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EP4 prostaglandin receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Prostaglandin Receptor (32) Drug Metabolite (1) Endogenous Metabolite (6) Fungal (1) Interleukin Related (1) Isotope-Labeled Compounds (3) PPAR (2) Reference Standards (4) STAT (1) TGF-beta/Smad (2)
By Research Areas:	Cancer (10) Cardiovascular Disease (6) Endocrinology (20) Infection (1) Inflammation/Immunology (10) Metabolic Disease (5) Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Prostaglandin Receptor PGE synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0131

Prostaglandin E1 20+ Cited Publications Alprostadil; PGE1	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, *EP4, EP2, IP and EP1, respectively. Prostaglandin* E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-16781

Grapiprant 4 Publications Verification CJ-023423; RQ-00000007; AAT-007	Prostaglandin Receptor	Metabolic Disease Endocrinology Cancer
Grapiprant (CJ-023423) is a selective **EP4 receptor** antagonist whose physiological ligand is prostaglandin E₂ (PGE₂). Grapiprant displaces [ ³H]-PGE₂ (1 nM) binding to dog recombinant **EP4 receptor with IC₅₀ value of 35 nM and K_i** value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment ^[3].

HY-128686

KAG-308 3 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
KAG-308 is a potent selective and orally active agonist of **EP4 receptor** (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a K_i and an EC₅₀ of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor .

HY-114974

Rivenprost ONO-4819; ONO-AE1-734	Prostaglandin Receptor	Others Inflammation/Immunology
Rivenprost (ONO-4819; ONO-AE1-734) is a selective agonist for prostaglandin E receptor *EP4* with K_i of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects .

HY-113205

15-keto-Prostaglandin E2 15-keto-PGE2	Endogenous Metabolite Prostaglandin Receptor STAT PPAR Fungal Drug Metabolite	Cardiovascular Disease Infection Endocrinology Cancer
15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE₂ metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and *EP4* receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier .

HY-100448A

Butaprost 2 Publications Verification	Prostaglandin Receptor TGF-beta/Smad	Endocrinology
Butaprost is a selective prostaglandin E receptor (EP2) agonist with an EC₅₀ of 33 nM and a K_i of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering TGF-β/Smad2 signalling .

HY-10797

CJ-42794 4 Publications Verification CJ-042794	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
CJ-42794 (CJ-042794) is a potent, orally active, selective **prostaglandin E receptor 4 (EP4) antagonist with an IC₅₀ value of 10 nM, which is 200-fold more selective than EP1, EP2 and EP3**. CJ-42794 can be used in research of gastric ulcers .

HY-14899

Taprenepag 4 Publications Verification CP-544326	Prostaglandin Receptor	Endocrinology
Taprenepag (CP-544326) is a potent and selective prostaglandin EP(2) agonist with IC₅₀s of 10 and 15 nM for human and rat EP2, respectively. Taprenepag shows selectivity for EP2 over other EP receptors (IC50s>3200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors .

HY-135259

CAY10580	Prostaglandin Receptor	Metabolic Disease
CAY10580 is a potent and selective prostaglandin **EP₄ receptor agonist (K_i**=35 nM) .

HY-122168

AAT-008	Prostaglandin Receptor	Inflammation/Immunology Cancer
AAT-008 is a potent, selective, and orally active prostaglandin **EP4 receptor antagonist with K_i*s of 0.97 and 6.1 nM for recombinant human EP4* and recombinant rat EP4, respectively. AAT-008 exerts tumor growth delay in mice bearing CT26WT colon tumors when combined with radiotherapy. AAT-008 can be used for the study of acute and chronic inflammatory pain and cancer .

HY-111539

BAY-1316957	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
BAY-1316957 is a potent, selective and orally active **prostaglandin E2 receptor subtype 4 (EP4-R) antagonist with an IC₅₀** of 15.3 nM for human EP4-R. BAY-1316957 has excellent agent metabolism and pharmacokinetics properties, and can be used for endometriosis research .

HY-112152

GSK726701A	Prostaglandin Receptor	Neurological Disease Inflammation/Immunology Endocrinology
GSK726701A is a novel **prostaglandin E2 receptor 4 (EP4) partial agonist with a pEC₅₀** of 7.4.

HY-169859

EP4 receptor antagonist 7	Prostaglandin Receptor Interleukin Related	Inflammation/Immunology Cancer
EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC₅₀ value of 1.1 nM. EP4 receptor antagonist 7 inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC₅₀ value of 0.9 nM. EP4 receptor antagonist 7 decreases PGE2-induced expression of mRNA encoding IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. EP4 receptor antagonist 7 combined with an anti-PD-1 antibody inhibits tumor growth and increases infiltration of CD ⁸⁺ T cells into tumors in a CT26 murine colon cancer model .

HY-120973

Butaprost free acid	Prostaglandin Receptor TGF-beta/Smad	Endocrinology
Butaprost free acid is a selective prostaglandin E receptor (EP2) agonist with an EC₅₀ of 33 nM and a K_i of 2.4 μM for murine EP2 receptor. Butaprost free acid is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid attenuates fibrosis by hampering TGF-β/Smad2 signalling .

HY-116099

ER-819762	Prostaglandin Receptor	Inflammation/Immunology
ER-819762 is an orally active, highly selective prostaglandin E₂ (PGE₂) **EP₄ receptor antagonist with an EC₅₀** of 70 nM against human EP₄ receptor. ER-819762 can be used for rheumatoid arthritis research .

HY-B0131R

Prostaglandin E1 (Standard) Alprostadil(Standard); PGE1 (Standard)	Reference Standards Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-163651

(R)-Vorbipiprant (R)-CR6086	Prostaglandin Receptor	Inflammation/Immunology
(R)-Vorbipiprant ((R)-CR6086) is an orally active antagonist for prostaglandin E2 receptor 4 (EP4) with K_i of 16.6 nM for human EP4. (R)-Vorbipiprant inhibits PGE2 (HY-101952)-induced cAMP production with an IC₅₀ of 22 nM. (R)-Vorbipiprant exhibits immunomodulatory and anti-angiogenic activities, and ameliorates the collagen-induced arthritis in mice .

HY-16781R

Grapiprant (Standard) CJ-023423 (Standard); RQ-00000007 (Standard); AAT-007 (Standard)	Prostaglandin Receptor Reference Standards	Metabolic Disease Endocrinology Cancer
Grapiprant (Standard) is the analytical standard of Grapiprant. This product is intended for research and analytical applications. Grapiprant (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor with IC50 value of 35 nM and Ki value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment .

HY-118190

AL 8810 methyl ester	Prostaglandin Receptor	Endocrinology
AL 8810 methyl ester is a prostaglandin F(2α) analog and a prostaglandin F(2α) receptor agonist. Can competitively antagonize the effects of the FP receptor agonist Fluprostenol (HY-108560). AL 8810 methyl ester has no significant potency against TP, DP, EP(2), EP(4) receptor subtypes in cell lines .

HY-114822

Prostaglandin A3 PGA3	Prostaglandin Receptor PPAR	Endocrinology
Prostaglandin A3 is a non-enzymatic dehydration product of prostaglandin E3 (PGE3). Prostaglandin A3 showed good affinity for canine EP2 and EP4 receptors with IC₅₀ values of 120 and 20 nM, respectively. The K_i value of Prostaglandin A3 for human PPARγ was 188 μM .

HY-114910

11-Deoxy Prostaglandin E2	Prostaglandin Receptor	Cancer
11-Deoxy Prostaglandin E2 is a selective agonist of *EP4* with an EC₅₀ of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions .

HY-B0131S2

Prostaglandin E1-d9 Alprostadil-d₉; PGE1-d₉	Isotope-Labeled Compounds Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-B0131A

Alprostadil sodium	Prostaglandin Receptor	Cardiovascular Disease
Alprostadil sodium is a prostaglandin receptor ligand that exhibits Ki values of 36, 10, 1.1, 2.1, and 33 nM for the EP1, EP2, EP3, EP4, and IP receptors in mice, respectively. It promotes vasodilation and inhibits platelet aggregation, making it a useful vasodilator for investigating peripheral vascular disease.

HY-B0131S

Prostaglandin E1-d4	Isotope-Labeled Compounds Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E1-d₄ is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-W007888R

2-Hydroxy-4-methylbenzaldehyde (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-183845

HTL0039732	Prostaglandin Receptor	Cancer
HTL0039732 is an orally active antagonist of the prostaglandin EP4 receptor (Prostaglandin E2 Receptor EP4). HTL0039732 reverses PGE₂-induced differentiation toward M2-like macrophages. HTL0039732 exhibits efficacy in syngeneic tumor models and acts synergistically with PD-1/PD-L1 pathway blockers. HTL0039732 can be used for the research of advanced solid tumors .

HY-129922

16(R)-AFP 07 free acid	Prostaglandin Receptor	Endocrinology
Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki=0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4. 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated.

HY-115827

AH22921	Prostaglandin Receptor	Others
AH22921 is an EP4 prostaglandin receptor antagonist with the activity of antagonizing the activation of adenylate cyclase by prostaglandins in CHO cells. AH22921 can shift the PGE2 concentration-response curve to the right in CHO cells. It is a non-competitive antagonist that is selective for EP4 receptors and has an antagonistic effect on EP4 receptors in CHO cells, but does not affect the PGE2 concentration-response curve in NPE cells containing EP2 receptors.

HY-185643

PF-04475270	Prostaglandin Receptor	Neurological Disease
PF-04475270 is a prodrug of CP-734432 (HY-119236), as well as an agonist of the **EP4 prostaglandin receptor, with IC₅₀ values of 2 nM and 8 nM against human and canine sources, respectively. PF-04475270 is rapidly hydrolyzed into its active metabolite CP-734432 by ocular esterases or corneal homogenate, stimulates cAMP production, and activates cAMP response element-mediated β-lactamase** activity in cells expressing EP4. PF-04475270 can be used in research related to glaucoma .

HY-105315

AFP-07	Prostaglandin Receptor	Endocrinology
AFP-07 is a derivative of 7, 7-difluoroprostacyclic and is a highly potent and selective prostacyclin receptor IP receptor agonist with a K_i value of 0.561 nM .

HY-129293

AFP-07 free acid	Prostaglandin Receptor	Endocrinology
AFP-07 free acid is a derivative of 7, 7-difluoroprostacyclic and is a highly potent and selective prostacyclin receptor IP receptor agonist with a K_i value of 0.561 nM .

HY-16781S

Grapiprant-d4 CJ-023423-d₄; RQ-00000007-d₄; AAT-007-d₄	Isotope-Labeled Compounds Prostaglandin Receptor	Metabolic Disease Cancer
Grapiprant-d₄ (CJ-023423-d₄) is the deuterium labeled Grapiprant (HY-16781). Grapiprant (CJ-023423) is a selective **EP4 receptor** antagonist whose physiological ligand is prostaglandin E₂ (PGE₂). Grapiprant displaces [ ³H]-PGE₂ (1 nM) binding to dog recombinant **EP4 receptor with IC₅₀ value of 35 nM and K_i** value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment ^[3].

HY-10797R

CJ-42794 (Standard) CJ-042794 (Standard)	Reference Standards Prostaglandin Receptor	Inflammation/Immunology Endocrinology
CJ-42794 (Standard) is the analytical standard of CJ-42794 (HY-10797). This product is intended for research and analytical applications. CJ-42794 (CJ-042794) is a potent, orally active, selective prostaglandin E receptor 4 (EP4) antagonist with an IC₅₀ value of 10 nM, which is 200-fold more selective than EP1, EP2 and EP3. CJ-42794 can be used in research of gastric ulcers .

Butaprost free acid	Biochemical Assay Reagents
Butaprost free acid is a selective prostaglandin E receptor (EP2) agonist with an EC₅₀ of 33 nM and a K_i of 2.4 μM for murine EP2 receptor. Butaprost free acid is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid attenuates fibrosis by hampering TGF-β/Smad2 signalling .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0131

Prostaglandin E1 20+ Cited Publications Alprostadil; PGE1	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, *EP4, EP2, IP and EP1, respectively. Prostaglandin* E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-113205

15-keto-Prostaglandin E2 15-keto-PGE2	Structural Classification Ketones, Aldehydes, Acids Marine algae Marine natural products Source Classification	Endogenous Metabolite Prostaglandin Receptor STAT PPAR Fungal Drug Metabolite
15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE₂ metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and *EP4* receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier .

HY-B0131R

Prostaglandin E1 (Standard) Alprostadil(Standard); PGE1 (Standard)	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Reference Standards Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-W007888R

2-Hydroxy-4-methylbenzaldehyde (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

Cat. No.	Product Name	Chemical Structure

HY-B0131S2

Prostaglandin E1-d9
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-B0131S

Prostaglandin E1-d4
Prostaglandin E1-d₄ is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

Prostaglandin E1-d4

Prostaglandin E1-d₄ is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-16781S

Grapiprant-d4
Grapiprant-d₄ (CJ-023423-d₄) is the deuterium labeled Grapiprant (HY-16781). Grapiprant (CJ-023423) is a selective **EP4 receptor** antagonist whose physiological ligand is prostaglandin E₂ (PGE₂). Grapiprant displaces [ ³H]-PGE₂ (1 nM) binding to dog recombinant **EP4 receptor with IC₅₀ value of 35 nM and K_i** value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment ^[3].

Grapiprant-d4

Grapiprant-d₄ (CJ-023423-d₄) is the deuterium labeled Grapiprant (HY-16781). Grapiprant (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E₂ (PGE₂). Grapiprant displaces [ ³H]-PGE₂ (1 nM) binding to dog recombinant EP4 receptor with IC₅₀ value of 35 nM and K_i value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment ^[3].

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