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Cat. No.: HY-126207

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CBN209350

CBN209350 is a selective KDM4 inhibitor with an IC₅₀ of 4 μM. CBN209350 exerts antiproliferative effects on prostate cancer cells. CBN209350 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 726201-10-1
Formula: C₁₃H₁₂N₄O₃
Molecular Weight:272.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CBN209350 Chemical Structure

CAS No.: 726201-10-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Help & FAQs
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Biological Activity

Description

All Histone Demethylase Isoforms :

In Vitro

CBN209350 exerts inhibitory effects with comparable potency against all tested KDM4 family subtypes, and exhibits moderate selectivity for KDM4 over KDM2A (IC₅₀ 120 μM) and PHF8 (IC₅₀ 30 μM)^[1].
CBN209350 (48 h) exerts cytostatic effects on LnCaP prostate cancer cells^[1].
CBN209350 (100 μM; 48 h) reduces the level of H3K9me3 in PC-3 prostate cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human prostate cancer cell lines LnCaP, DU145, PC-3
Concentration:

Dose-response titration
Incubation Time:

48 h
Result:

Inhibited LnCaP cell viability with an IC₅₀ of 410 μM.
Did not reduce DU145 or PC-3 cell viability by 50% at concentrations up to 1000 μM (IC₅₀ >1000 μM for both cell lines).

ELISA Assay^[1]

Cell Line:

Human prostate cancer cell lines LnCaP, DU145, PC-3
Concentration:

100 μM
Incubation Time:

48 h
Result:

Did not alter global H3K9me3 levels relative to DMSO-treated control in LnCaP or DU145 cells.
Caused a significant decrease in global H3K9me3 levels relative to DMSO-treated control in PC-3 cells.

Chemical Information

CAS No. 726201-10-1
Molecular Weight 272.26
Formula C₁₃H₁₂N₄O₃
SMILES

O=C(OC)CC1=NN(C(=O)C1)C2=NC=3C=CC=CC3N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Carter DM, et al. Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells. SLAS Discov. 2017;22(7):801-812. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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CBN209350

All Histone Demethylase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CBN209350 Related Classifications

HY-126207 Related Classifications