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Results for "

KDM4 inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Apoptosis (3) Bacterial (3) CMV (1) Histone Demethylase (28) HSV (1) Isotope-Labeled Compounds (1) Reference Standards (4) β-catenin (3)
By Research Areas:	Cancer (26) Infection (3) Inflammation/Immunology (1)

Inhibitors & Agonists

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12304

IOX1 Maximum Cited Publications 14 Publications Verification	Histone Demethylase	Cancer
IOX1, a chemical probe, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC₅₀ values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively . IOX1 also inhibits ALKBH5 .

HY-104048

QC6352 10+ Cited Publications	Histone Demethylase	Cancer
QC6352 is an orally active *KDM4* inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits *KDM4* different isoforms with IC₅₀s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC₅₀ of 750 nM (KDM5B) .

HY-148807

Zavondemstat QC8222 free base; TACH 101 free base	Histone Demethylase Apoptosis	Cancer
Zavondemstat (QC8222 free base; TACH 101 free base) is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-100760

Toxoflavin 5+ Cited Publications Xanthothricin; Toxoflavine; PKF-118-310	β-catenin Bacterial Antibiotic Histone Demethylase	Infection Cancer
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of *KDM4A*, with antitumor and antibiotic activity .

HY-107573

KDM2/7-IN-1 1 Publications Verification	Histone Demethylase	Cancer
KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC₅₀ values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro .

HY-116761

GSK467 5 Publications Verification	Histone Demethylase	Cancer
GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a K_i of 10 nM and an IC₅₀ of 26 nM. GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members .

HY-12725

ML324 5+ Cited Publications	Histone Demethylase HSV CMV	Cancer
ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase *KDM4B, with an IC₅₀* of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression .

HY-132896

KDM4-IN-3	Histone Demethylase	Cancer
KDM4-IN-3 (Compound 15) is a *KDM4* inhibitor (IC₅₀ = 871 nM) that exhibits improved potency in biochemical assays. KDM4-IN-3 is cell-permeable and kills prostate cancer cells at low micro molar concentrations. KDM4-IN-3 inhibits growth of prostate cancer cell lines and increases the H3K9me3 abundance. KDM4-IN-3 can be studied in research for prostate cancer .

HY-101799

NCGC00244536 2 Publications Verification KDM4B inhibitor B3	Histone Demethylase	Cancer
NCGC00244536 is a potent *KDM4B* inhibitor with an IC₅₀ of 10 nM.

HY-110154

NSC636819	Histone Demethylase	Cancer
NSC636819 is a competitive and selective inhibitor of *KDM4A/KDM4B. KDM4A/KDM4B* are potential progression factors for prostate cancer. NSC636819 has the potential for the research of cancer diseases, especially prostate cancer .

HY-146148

KDM4C-IN-1 2 Publications Verification	Histone Demethylase	Cancer
KDM4C-IN-1 (Compound 4d) is a potent *KDM4C* inhibitor with an IC₅₀ of 8 nM. KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells with IC₅₀s of 0.8 µM and 1.1 µM, respectively .

HY-101928

KDM4D-IN-1 2 Publications Verification	Histone Demethylase	Cancer
KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC₅₀ value of 0.41±0.03 μM.

HY-112308

NCGC00247743 2 Publications Verification	Histone Demethylase	Cancer
NCGC00247743 is a histone lysine demethylase *KDM4* inhibitor.

HY-150619

KDM4-IN-4	Histone Demethylase	Cancer
KDM4-IN-4 (compound 47) is a potent histone lysine demethylase 4 (KDM4) inhibitor with a modest affinity binding to ~80 μM for KDM4A-Tudor domain. KDM4-IN-4 can inhibit H3K4Me3 binding to the Tudor domain in cells with an EC₅₀ value of 105 μM. KDM4-IN-4 can be used for researching anticancer .

HY-128343

KDM4-IN-2	Histone Demethylase	Cancer
KDM4-IN-2 (Compound 19a) is a potent and selective *KDM4/KDM5* dual inhibitor with K_is of 4 and 7 nM for KDM4A and KDM5B, respectively .

HY-120766

NCDM-32B	Histone Demethylase	Cancer
NCDM-32B is a potent and selective *KDM4* inhibitor, with IC₅₀ values of 3.0 μM for *KDM4A* and 1.0 μM for *KDM4C* in in vitro enzyme assays. NCDM-32B specifically increases global H3K9me3/me2 levels in basal breast cancer cells. NCDM-32B impairs the viability of *KDM4C*-amplified basal breast cancer cell lines (HCC1954 and Colo824). NCDM-32B can be used for the study of breast cancer .

HY-148807B

(S)-Zavondemstat (S)-QC8222 free base; (S)-TACH 101 free base	Histone Demethylase	Others
(S)-Zavondemstat is the S-enantiomer of Zavondemstat (HY-148807). Zavondemstat is an inhibitor of histone lysine demethylase 4D (KDM4D) with antineoplastic activity ^{[1] ^.}

HY-148807A

Zavondemstat L-lysine QC8222; TACH 101	Apoptosis Histone Demethylase	Cancer
Zavondemstat (QC8222; TACH 101) L-lysine is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat L-lysine induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat L-lysine suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat L-lysine can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-119730

Tripartin	Histone Demethylase	Cancer
Tripartin is an inhibitor of histone demethylase. Tripartin inhibits the histone H3 lysine 9 demethylase KDM4 in HeLa cells .

HY-148807C

Zavondemstat sodium QC8222 sodium; TACH 101 sodium	Apoptosis Histone Demethylase	Cancer
Zavondemstat (QC8222; TACH 101) sodium is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat sodium induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat sodium suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat sodium can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-126207

CBN209350	Histone Demethylase	Cancer
CBN209350 is a selective *KDM4* inhibitor with an IC₅₀ of 4 μM. CBN209350 exerts antiproliferative effects on prostate cancer cells. CBN209350 can be used for the research of prostate cancer .

HY-104048R

QC6352 (Standard)	Reference Standards Histone Demethylase	Cancer
QC6352 (Standard) is the analytical standard of QC6352 (HY-104048). This product is intended for research and analytical applications. QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC₅₀s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC₅₀ of 750 nM (KDM5B) .

HY-157408

KDM4D-IN-3	Histone Demethylase	Others
KDM4D-IN-3 (compound 1) is a small-molecule epigenetic inhibitor target at *KDM4D* with an IC₅₀ value of 4.8 μM .

HY-100760S

Toxoflavin-13C4 Xanthothricin-¹³C₄; Toxoflavine-¹³C₄; PKF-118-310-¹³C₄	Isotope-Labeled Compounds β-catenin Bacterial Antibiotic	Infection Cancer
Toxoflavin- ¹³C₄ is the ¹³C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity . Antibiotic properties.

HY-100760R

Toxoflavin (Standard) Xanthothricin (Standard); Toxoflavine (Standard); PKF-118-310 (Standard)	Reference Standards β-catenin Bacterial Antibiotic Histone Demethylase	Infection Cancer
Toxoflavin (Standard) is the analytical standard of Toxoflavin. This product is intended for research and analytical applications. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor and antibiotic activity[1][2].

HY-101799R

NCGC00244536 (Standard) KDM4B inhibitor B3 (Standard)	Reference Standards Histone Demethylase	Cancer
NCGC00244536 (Standard) (KDM4B Inhibitor B3 (Standard)) is the analytical standard of NCGC00244536 (HY-101799). This product is intended for research and analytical applications. NCGC00244536 is a potent KDM4B inhibitor with an IC₅₀ of 10 nM.

HY-101928R

KDM4D-IN-1 (Standard)	Reference Standards Histone Demethylase	Cancer
KDM4D-IN-1 (Standard) is the analytical standard of KDM4D-IN-1 (HY-101928). This product is intended for research and analytical applications. KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC₅₀ value of 0.41±0.03 μM.

HY-116796

KDM4C-IN-2	Histone Demethylase	Inflammation/Immunology Cancer
KDM4C-IN-2 is a histone lysine demethylase KDM4C (JMJD2C) inhibitor with an IC₅₀ of 147 μM and a K_i of 51 μM. KDM4C-IN-2 can be used for the research of cancer, such as prostate and breast cancer .

HY-183928

EPZ020809	Histone Demethylase	Others
EPZ020809 is a competitive *KDM4C* inhibitor with a K_i of 31 nM .

Toxoflavin-13C4
Toxoflavin- ¹³C₄ is the ¹³C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity . Antibiotic properties.

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