2. Epigenetics
  3. Histone Demethylase
  4. CBN209350

CBN209350 is a selective KDM4 inhibitor with an IC50 of 4 μM. CBN209350 exerts antiproliferative effects on prostate cancer cells. CBN209350 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

CBN209350

CBN209350 Chemical Structure

CAS No. : 726201-10-1

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CBN209350 Related Antibodies

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Description

CBN209350 is a selective KDM4 inhibitor with an IC50 of 4 μM. CBN209350 exerts antiproliferative effects on prostate cancer cells. CBN209350 can be used for the research of prostate cancer[1].

In Vitro

CBN209350 exerts inhibitory effects with comparable potency against all tested KDM4 family subtypes, and exhibits moderate selectivity for KDM4 over KDM2A (IC50 120 μM) and PHF8 (IC50 30 μM)[1].
CBN209350 (48 h) exerts cytostatic effects on LnCaP prostate cancer cells[1].
CBN209350 (100 μM; 48 h) reduces the level of H3K9me3 in PC-3 prostate cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CBN209350 Related Antibodies

Cell Viability Assay[1]

Cell Line: Human prostate cancer cell lines LnCaP, DU145, PC-3
Concentration: Dose-response titration
Incubation Time: 48 h
Result: Inhibited LnCaP cell viability with an IC50 of 410 μM.
Did not reduce DU145 or PC-3 cell viability by 50% at concentrations up to 1000 μM (IC50 >1000 μM for both cell lines).

ELISA Assay[1]

Cell Line: Human prostate cancer cell lines LnCaP, DU145, PC-3
Concentration: 100 μM
Incubation Time: 48 h
Result: Did not alter global H3K9me3 levels relative to DMSO-treated control in LnCaP or DU145 cells.
Caused a significant decrease in global H3K9me3 levels relative to DMSO-treated control in PC-3 cells.
Molecular Weight

272.26

Formula

C13H12N4O3
CAS No.
SMILES

O=C(OC)CC1=NN(C(=O)C1)C2=NC=3C=CC=CC3N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CBN209350 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBN209350726201-10-1CBN 209350CBN-209350Histone DemethylaseLnCaPDU145prostate cancer cellsKDM4 inhibitorJmjd-KDM superfamilyPC-3KDM4EFDHhistone demethylationH3K9me3Inhibitorinhibitorinhibit

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