247115-03-3
Chemical Structure
LN-1-255 sodium
- CAS No.: 247115-03-3
- Formula:C22H19N2NaO9S
- Molecular Weight:510.45
IUPAC Name: sodium (2S,3R,5R,Z)-3-((2-(3,4-dihydroxyphenyl)acetoxy)methyl)-3-methyl-7-oxo-6-(pyridin-2-ylmethylene)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
InChIKey: OISRDGHGSAOFKW-OIGABSMWSA-M
SMILES: O=C([C@@H]([C@](C)(COC(CC1=CC=C(O)C(O)=C1)=O)S([C@]2([H])/C3=C\C4=NC=CC=C4)(=O)=O)N2C3=O)O[Na]
Biological Activity: LN-1-255 sodium is a β-lactamase inhibitor. LN-1-255 sodium has broad-spectrum inhibitory effect on type D carbapenemases (CHDLs) with an IC50 for OXA-48 of 3 nM, and it also has strong activity against OXA-23, OXA-24/40, etc. LN-1-255 sodium combined with carbapenem antibiotics has a synergistic effect. LN-1-255 sodium can be used to study the bacterial resistance crisis caused by CHDLs[1][2].
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LN-1-255 sodium | LN-1-255 sodium is a β-lactamase inhibitor. LN-1-255 sodium has broad-spectrum inhibitory effect on type D carbapenemases (CHDLs) with an IC50 for OXA-48 of 3 nM, and it also has strong activity against OXA-23, OXA-24/40, etc. LN-1-255 sodium combined with carbapenem antibiotics has a synergistic effect. LN-1-255 sodium can be used to study the bacterial resistance crisis caused by CHDLs. | |||||||||||||||||||||
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References
- [1]. Vallejo JA, et al. LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48. J Antimicrob Chemother. 2016 Aug;71(8):2171-80. [Content Brief]
- [2]. Vázquez-Ucha JC, et al. Activity of the β-Lactamase Inhibitor LN-1-255 against Carbapenem-Hydrolyzing Class D β-Lactamases from Acinetobacter baumannii. Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01172-17. [Content Brief]
