206052-02-0
206052-02-0
Chemical Structure
MS-PPOH
- CAS No.: 206052-02-0
- Formula:C16H21NO4S
- Molecular Weight:323.41
IUPAC Name: N-(methylsulfonyl)-6-(2-(prop-2-yn-1-yloxy)phenyl)hexanamide
InChIKey: REUHFEYPDFRRGJ-UHFFFAOYSA-N
SMILES: O=C(NS(=O)(C)=O)CCCCCC1=CC=CC=C1OCC#C
Biological Activity: MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor[1]. MS-PPOH inhibits CYP2C8 and CYP2C9 with IC50s of 15 and 11 μM, respectively[2]. MS-PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MS-PPOH | 99.05% | MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor. MS-PPOH inhibits CYP2C8 and CYP2C9 with IC50s of 15 and 11 μM, respectively. MS-PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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References
- [1]. Kasem Nithipatikom, et al. Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists. Cancer Sci. 2010 Dec;101(12):2629-36. [Content Brief]
- [2]. Jun Yang, et al. Cytochrome P450 2C24: Expression, Tissue Distribution, High-Throughput Assay, and Pharmacological Inhibition. Acta Pharm Sin B. 2012 Apr;2(2):137-145. [Content Brief]
