1. Epigenetics
  2. Histone Demethylase
  3. NCGC00247743

NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.

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NCGC00247743 Chemical Structure

NCGC00247743 Chemical Structure

CAS No. : 1435192-04-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 605 In-stock
Solution
10 mM * 1 mL in DMSO USD 605 In-stock
Solid
5 mg USD 550 In-stock
10 mg USD 850 In-stock
25 mg USD 1600 In-stock
50 mg USD 2550 In-stock
100 mg USD 3800 In-stock
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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE NCGC00247743

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Description

NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.

IC50 & Target

KDM4[1]

In Vitro

Based on structure-activity relationship studies, a series of chemical compounds are derived from 8-hydroxyquinoline (8HQ) and shown to be active inhibitors of KDM4E and KDM4A. The effect of these compounds is tested on the growth of LNCaP cells and NCGC00247751 (A1), NCGC00244536 (B3), and NCGC00247743 (I9) are selected. These inhibitors inhibit LNCaP cell growth with IC50s in the μM range. These compounds also inhibit the enzymatic activity of other KDM4 isoforms although, interestingly, the potency and efficacy of B3 and A1 for KDM4A, 4C, and 4D are lower compared to that of NCGC00247743 (I9), suggesting a potential selectivity of the inhibitors for different isoforms of KDM4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

391.51

Formula

C24H29N3O2

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=C(N=CC=C2)C2=CC(C3=CC(C(NCCCCCCN(C)C)=O)=CC=C3)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (159.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5542 mL 12.7711 mL 25.5421 mL
5 mM 0.5108 mL 2.5542 mL 5.1084 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5542 mL 12.7711 mL 25.5421 mL 63.8553 mL
5 mM 0.5108 mL 2.5542 mL 5.1084 mL 12.7711 mL
10 mM 0.2554 mL 1.2771 mL 2.5542 mL 6.3855 mL
15 mM 0.1703 mL 0.8514 mL 1.7028 mL 4.2570 mL
20 mM 0.1277 mL 0.6386 mL 1.2771 mL 3.1928 mL
25 mM 0.1022 mL 0.5108 mL 1.0217 mL 2.5542 mL
30 mM 0.0851 mL 0.4257 mL 0.8514 mL 2.1285 mL
40 mM 0.0639 mL 0.3193 mL 0.6386 mL 1.5964 mL
50 mM 0.0511 mL 0.2554 mL 0.5108 mL 1.2771 mL
60 mM 0.0426 mL 0.2129 mL 0.4257 mL 1.0643 mL
80 mM 0.0319 mL 0.1596 mL 0.3193 mL 0.7982 mL
100 mM 0.0255 mL 0.1277 mL 0.2554 mL 0.6386 mL
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NCGC00247743 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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