130229

(±)5,6-DHET lactone (±)5,6-DiHETrE lactone	Others	Cardiovascular Disease
5,6-DiHET lactone ((±)5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME.

HY-113489

14,15-Epoxyeicosatrienoic acid 14,15-EET	Endogenous Metabolite	Cardiovascular Disease Neurological Disease
14,15-Epoxyeicosatrienoic acid (14,15-EET) is a metabolite of Arachidonic acid (HY-109590). 14,15-Epoxyeicosatrienoic acid is a potent inhibitor of in vivo platelet aggregation. 14,15-Epoxyeicosatrienoic acid facilitates astrocytic Aβ clearance. 14,15-Epoxyeicosatrienoic acid can be used for Alzheimer's Disease research .

HY-150084

(±)14,15-Epoxyeicosatrienoic acid (±)14(15)-EET	Cytochrome P450	Cancer
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth .

HY-N0515

Ophiopogonin D	PPAR NF-κB Calcium Channel	Cardiovascular Disease Inflammation/Immunology
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

HY-114759

MS-PPOH	Cytochrome P450	Neurological Disease Metabolic Disease Cancer
MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor . MS-PPOH inhibits CYP2C8 and CYP2C9 with IC₅₀s of 15 and 11 μM, respectively . MS-PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-132184

5,6-Epoxyeicosatrienoic acid 5,6-EET; (±)5,6-EpETrE	Adrenergic Receptor	Endocrinology
5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC₅₀=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5,6-Epoxyeicosatrienoic acid is provided as a mixture of the free acid and lactone.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0515

Ophiopogonin D	Cardiovascular Disease Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Steroids	PPAR NF-κB Calcium Channel
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

HY-150084

(±)14,15-Epoxyeicosatrienoic acid (±)14(15)-EET	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Cytochrome P450
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth .

Cat. No.	Product Name	Chemical Structure

HY-130494S

*(±)11(12)-EET-d11*
(±)11(12)-EET-d₁₁ is the deuterium labeled (±)11(12)-EET. (±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective[1][2][3][4][6].

HY-139961S

(±)14(15)-EET-d11

(±)14(15)-EET-d₁₁ is the deuterium labeled (±)14(15)-EET[1].
HY-139937S

(±)14(15)-EET-d11 methyl ester

(±)14(15)-EET-d₁₁ methyl ester is the deuterium labeled (±)14(15)-EET methyl ester[1].
HY-139938S

(±)11(12)-EET-d11 methyl ester

(±)11(12)-EET-d₁₁ methyl ester is the deuterium labeled (±)11(12)-EET methyl ester[1].
HY-150092S

(2S,3R)-8(9)-EET-d11

(2S,3R)-8(9)-EET-d₁₁ is deuterium-labeled (2S,3R)-8(9)-EET (HY-150092) .

*(±)14(15)-EET-d11*
(±)14(15)-EET-d₁₁ is the deuterium labeled (±)14(15)-EET[1].

*(±)14(15)-EET-d11 methyl ester*
(±)14(15)-EET-d₁₁ methyl ester is the deuterium labeled (±)14(15)-EET methyl ester[1].

*(±)11(12)-EET-d11 methyl ester*
(±)11(12)-EET-d₁₁ methyl ester is the deuterium labeled (±)11(12)-EET methyl ester[1].

*(2S,3R)-8(9)-EET-d11*
(2S,3R)-8(9)-EET-d₁₁ is deuterium-labeled (2S,3R)-8(9)-EET (HY-150092) .

MS-PPOH		Alkynes
MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor . MS-PPOH inhibits CYP2C8 and CYP2C9 with IC₅₀s of 15 and 11 μM, respectively . MS-PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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EETs

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products