1. Epigenetics
  2. Histone Demethylase
  3. NCGC00247743

NCGC00247743 

Cat. No.: HY-112308 Purity: 99.35%
Handling Instructions

NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.

For research use only. We do not sell to patients.

NCGC00247743 Chemical Structure

NCGC00247743 Chemical Structure

CAS No. : 1435192-04-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.

IC50 & Target

KDM4[1]

In Vitro

Based on structure-activity relationship studies, a series of chemical compounds are derived from 8-hydroxyquinoline (8HQ) and shown to be active inhibitors of KDM4E and KDM4A. The effect of these compounds is tested on the growth of LNCaP cells and NCGC00247751 (A1), NCGC00244536 (B3), and NCGC00247743 (I9) are selected. These inhibitors inhibit LNCaP cell growth with IC50s in the μM range. These compounds also inhibit the enzymatic activity of other KDM4 isoforms although, interestingly, the potency and efficacy of B3 and A1 for KDM4A, 4C, and 4D are lower compared to that of NCGC00247743 (I9), suggesting a potential selectivity of the inhibitors for different isoforms of KDM4[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (159.64 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5542 mL 12.7711 mL 25.5421 mL
5 mM 0.5108 mL 2.5542 mL 5.1084 mL
10 mM 0.2554 mL 1.2771 mL 2.5542 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

391.51

Formula

C₂₄H₂₉N₃O₂

CAS No.

1435192-04-3

SMILES

OC1=C(N=CC=C2)C2=CC(C3=CC(C(NCCCCCCN(C)C)=O)=CC=C3)=C1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
NCGC00247743
Cat. No.:
HY-112308
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NCGC00247743

Cat. No.: HY-112308