16(R)-AFP 07 free acid
Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki=0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4. 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated.
For research use only. We do not sell to patients.
- CAS No.: 773825-80-2
- Formula: C22H30F2O5
- Molecular Weight:412.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 773825-80-2
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Molecular Weight 412.47
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Formula C22H30F2O5
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SMILES
O=C(O)CCC/C=C1C(F)(F)[C@@]([C@@H](/C=C/[C@H](O)[C@@H](C)CC#CCC)[C@H](O)C2)([H])[C@@]2([H])O/1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
16(R)-AFP 07 free acid Related Classifications
HY-129922 Related Classifications
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