1. Stem Cell/Wnt
  2. β-catenin
  3. Toxoflavin

Toxoflavin (Synonyms: Xanthothricin; Toxoflavine; PKF-118-310)

Cat. No.: HY-100760 Purity: 99.36%
Handling Instructions

Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity.

For research use only. We do not sell to patients.

Toxoflavin Chemical Structure

Toxoflavin Chemical Structure

CAS No. : 84-82-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
25 mg USD 390 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2].

IC50 & Target

TCF4/β-catenin[1], KDM4A[2]

In Vitro

Toxoflavin (Xanthothricin) exhibits dose-dependent cytotoxicity against the 3 hepatoma cell lines, and with IC50s of 0.66 μM, 0.36 μM and 0.98 μM for Hep40 cells, HepG2 cells and Huh7 cells respectively[1].

Molecular Weight

193.16

Formula

C₇H₇N₅O₂

CAS No.

84-82-2

SMILES

O=C(C1=NC=NN(C)C1=N2)N(C)C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (129.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1771 mL 25.8853 mL 51.7706 mL
5 mM 1.0354 mL 5.1771 mL 10.3541 mL
10 mM 0.5177 mL 2.5885 mL 5.1771 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ToxoflavinXanthothricinToxoflavinePKF-118-310β-cateninBeta cateninInhibitorinhibitorinhibit

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Toxoflavin
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HY-100760
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