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Results for "

Gene transfection

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Biochemical Assay Reagents (26) Caspase (1) DNA/RNA Synthesis (3) Endogenous Metabolite (2) Environmental Pollutants (1) Exosomes (1) Liposome (14) MDM-2/p53 (1) mRNA (4) Reference Standards (1) RET (18)
By Research Areas:	Cancer (22) Endocrinology (1) Infection (1) Metabolic Disease (2)
Click Chemistry:	DBCO (1)
Oligonucleotides:	Pegylated Lipids (2) mRNA (4) Cationic Lipids (10) Reporter Genes (4) Cap Analogs (2) Cholesterol (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Click Chemistry

Oligonucleotides

Targets Recommended: LAG-3 CGRP Receptor MALT1 Dan family RIG-I-like receptor (RLR) NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W127378

DOTAP methylsulfate Maximum Cited Publications 14 Publications Verification 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate	Liposome	Others
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .

HY-W250110

Polyethylenimine (branched) (30% in water) 5+ Cited Publications	Environmental Pollutants Biochemical Assay Reagents	Infection Others
Polyethylenimine (branched) (30% in water) is a organic macromolecule with high cationic-charge-density potential. Polyethylenimine (branched) (30% in water) can ensnare DNA as well as attach to cell membrane. Polyethylenimine (branched) (30% in water) also retains a substantial buffering capacity at virtually any pH. Polyethylenimine (branched) (30% in water) is widely used as transfection reagent .

HY-139200

DOTMA 1 Publications Verification	Liposome	Others
DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo .

HY-112760

18:0 mPEG2000 PE sodium 1 Publications Verification DSPE-mPEG2000 sodium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] sodium	Liposome	Others
18:0 mPEG2000 PE (DSPE-mPEG2000) sodium is a conjugate of phospholipid and polyethylene glycol, and it can serve as an important PEG lipid component in lipid nanoparticles (LNPs). 18:0 mPEG2000 PE sodium can be used in the research of gene transfection, drug carriers and drug delivery .

HY-P5423

GALA	Exosomes Liposome	Cancer
GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems .

HY-W590549

Dioleyldimethylammonium chloride DODAC	Liposome	Cancer
Dioleyldimethylammonium chloride (DODAC) is a positively charged lipid promoter with membrane-disrupting activity, which is often formulated into cationic liposomes with dioleoylphosphatidylethanolamine. Dioleyldimethylammonium chloride is used in gene transfection research; through electrostatic interactions, it effectively promotes the binding of programmable fusion vesicles to cells and induces membrane disruption. Dioleyldimethylammonium chloride is also applied in studies on L1210 leukemia and LS180 human colon cancer .

HY-150229

306-N16B	Liposome	Cancer
306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies .

HY-156135

NSC194598	MDM-2/p53 RET DNA/RNA Synthesis Apoptosis Caspase	Endocrinology Cancer
NSC194598 is a p53 DNA-binding inhibitor with an IC₅₀ value of 180 nM. NSC194598 inhibits p53 DNA binding and induction of target genesn when p53 is stabilized and activated by irradiation or chemotherapy. NSC194598 can interfere with transcriptional activation of mutated rearranged during transfection (RET) gene, induce apoptosis and G0/G1 phase arrest. NSC194598 can be used for the researches of acute radiation toxicity and medullary thyroid carcinoma .

HY-W010514

trans-Cyclohexane-1,2-diol	Endogenous Metabolite	Metabolic Disease
trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells .

HY-149037A

GL67 pentahydrochloride N4-Spermine cholesteryl carbamate pentahydrochloride	Liposome	Others
GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-144022

16:0 DAP	Liposome	Others
16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .

HY-145973A

3'OMe-m7GpppAmpG ammonium solution (100 mM) m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium solution (100 mM)	DNA/RNA Synthesis	Others
3'OMe-m7GpppAmpG (m7(3'OMeG)(5')ppp(5')(2'OMeA)pG) ammonium solution (100 mM) is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization .

HY-164035

DOPE-PEG2000-DBCO	Biochemical Assay Reagents	Others
DOPE-PEG2000-DBCO is a PEG lipid with a DOPE and a DBCO as functional groups. DOPE can be used as a helper lipid in gene transfection. PEG is used in drug delivery system. DBCO can be used for click chemistry .

HY-149037

GL67 N4-Spermine cholesteryl carbamate	Liposome	Others
GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-174795

mCherry mRNA	mRNA	Others
mCherry mRNA encodes the mCherry fluorescent protein, which is derived from Anaplasma marginale. mCherry can be used as a fluorescent tracer in transfection and transgenic experiments or as a reporter of gene expression.

HY-145973

3'OMe-m7GpppAmpG m7(3'OMeG)(5')ppp(5')(2'OMeA)pG	DNA/RNA Synthesis	Others
3'OMe-m7GpppAmpG is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG shows a significant translational efficiency. 3'OMe-m7GpppAmpG can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization .

HY-W800782

DC-6-14	Liposome	Others
DC-6-14 is a cationic lipid with gene transfection activity, which can be used for the synthesis of liposomes .

HY-17650

DMDHP (±)-Dimyristoyl-2,3-dimethylhydroxypropylamine	Liposome	Others
DMDHP ((±)-Dimyristoyl-2,3-dimethylhydroxypropylamine) is a cationic lipid with a polar head group containing a dihydroxy group. DMDHP exhibits superior transfection efficiency and lower toxicity at high DNA doses in mouse intrapulmonary transfection model. DMDHP is commonly used for gene delivery .

HY-150358

β-galactosidase mRNA Beta-galactosidase mRNA	mRNA	Others
β-galactosidase mRNA encodes β-galactosidase, a protein product of the bacterial LacZ gene. β-galactosidase catalyzes the conversion of β-galactosides into monosaccharides which could be used as a common marker to assess transfection efficiency.

HY-172558

MEL-A	Biochemical Assay Reagents	Others
MEL-A is a glycolipid biosurfactant. MEL-A can be produced from vegetable oils by Pseudozyma yeasts. MEL-A can improve the low-temperature fluidity of biodiesel and hydrocarbon fuels. MEL-A is composed of a mixture of MEL-A isoforms with variable lengths of the fatty acid chain. MEL-A can significantly increases gene transfection by cationic liposomes via membrane fusion .

HY-158705

SAINT-2	Liposome	Others
SAINT-2 is a cationic lipid with gene transfection activity and is a pyridyl lipid analog. Molecular membranes prepared by SAINT-2 can interact with plasmids to form lipid complexes. After the complex is taken up by cells, the plasmid dissociates from the lipid complex under the action of DOPE and the plasmid translocates across the endosome and/or nuclear membrane. Thus, SAINT-2 effectively transfers small oligonucleotides into cells .

HY-138913

2H-Cho-Arg TFA	Liposome	Cancer
2H-Cho-Arg (TFA) is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.

HY-158709

Cho-es-Lys	Biochemical Assay Reagents Liposome	Others
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .

HY-174964

8-Arm-PEG400-DSPE	Biochemical Assay Reagents	Others
8-Arm-PEG400-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957A

6-Arm-PEG600-DSPE	Biochemical Assay Reagents	Others
6-Arm-PEG600-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-W1123922D

4-Arm-PEG3400-DSPE	Biochemical Assay Reagents	Others
4-Arm-PEG3400-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG3400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957C

6-Arm-PEG2000-DSPE	Biochemical Assay Reagents	Others
6-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174501

β-galactosidase mRNA (5moU) Beta-galactosidase mRNA (5moU)	mRNA	Others
β-galactosidase mRNA (5moU) encodes β-galactosidase, a protein product of the bacterial LacZ gene. β-galactosidase catalyzes the conversion of β-galactosides into monosaccharides which could be used as a common marker to assess transfection efficiency. The incorporation of 5moU can reduce the immunogenicity of the resulting mRNA.

HY-E70776

RET S891A Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET S891A is a mutant of RET. RET S891A Recombinant Human Active Protein Kinase is a recombinant RET S891A protein that can be used to study RET S891A-related functions .

HY-E70778

RET V804L Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET V804L is a mutant of RET. RET V804L Recombinant Human Active Protein Kinase is a recombinant RET V804L protein that can be used to study RET V804L-related functions .

HY-E70777

RET V804E Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET V804E is a mutant of RET. RET V804E Recombinant Human Active Protein Kinase is a recombinant RET V804E protein that can be used to study RET V804E-related functions .

HY-E70859

RET L790F Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET L790F is a mutant of RET. RET L790F Recombinant Human Active Protein Kinase is a recombinant RET L790F protein that can be used to study RET L790F-related functions .

HY-E70771

RET L730I Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET L730I is a mutant of RET. RET L730I Recombinant Human Active Protein Kinase is a recombinant RET L730I protein that can be used to study RET L730I-related functions .

HY-E70779

RET V804M Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET V804M is a mutant of RET. RET V804M Recombinant Human Active Protein Kinase is a recombinant RET V804M protein that can be used to study RET V804M-related functions .

HY-E70767

RET G691S Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET G691S is a mutant of RET. RET G691S Recombinant Human Active Protein Kinase is a recombinant RET G691S protein that can be used to study RET G691S-related functions .

HY-E70768

RET G810C Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET G810C is a mutant of RET. RET G810C Recombinant Human Active Protein Kinase is a recombinant RET G810C protein that can be used to study RET G810C-related functions .

HY-E70773

RET M918T Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET M918T is a mutant of RET. RET M918T Recombinant Human Active Protein Kinase is a recombinant RET M918T protein that can be used to study RET M918T-related functions .

HY-E70775

RET R813Q Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET R813Q is a mutant of RET. RET R813Q Recombinant Human Active Protein Kinase is a recombinant RET R813Q protein that can be used to study RET R813Q-related functions .

HY-E70772

RET L730M Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET L730M is a mutant of RET. RET L730M Recombinant Human Active Protein Kinase is a recombinant RET L730M protein that can be used to study RET L730M-related functions .

HY-E70774

RET R749T Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET R749T is a mutant of RET. RET R749T Recombinant Human Active Protein Kinase is a recombinant RET R749T protein that can be used to study RET R749T-related functions .

HY-E70769

RET G810R Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET G810R is a mutant of RET. RET G810R Recombinant Human Active Protein Kinase is a recombinant RET G810R protein that can be used to study RET G810R-related functions .

HY-E70766

RET E762Q Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET E762Q is a mutant of RET. RET E762Q Recombinant Human Active Protein Kinase is a recombinant RET E762Q protein that can be used to study RET E762Q-related functions .

HY-E70780

RET Y791F Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET Y791F is a mutant of RET. RET Y791F Recombinant Human Active Protein Kinase is a recombinant RET Y791F protein that can be used to study RET Y791F-related functions .

HY-E70781

RET Y806H Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET Y806H is a mutant of RET. RET Y806H Recombinant Human Active Protein Kinase is a recombinant RET Y806H protein that can be used to study RET Y806H-related functions .

HY-E70770

RET G810S Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET G810S is a mutant of RET. RET G810S Recombinant Human Active Protein Kinase is a recombinant RET G810S protein that can be used to study RET G810S-related functions .

HY-W1123922H

4-Arm-PEG10000-DSPE	Biochemical Assay Reagents	Others
4-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964H

8-Arm-PEG10000-DSPE	Biochemical Assay Reagents	Others
8-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964E

8-Arm-PEG5000-DSPE	Biochemical Assay Reagents	Others
8-Arm-PEG5000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG5000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964C

8-Arm-PEG2000-DSPE	Biochemical Assay Reagents	Others
8-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-W1123922A

4-Arm-PEG600-DSPE	Biochemical Assay Reagents	Others
4-Arm-PEG600-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

Cat. No.	Product Name

HY-L214

Liposome Library

191 compounds

Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components.

MCE contains 191 liposome compounds, which is a good tool for lipidomic-related studies.

Cat. No.	Product Name	Type

HY-W127378

DOTAP methylsulfate

Maximum Cited Publications

14 Publications Verification

1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate

Biochemical Assay Reagents

DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .

HY-139200

DOTMA

1 Publications Verification

Biochemical Assay Reagents

DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo .

HY-112760

18:0 mPEG2000 PE sodium 1 Publications Verification DSPE-mPEG2000 sodium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] sodium	Biochemical Assay Reagents
18:0 mPEG2000 PE (DSPE-mPEG2000) sodium is a conjugate of phospholipid and polyethylene glycol, and it can serve as an important PEG lipid component in lipid nanoparticles (LNPs). 18:0 mPEG2000 PE sodium can be used in the research of gene transfection, drug carriers and drug delivery .

HY-150229

306-N16B

Biochemical Assay Reagents

306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies .

HY-149037A

GL67 pentahydrochloride N4-Spermine cholesteryl carbamate pentahydrochloride	Biochemical Assay Reagents
GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-144022

16:0 DAP	Biochemical Assay Reagents
16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .

HY-145973A

3'OMe-m7GpppAmpG ammonium solution (100 mM) m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium solution (100 mM)	Biochemical Assay Reagents
3'OMe-m7GpppAmpG (m7(3'OMeG)(5')ppp(5')(2'OMeA)pG) ammonium solution (100 mM) is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization .

HY-164035

DOPE-PEG2000-DBCO	Biochemical Assay Reagents
DOPE-PEG2000-DBCO is a PEG lipid with a DOPE and a DBCO as functional groups. DOPE can be used as a helper lipid in gene transfection. PEG is used in drug delivery system. DBCO can be used for click chemistry .

HY-149037

GL67 N4-Spermine cholesteryl carbamate	Biochemical Assay Reagents
GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-158709

Cho-es-Lys	Biochemical Assay Reagents
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .

HY-174964

8-Arm-PEG400-DSPE	Biochemical Assay Reagents
8-Arm-PEG400-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957A

6-Arm-PEG600-DSPE	Biochemical Assay Reagents
6-Arm-PEG600-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-W1123922D

4-Arm-PEG3400-DSPE	Biochemical Assay Reagents
4-Arm-PEG3400-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG3400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957C

6-Arm-PEG2000-DSPE	Biochemical Assay Reagents
6-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-W1123922H

4-Arm-PEG10000-DSPE	Biochemical Assay Reagents
4-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964H

8-Arm-PEG10000-DSPE	Biochemical Assay Reagents
8-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964E

8-Arm-PEG5000-DSPE	Biochemical Assay Reagents
8-Arm-PEG5000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG5000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964C

8-Arm-PEG2000-DSPE	Biochemical Assay Reagents
8-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-W1123922A

4-Arm-PEG600-DSPE	Biochemical Assay Reagents
4-Arm-PEG600-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957

6-Arm-PEG400-DSPE	Biochemical Assay Reagents
6-Arm-PEG400-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964A

8-Arm-PEG600-DSPE	Biochemical Assay Reagents
8-Arm-PEG600-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957H

6-Arm-PEG10000-DSPE	Biochemical Assay Reagents
6-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-W1123922C

4-Arm-PEG2000-DSPE	Biochemical Assay Reagents
4-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957B

6-Arm-PEG1000-DSPE	Biochemical Assay Reagents
6-Arm-PEG1000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG1000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964D

8-Arm-PEG3400-DSPE	Biochemical Assay Reagents
8-Arm-PEG3400-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG3400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-W1123922E

4-Arm-PEG5000-DSPE	Biochemical Assay Reagents
4-Arm-PEG5000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG5000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-W1123922B

4-Arm-PEG1000-DSPE	Biochemical Assay Reagents
4-Arm-PEG1000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG1000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957E

6-Arm-PEG5000-DSPE	Biochemical Assay Reagents
6-Arm-PEG5000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG5000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174964B

8-Arm-PEG1000-DSPE	Biochemical Assay Reagents
8-Arm-PEG1000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG1000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-W1123922

4-Arm-PEG400-DSPE	Biochemical Assay Reagents
4-Arm-PEG400-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

HY-174957D

6-Arm-PEG3400-DSPE	Biochemical Assay Reagents
6-Arm-PEG3400-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG3400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .

Cat. No.	Product Name	Target	Research Area

HY-P5423

GALA	Exosomes Liposome	Cancer
GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems .

HY-P10443

ppTG20	Peptides	Others
ppTG20 is an amphiphilic cell penetrating peptide (KALA) that can be used for gene transfection. ppTG20 can bind to DNA, destabilize membranes, and mediate DNA transfection .

HY-P11639

ppTG21	Biochemical Assay Reagents	Others
ppTG21 is an endosomolytic agent and inducer. ppTG21 can facilitate endosomal escape of Cas9-2lig-1NLS and Cas9-ASGPrL ribonucleoproteins (RNPs) to enable receptor-facilitated, cell-type specific gene editing in cancer cells without electroporation or transfection reagents. ppTG21 can be used for the research of gene editing .

Cat. No.	Product Name

HY-K2028

OptiLNP Gene Editing Kit (Immune Cells)
MCE OptiLNP Gene Editing Kit (Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient co-transfection of Cas9 mRNA and sgRNA during gene editing inimmune cells.

HY-K2027

OptiLNP Gene Editing Kit
MCE OptiLNP Gene Editing Kit is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient co-transfection of Cas9 mRNA and sgRNA during gene editing in common cells (adherent or suspension cells).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W010514

trans-Cyclohexane-1,2-diol	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells .

HY-W010514R

trans-Cyclohexane-1,2-diol (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
trans-Cyclohexane-1,2-diol (Standard) is the analytical standard of trans-Cyclohexane-1,2-diol (HY-W010514). This product is intended for research and analytical applications. trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells .

Cat. No.	Product Name		Classification

HY-164035

DOPE-PEG2000-DBCO		DBCO
DOPE-PEG2000-DBCO is a PEG lipid with a DOPE and a DBCO as functional groups. DOPE can be used as a helper lipid in gene transfection. PEG is used in drug delivery system. DBCO can be used for click chemistry .

Cat. No.	Product Name		Classification

HY-W127378

DOTAP methylsulfate Maximum Cited Publications 14 Publications Verification 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate		Cationic Lipids
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .

HY-139200

DOTMA 1 Publications Verification		Cationic Lipids
DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo .

HY-112760

18:0 mPEG2000 PE sodium 1 Publications Verification DSPE-mPEG2000 sodium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] sodium		Pegylated Lipids
18:0 mPEG2000 PE (DSPE-mPEG2000) sodium is a conjugate of phospholipid and polyethylene glycol, and it can serve as an important PEG lipid component in lipid nanoparticles (LNPs). 18:0 mPEG2000 PE sodium can be used in the research of gene transfection, drug carriers and drug delivery .

HY-W590549

Dioleyldimethylammonium chloride DODAC		Cationic Lipids
Dioleyldimethylammonium chloride (DODAC) is a positively charged lipid promoter with membrane-disrupting activity, which is often formulated into cationic liposomes with dioleoylphosphatidylethanolamine. Dioleyldimethylammonium chloride is used in gene transfection research; through electrostatic interactions, it effectively promotes the binding of programmable fusion vesicles to cells and induces membrane disruption. Dioleyldimethylammonium chloride is also applied in studies on L1210 leukemia and LS180 human colon cancer .

HY-150229

306-N16B		Cationic Lipids
306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies .

HY-149037A

GL67 pentahydrochloride N4-Spermine cholesteryl carbamate pentahydrochloride		Cationic Lipids
GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-144022

16:0 DAP		Cationic Lipids
16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .

HY-145973A

3'OMe-m7GpppAmpG ammonium solution (100 mM) m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium solution (100 mM)		Cap Analogs
3'OMe-m7GpppAmpG (m7(3'OMeG)(5')ppp(5')(2'OMeA)pG) ammonium solution (100 mM) is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization .

HY-164035

DOPE-PEG2000-DBCO		Pegylated Lipids
DOPE-PEG2000-DBCO is a PEG lipid with a DOPE and a DBCO as functional groups. DOPE can be used as a helper lipid in gene transfection. PEG is used in drug delivery system. DBCO can be used for click chemistry .

HY-149037

GL67 N4-Spermine cholesteryl carbamate		Cationic Lipids
GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .

HY-174795

mCherry mRNA		mRNA Reporter Genes
mCherry mRNA encodes the mCherry fluorescent protein, which is derived from Anaplasma marginale. mCherry can be used as a fluorescent tracer in transfection and transgenic experiments or as a reporter of gene expression.

HY-145973

3'OMe-m7GpppAmpG m7(3'OMeG)(5')ppp(5')(2'OMeA)pG		Cap Analogs
3'OMe-m7GpppAmpG is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG shows a significant translational efficiency. 3'OMe-m7GpppAmpG can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization .

HY-W800782

DC-6-14		Cationic Lipids
DC-6-14 is a cationic lipid with gene transfection activity, which can be used for the synthesis of liposomes .

HY-17650

DMDHP (±)-Dimyristoyl-2,3-dimethylhydroxypropylamine		Cationic Lipids
DMDHP ((±)-Dimyristoyl-2,3-dimethylhydroxypropylamine) is a cationic lipid with a polar head group containing a dihydroxy group. DMDHP exhibits superior transfection efficiency and lower toxicity at high DNA doses in mouse intrapulmonary transfection model. DMDHP is commonly used for gene delivery .

HY-150358

β-galactosidase mRNA Beta-galactosidase mRNA		mRNA Reporter Genes
β-galactosidase mRNA encodes β-galactosidase, a protein product of the bacterial LacZ gene. β-galactosidase catalyzes the conversion of β-galactosides into monosaccharides which could be used as a common marker to assess transfection efficiency.

HY-158705

SAINT-2		Cationic Lipids
SAINT-2 is a cationic lipid with gene transfection activity and is a pyridyl lipid analog. Molecular membranes prepared by SAINT-2 can interact with plasmids to form lipid complexes. After the complex is taken up by cells, the plasmid dissociates from the lipid complex under the action of DOPE and the plasmid translocates across the endosome and/or nuclear membrane. Thus, SAINT-2 effectively transfers small oligonucleotides into cells .

HY-138913

2H-Cho-Arg TFA		Cholesterol
2H-Cho-Arg (TFA) is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.

HY-158709

Cho-es-Lys		Cholesterol
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .

HY-174501

β-galactosidase mRNA (5moU) Beta-galactosidase mRNA (5moU)		mRNA Reporter Genes
β-galactosidase mRNA (5moU) encodes β-galactosidase, a protein product of the bacterial LacZ gene. β-galactosidase catalyzes the conversion of β-galactosides into monosaccharides which could be used as a common marker to assess transfection efficiency. The incorporation of 5moU can reduce the immunogenicity of the resulting mRNA.

HY-150359

β-galactosidase mRNA (N1-Methylpseudo-UTP) Beta-galactosidase mRNA (N1-Methylpseudo-UTP)		mRNA Reporter Genes
β-galactosidase mRNA (N1-Methylpseudo-UTP) encodes β-galactosidase, a protein product of the bacterial LacZ gene. β-galactosidase catalyzes the conversion of β-galactosides into monosaccharides which could be used as a common marker to assess transfection efficiency. The incorporation of N1-Methyl-pseudo-UTP can reduce the immunogenicity of the resulting mRNA.

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