1. Epigenetics
  2. Histone Demethylase
  3. KDM4-IN-2

KDM4-IN-2 

Cat. No.: HY-128343
Handling Instructions

KDM4-IN-2 (Compound 19a) is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.

For research use only. We do not sell to patients.

KDM4-IN-2 Chemical Structure

KDM4-IN-2 Chemical Structure

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Description

KDM4-IN-2 (Compound 19a) is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively[1].

IC50 & Target

Ki: 4 nM (KDM4A ), 7 nM (KDM5B)[1]
IC50: 100±41 nM (KDM4A), 43±21 nM (KDM4B), 38 nM (KDM5B), 123 nM (KDM5C), 4.50 μM (KDM2A), 5.78 μM (KDM3A), 90.22 μM (KDM6B)[1]

Molecular Weight

426.51

Formula

C₂₅H₂₆N₆O

SMILES

O=C1C2=CC=NC(N3C=C(CCN4CCC5(CCC6=C5C=CC=C6)CC4)C=N3)=C2N=CN1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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KDM4-IN-2
Cat. No.:
HY-128343
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