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5,6-Epoxyeicosatrienoic acid-d11

(Synonyms: 5,6-EET-d11; (±)5,6-EpETrE-d11)

5,6-Epoxyeicosatrienoic acid-d11 (5,6-EET-d11) is deuterium labeled 5,6-Epoxyeicosatrienoic acid. 5,6-Epoxyeicosatrienoic acid is one of the four major epoxyeicosatrienoic acid (EET) isomers metabolized from Arachidonic acid (HY-109590). 5,6-Epoxyeicosatrienoic acid induces peripheral vasodilation and lowers blood pressure by inhibiting T-type calcium channels (Cav3.2: IC50 = 0.54 μM). 5,6-Epoxyeicosatrienoic acid causes vasoconstriction in hypoxic pulmonary blood vessels via activating Rho kinase in a membrane depolarization-dependent manner. 5,6-Epoxyeicosatrienoic acid induces mechanical pain by activating TRPA1. 5,6-Epoxyeicosatrienoic acid can be used in studies related to hypoxic pulmonary vasoconstriction, mechanical hyperalgesia and hypertension.

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  • CAS No.: 1881277-30-0
  • Formula: C20H21D11O3
  • Molecular Weight:331.53
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • 5,6-Epoxyeicosatrienoic acid-d11 Chemical Structure
    5,6-Epoxyeicosatrienoic acid-d11 Chemical Structure
CAS No.: 1881277-30-0
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    5,6-Epoxyeicosatrienoic acid-d11 Chemical Structure
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  • 5,6-Epoxyeicosatrienoic acid-d11