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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

NCI-H187 cells

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

9

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W779529
    Cerberin

    2'-Acetylneriifolin

    		 Na+/K+ ATPase Cancer
    Cerberin is a cardiac glycoside that has been found in C. odollam and has cytotoxic and cardiac modulatory activities. It is cytotoxic to KB and NCI H187 cancer cells (IC50s=1.92 and 1.24 μg/mL).1 Cerberin inhibits Na+/K+-ATPase, increasing intracellular sodium levels and action potential duration in cardiac cells.
    Cerberin
  • HY-145379
    Miaosporone A

    		Parasite Endogenous Metabolite Infection
    Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC50 values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .
    Miaosporone A
  • HY-N15652
    Versimide

    		Biochemical Assay Reagents Cancer
    Versimide (Compound 15) can be isolated from the insect pathogenic fungus Gibellula sp. BCC36964. Versimide exhibits cytotoxicity in cell lines including MCF-7, KB, NCI-H187, and Vero with IC50s of 3.59, 4.83, 1.89, and 3.49 μg/mL, respectively, demonstrating its anticancer activity .
    Versimide
  • HY-N12232
    Carbazomycin D

    		Parasite Bacterial Infection Cancer
    Carbazomycin D exhibits antituberculosis and antimalarial activities, that inhibits Plasmodium falciparum with an IC50 > 10 μg/mL, inhibits Mycobacterium tuberculosis with MIC of 25 μg/mL. Carbazomycin D exhibits cytotoxicity in cell MCF-7, KB, NCI-H187 and Vero, with IC50s of 21.3, 33.2, 12.9, and 34.3 μg/mL, respectively .
    Carbazomycin D
  • HY-N8470
    Steffimycin B

    NSC 204855; U 40615

    		 Bacterial Infection
    Steffimycin B is an anthracycline bacterial metabolite originally isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine.2 Steffimycin B is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC50s=3.5, 6.75, 3.28, and 10.5 μM, respectively). It is active against M. tuberculosis (MIC=5.2 nM), B. cereus (MIC=1.56 μg/mL), and P. falciparum (IC50=2.19 μM).
    Steffimycin B
  • HY-N12230
    Penicolinate B

    		Bacterial Parasite Fungal Infection Cancer
    Penicolinate B is a picolinic acid derivative that can be isolated from Penicillium sp. Penicolinate B exhibits antimalarial activity (IC50: 1.40 μg/mL), antitubercular activity (MIC: 25.0 μg/mL), activity against Bacillus cereus (IC50: 25.0 μg/mL), and activity against Candida albicans (IC50: 1.45 μg/mL). Penicolinate B also has certain cytotoxicity against cancer cells such as MCF-7, KB, and NCI-H187. Penicolinate B can be used in research on malaria, tuberculosis, bacterial/fungal infections and tumors .
    Penicolinate B
  • HY-N9475
    Betulonaldehyde

    		Parasite Infection Inflammation/Immunology Cancer
    Betulonaldehyde is a pentacyclic triterpenoid that can be isolated from Diospyros filipendula. Betulonaldehyde has antiplasmodial activity (IC50: 3.36 µg/mL). Betulonaldehyde has cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s: 19.23 and 17.09 µg/mL, respectively). Betulonaldehyde inhibits Phorbol 12-myristate 13-acetate (HY-18739) induced inflammation in mice .
    Betulonaldehyde
  • HY-N7302
    Anthracophyllone

    		Others Cancer
    Anthracophyllone is an aristolane sesquiterpene that can be isolated from the mushroom Anthracophyllum. Anthracophyllone has cytotoxicity against MCF-7, KB, NCI-H187, Vero cells (IC50: 32.97, 18.02, 15.17, 18.06 μM) .
    Anthracophyllone
  • HY-178724
    Mollicellin K

    		Fungal Bacterial Parasite Infection Cancer
    Mollicellin K is a depsidone that can be isolated from the fungus Chaetomium brasiliense. Mollicellin K exhibits antimicrobial activity against Myobacterium tuberculosis, antimalarial activity (IC50 = 1.2 μM) against Plasmodium falciparum as well as antifungal property (IC50 = 1.2 μM) against Candida albicans. Mollicellin K is cytotoxic against KB (IC50 = 1.9 μM), BC1 (IC50 = 6.8 μM), NCI-H187 (IC50 = 0.35 μM), and five cholangiocarcinoma cell lines. Mollicellin K also has an MIC of 12.5 μM for tuberculosis .
    Mollicellin K
  • HY-N19792
    6-(3'-Methyl-1',3'-butadienyl)-5,7-dimethoxycoumarin

    		Drug Derivative Cancer
    6-(3'-Methyl-1',3'-butadienyl)-5,7-dimethoxycoumarin is a cytotoxic coumarin compound that can be isolated from the stem bark of Toddalia asiatica. 6-(3'-Methyl-1',3'-butadienyl)-5,7-dimethoxycoumarin can be used for the research of small cell lung cancer .
    6-(3'-Methyl-1',3'-butadienyl)-5,7-dimethoxycoumarin
  • HY-N15054
    17-O-Demethylgeldanamycin

    		Drug Derivative Cancer
    17-O-Demethylgeldanamycin is a secondary metabolite that can be isolated from Streptomyces. 17-O-Demethylgeldanamycin exhibits cytotoxicity against a variety of tumor cells and has anti-tumor activity .
    17-O-Demethylgeldanamycin
  • HY-N16806
    Yunnancoronarin B

    		Drug Derivative Others
    Yunnancoronarin B is a natural diterpene.
    Yunnancoronarin B

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