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Isoforms Recommended: Serine β-lactamase (SBL)
Results for "

OXA-48

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Peptides

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-109124
    Taniborbactam
    Maximum Cited Publications
    17 Publications Verification

    VNRX-5133

    		 Beta-lactamase Bacterial Infection
    Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria .
    Taniborbactam
  • HY-109124A
    Taniborbactam hydrochloride
    Maximum Cited Publications
    17 Publications Verification

    VNRX-5133 hydrochloride

    		 Beta-lactamase Bacterial Infection
    Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria .
    Taniborbactam hydrochloride
  • HY-N2736
    3′,4′,7-Trihydroxyflavone
    1 Publications Verification

    		 Beta-lactamase COX Interleukin Related Bacterial JNK ERK p38 MAPK STAT Apoptosis NO Synthase Nuclear Factor of activated T Cells (NFAT) Lactate Dehydrogenase Reactive Oxygen Species (ROS) SOD Akt Caspase Bcl-2 Family Infection Neurological Disease Inflammation/Immunology
    3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC50 = 1.89 μM) and COX-1 (IC50 = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H2O2-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice .
    3′,4′,7-Trihydroxyflavone
  • HY-139745
    FPI-1523 sodium

    		Beta-lactamase Bacterial Infection
    FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity .
    FPI-1523 sodium
  • HY-139744
    FPI-1465

    		Beta-lactamase Penicillin-binding protein (PBP) Bacterial Infection
    FPI-1465 acts a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs).FPI-1465 inhibits PBP2 (IC50=1.0 µg/mL). FPI-1465 exhibits activity against β-lactamase CTX-M-15 and OXA-48 with Kds of 0.011 and 5.3 µM, respectively .
    FPI-1465
  • HY-W151758
    2'-Hydroxybiphenyl-3-carboxylic acid

    		Beta-lactamase Others
    2'-Hydroxybiphenyl-3-carboxylic acid is a β-lactamase oxa-48 inhibitor (IC50 = 50 µM; Kd = 1750 µM) .
    2'-Hydroxybiphenyl-3-carboxylic acid
  • HY-178976
    YL6113

    		Beta-lactamase Infection
    YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC50 values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC50 values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection .
    YL6113
  • HY-122699
    LN-1-255 sodium

    		Beta-lactamase Bacterial Infection
    LN-1-255 sodium is a β-lactamase inhibitor. LN-1-255 sodium has broad-spectrum inhibitory effect on type D carbapenemases (CHDLs) with an IC50 for OXA-48 of 3 nM, and it also has strong activity against OXA-23, OXA-24/40, etc. LN-1-255 sodium combined with carbapenem antibiotics has a synergistic effect. LN-1-255 sodium can be used to study the bacterial resistance crisis caused by CHDLs .
    LN-1-255 sodium
  • HY-139745A
    FPI-1523

    		Beta-lactamase Bacterial Infection
    FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity .
    FPI-1523
  • HY-161094
    Metallo-β-lactamase-IN-12

    		Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and serine β-lactamases (SβLs (OXA-48, KPC-2)), with IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity .
    Metallo-β-lactamase-IN-12
  • HY-P11720
    M104 peptide

    		Beta-lactamase Bacterial Infection
    M104 peptide is an OXA-48 carbapenemase inhibitor and antibiotic potentiator. M104 peptide effectively blocks the binding and active site cavity of OXA-48 . M104 peptide restores Meropenem (HY-13678)’s antibacterial activity against OXA-48-producing Klebsiella pneumoniae. M104 peptide can be used for the research of Carbapenem-resistant Klebsiella pneumoniae infection .
    M104 peptide
  • HY-182058
    ATM potentiator-1

    		Beta-lactamase Infection
    ATM potentiator-1 (compound 9) is a β-lactamase inhibitor and efflux pump inhibitor, with an IC50 of 1.6 μM against NDM-1, IC50 values of 12.5 μM and 5.4 μM against OXA-10, an IC50 of 5.0 μM against VIM-2, an IC50 of 26.7 μM against KPC-2, and an IC50 of 3.4 μM against OXA-48. ATM potentiator-1 inhibits the efflux pump activity of *Pseudomonas aeruginosa* and exerts a synergistic inhibitory effect when combined with CCCP. ATM potentiators-1 can be used for the research of carbapenem-resistant *Pseudomonas aeruginosa* (CRPA) infections .
    ATM potentiator-1

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