1. Stem Cell/Wnt
  2. β-catenin
  3. Toxoflavin

Toxoflavin (Synonyms: Xanthothricin; Toxoflavine; PKF-118-310)

Cat. No.: HY-100760
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Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity.

For research use only. We do not sell to patients.

Toxoflavin Chemical Structure

Toxoflavin Chemical Structure

CAS No. : 84-82-2

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Description

Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2].

IC50 & Target

TCF4/β-catenin[1], KDM4A[2]

In Vitro

Toxoflavin (Xanthothricin) exhibits dose-dependent cytotoxicity against the 3 hepatoma cell lines, and with IC50s of 0.66 μM, 0.36 μM and 0.98 μM for Hep40 cells, HepG2 cells and Huh7 cells respectively[1].

Molecular Weight

193.16

Formula

C₇H₇N₅O₂

CAS No.

84-82-2

SMILES

O=C(C1=NC=NN(C)C1=N2)N(C)C2=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Toxoflavin
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