2. Anti-infection
  3. Beta-lactamase Bacterial
  4. FPI-1523 sodium

FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity.

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FPI-1523 sodium Chemical Structure

FPI-1523 sodium Chemical Structure

CAS No. : 1452459-52-7

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FPI-1523 sodium Related Antibodies

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Description

FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity[1].

IC50 & Target

β-lactamase[1]
In Vitro

FPI-1523 sodium inhibits K12 E. coli K12 and PBP2, with MIC and IC50 of 4 μg/mL and 0.4 μg/mL, respectively[1].
FPI-1523 sodium inhibit E. coli BW25113 pGDP-2 transformants either with an empty vector or expressing different β-lactamases, with low MICs (1-2 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FPI-1523 sodium Related Antibodies
Molecular Weight

344.28

Formula

C9H13N4NaO7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(NNC([C@H]1[N@@]2C(N([C@H](CC1)C2)OS(=O)(O[Na])=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (363.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9046 mL 14.5231 mL 29.0461 mL
5 mM 0.5809 mL 2.9046 mL 5.8092 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9046 mL 14.5231 mL 29.0461 mL 72.6153 mL
5 mM 0.5809 mL 2.9046 mL 5.8092 mL 14.5231 mL
10 mM 0.2905 mL 1.4523 mL 2.9046 mL 7.2615 mL
15 mM 0.1936 mL 0.9682 mL 1.9364 mL 4.8410 mL
20 mM 0.1452 mL 0.7262 mL 1.4523 mL 3.6308 mL
25 mM 0.1162 mL 0.5809 mL 1.1618 mL 2.9046 mL
30 mM 0.0968 mL 0.4841 mL 0.9682 mL 2.4205 mL
40 mM 0.0726 mL 0.3631 mL 0.7262 mL 1.8154 mL
50 mM 0.0581 mL 0.2905 mL 0.5809 mL 1.4523 mL
60 mM 0.0484 mL 0.2421 mL 0.4841 mL 1.2103 mL
80 mM 0.0363 mL 0.1815 mL 0.3631 mL 0.9077 mL
100 mM 0.0290 mL 0.1452 mL 0.2905 mL 0.7262 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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FPI-1523 sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FPI-15231452459-52-7FPI1523FPI 1523Beta-lactamaseBacterialβ-lactamaseAvibactamCTX-M-15OXA-48PBP2antimicrobialInhibitorinhibitorinhibit

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