1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. MS-PPOH

MS-PPOH 

Cat. No.: HY-114759
Handling Instructions

MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor. MS-PPOH inhibits CYP2C8 and CYP2C9 with IC50s of 15 and 11 µM, respectively.

For research use only. We do not sell to patients.

MS-PPOH Chemical Structure

MS-PPOH Chemical Structure

CAS No. : 206052-02-0

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Description

MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor[1]. MS-PPOH inhibits CYP2C8 and CYP2C9 with IC50s of 15 and 11 µM, respectively[2].

In Vitro

MS-PPOH blocks cellular EET synthesis. MS-PPOH inhibits tonic (basal) cell invasion and migration and reduces the 11,12-EET (1.0 μM)-induced cell motility[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PC-3 cells
Concentration: 2.0 and 10.0 μM
Incubation Time: 24 hours
Result: Inhibited tonic (basal) cell invasion and migration.
In Vivo

MS-PPOH (20 mg/kg/day, i.v.) for 6 days significantly reduced renal levels of epoxyeicosatrienoic acids (EETs) in Dahl salt-resistant rats on 2% NaCl drinking solution[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male stroke-prone spontaneously hypertensive rats (SHRSP)[3]
Dosage: 20 mg/kg/day
Administration: Intravenously
Result: Treatment had negligible effects on systolic blood pressure (SBP) in saline-drinking SHRSP after 1 week, 160 vs. 167 mmHg, or 2 weeks of treatment, 171 vs. 175 mmHg, for vehicle vs. MS-PPOH, respectively.
Molecular Weight

323.41

Formula

C₁₆H₂₁NO₄S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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MS-PPOH
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HY-114759
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