KDM4C-IN-1
Based on 2 publication(s) in Google Scholar
KDM4C-IN-1 is a histone lysine demethylase KDM4C inhibitor with an IC50 of 8 nM. KDM4C-IN-1 inhibits cancer cell proliferation. KDM4C-IN-1 can be used in the research of hepatocellular carcinoma and adenocarcinoma alveolar basal epithelial carcinoma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.13%
- CAS. Nr.: 52348-60-4
- Formel: C14H13N5O3
- Molecular Weight:299.28
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Macrocyclic Compound Library
HY-L041
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Anti-Cancer Metabolism Compound Library
HY-L083
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Methylation Compound Library
HY-L203
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Publications Citing Use of MedChemExpress (MCE) KDM4C-IN-1
More
Biologische Aktivität
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KDM4C 8 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| A549 | IC50 |
1.1 μM
Compound: 4d
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Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by Alamar blue assay
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[PMID: 31784197] |
| HepG2 | IC50 |
0.8 μM
Compound: 4d
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay
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[PMID: 31784197] |
KDM4C-IN-1 (Compound 4d) inhibits the proliferation of human hepatocellular carcinoma HepG2 cells after 24 h, with an IC50 value of 0.80 µM[1].
KDM4C-IN-1 (72 h) inhibits the proliferation of A549 human adenocarcinoma alveolar basal epithelial cells, with an IC50 of 1.1 µM[1].
KDM4C-IN-1 (10 µM; 60 min) exhibits high passive permeability across MDCKII-MDR1 cell monolayers (Papp (A2B) = 34.5 × 10-6 cm/sec) and is not a P-glycoprotein substrate[1].
KDM4C-IN-1 (1 µM; 0.3-60 min) exhibits extremely high metabolic stability in mouse liver microsomes, with a clearance rate of < 12.5 µL/min/mg protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 52348-60-4
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Appearance Solid
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Molecular Weight 299.28
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Formel C14H13N5O3
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Color Orange to red
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SMILES
O=C(C1=NC(C2=CC=C(OC)C=C2)=NN(C)C1=N3)N(C)C3=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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J Cardiovasc Transl Res
Targeting KDM4C Prevents Heart Failure after Acute Myocardial Infarction Via Activation of SOS2. [Abstract]2025 Jun;18(3):498-511. PMID: 39900886 -
Lösungsmittel & Löslichkeit
DMSO : ≥ 3 mg/mL (10.02 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3414 mL | 16.7068 mL | 33.4135 mL | 83.5338 mL |
| 5 mM | 0.6683 mL | 3.3414 mL | 6.6827 mL | 16.7068 mL | |
| 10 mM | 0.3341 mL | 1.6707 mL | 3.3414 mL | 8.3534 mL |
KDM4C-IN-1 Related Classifications
HY-146148 Related Classifications
Powered by Bioz
- KDM4C-IN-1
- 52348-60-4
- Histone Demethylase
- cancer cells
- adenocarcinomic human alveolar basal epithelial cancer
- MDCKII-MDR1 cells
- hepatocyte carcinoma
- KDM4C histone lysine demethylase
- HepG2 human hepatocyte carcinoma cell
- P-glycoprotein
- mouse liver microsomes
- A549 human adenocarcinomic alveolar basal epithelial cell
- Inhibitor
- inhibitor
- inhibit