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Cat. No.: HY-122699

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LN-1-255 sodium

LN-1-255 sodium is a β-lactamase inhibitor. LN-1-255 sodium has broad-spectrum inhibitory effect on type D carbapenemases (CHDLs) with an IC₅₀ for OXA-48 of 3 nM, and it also has strong activity against OXA-23, OXA-24/40, etc. LN-1-255 sodium combined with carbapenem antibiotics has a synergistic effect. LN-1-255 sodium can be used to study the bacterial resistance crisis caused by CHDLs.

For research use only. We do not sell to patients.

CAS No.: 247115-03-3
Formula: C₂₂H₁₉N₂NaO₉S
Molecular Weight:510.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

LN-1-255 sodium Chemical Structure

CAS No.: 247115-03-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Beta-lactamase Isoforms :

Chemical Information

CAS No. 247115-03-3
Molecular Weight 510.45
Formula C₂₂H₁₉N₂NaO₉S
SMILES

O=C([C@@H]([C@](C)(COC(CC1=CC=C(O)C(O)=C1)=O)S([C@]2([H])/C3=C\C4=NC=CC=C4)(=O)=O)N2C3=O)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vallejo JA, et al. LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48. J Antimicrob Chemother. 2016 Aug;71(8):2171-80. [Content Brief]

[2]. Vázquez-Ucha JC, et al. Activity of the β-Lactamase Inhibitor LN-1-255 against Carbapenem-Hydrolyzing Class D β-Lactamases from Acinetobacter baumannii. Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01172-17. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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