FPI-1523 sodium
Based on 1 Customer Validation
FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 1452459-52-7
- Formula: C9H13N4NaO7S
- Molecular Weight:344.27
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Beta-lactamase Isoforms
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Biological Activity
β-lactamase[1]
FPI-1523 sodium inhibits K12 E. coli K12 and PBP2, with MIC and IC50 of 4 μg/mL and 0.4 μg/mL, respectively[1].
FPI-1523 sodium inhibit E. coli BW25113 pGDP-2 transformants either with an empty vector or expressing different β-lactamases, with low MICs (1-2 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1452459-52-7
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Appearance Solid
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Molecular Weight 344.27
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Formula C9H13N4NaO7S
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Color White to off-white
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SMILES
CC(NNC([C@H]1[N@@]2C(N([C@H](CC1)C2)OS(=O)(O[Na])=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 125 mg/mL (363.09 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.9047 mL | 14.5235 mL | 29.0470 mL | 72.6174 mL |
| 5 mM | 0.5809 mL | 2.9047 mL | 5.8094 mL | 14.5235 mL | |
| 10 mM | 0.2905 mL | 1.4523 mL | 2.9047 mL | 7.2617 mL | |
| 15 mM | 0.1936 mL | 0.9682 mL | 1.9365 mL | 4.8412 mL | |
| 20 mM | 0.1452 mL | 0.7262 mL | 1.4523 mL | 3.6309 mL | |
| 25 mM | 0.1162 mL | 0.5809 mL | 1.1619 mL | 2.9047 mL | |
| 30 mM | 0.0968 mL | 0.4841 mL | 0.9682 mL | 2.4206 mL | |
| 40 mM | 0.0726 mL | 0.3631 mL | 0.7262 mL | 1.8154 mL | |
| 50 mM | 0.0581 mL | 0.2905 mL | 0.5809 mL | 1.4523 mL | |
| 60 mM | 0.0484 mL | 0.2421 mL | 0.4841 mL | 1.2103 mL | |
| 80 mM | 0.0363 mL | 0.1815 mL | 0.3631 mL | 0.9077 mL | |
| 100 mM | 0.0290 mL | 0.1452 mL | 0.2905 mL | 0.7262 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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