RAM

By Targets:	AMPK (1) Apoptosis (1) Bacterial (1) Cholinesterase (ChE) (1) COX (2) Drug Derivative (1) Free Fatty Acid Receptor (1) Huntingtin (1) IKK (2) Lipoxygenase (1) NO Synthase (2) PGC-1α (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Sirtuin (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Endocrinology (2) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (2) Antisense Oligonucleotides (2) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W010066

3,4-Dihydroxyphenylglycol	NO Synthase COX IKK	Inflammation/Immunology Endocrinology
3,4-Dihydroxyphenylglycol is a phenolic compound and antioxidant. 3,4-Dihydroxyphenylglycol can be extracted from olive oil. 3,4-Dihydroxyphenylglycol downregulates the expression of proinflammatory enzymes (iNOS, COX-2) and prevents the degradation of IκBα. 3,4-Dihydroxyphenylglycol has antioxidant properties. 3,4-Dihydroxyphenylglycol has shown positive effects on frozen-thawed ram sperm. 3,4-Dihydroxyphenylglycol can be used in the study of inflammatory-related diseases (such as ulcerative colitis) and reproductive health (sperm cryopreservation) .

HY-132593

Rovanersen WVE-120101	Huntingtin	Neurological Disease
Rovanersen (WVE-120101) is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of HTT gene, thereby preventing the production of faulty Huntingtin protein. Rovanersen can be used for huntington’s disease research .

HY-RS11537

RAB27A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAB27A Human Pre-designed siRNA Set A contains three designed siRNAs for RAB27A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAB27A Human Pre-designed siRNA Set A RAB27A Human Pre-designed siRNA Set A

HY-148412

Monarsen EN101; ODN 7040; BL 7040	Cholinesterase (ChE)	Others
Monarsen (EN101) is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).

HY-176855

RAM1147	Bacterial	Metabolic Disease Cancer
RAM1147 is a farnesyl pyrophosphate synthase (FPPS) inhibitor. RAM1147 disrupts protein isoprenylation, inhibiting tumor cell proliferation. RAM1147 is promising for research of cancers (e.g., myeloma, breast cancer) and bone metabolism disorders (e.g., osteoporosis) .

HY-136855

MitoPBN	Sirtuin AMPK PGC-1α Apoptosis Reactive Oxygen Species (ROS)	Metabolic Disease
MitoPBN is a AMPK/SIRT3/PGC-1α axis modulator, reactive oxygen species scavenger and mitochondrial function enhancer. MitoPBN increases the phosphorylation level of AMPK, restores SIRT3 expression and reverses the down-regulation of PGC-1α, thereby promoting mitochondrial biogenesis. MitoPBN regulates glucose metabolism, reduces blood glucose by inhibiting hepatic gluconeogenesis and increasing hepatic glucose uptake, while scavenging mitochondrial superoxide anion/hydrogen peroxide, maintaining membrane potential and increasing ATP production. MitoPBN also reduces cell apoptosis, improves sperm motility, survival rate and membrane integrity, but may induce reductive stress in cryopreserved sperm at high concentrations. MitoPBN is widely applicable to research related to diabetes and type 2 diabetes .

HY-RS11637

RAMAC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAMAC Human Pre-designed siRNA Set A contains three designed siRNAs for RAMAC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAMAC Human Pre-designed siRNA Set A RAMAC Human Pre-designed siRNA Set A

HY-W010066R

3,4-Dihydroxyphenylglycol (Standard)	Reference Standards NO Synthase COX IKK	Inflammation/Immunology Endocrinology
3,4-Dihydroxyphenylglycol (Standard) is the analytical standard of 3,4-Dihydroxyphenylglycol (HY-W010066). This product is intended for research and analytical applications. 3,4-Dihydroxyphenylglycol is a phenolic compound and antioxidant. 3,4-Dihydroxyphenylglycol can be extracted from olive oil. 3,4-Dihydroxyphenylglycol downregulates the expression of proinflammatory enzymes (iNOS, COX-2) and prevents the degradation of IκBα. 3,4-Dihydroxyphenylglycol has antioxidant properties. 3,4-Dihydroxyphenylglycol has shown positive effects on frozen-thawed ram sperm. 3,4-Dihydroxyphenylglycol can be used in the study of inflammatory-related diseases (such as ulcerative colitis) and reproductive health (sperm cryopreservation) .

HY-118156

L-699333	Others	Others
L-699333 is a 5-lipoxygenase (5-LO) inhibitor belonging to the thieno[2,3,4-cd]indole class. This compound has a 2-ethoxybutyric acid side chain and is a potent inhibitor of the biosynthesis of 5-HPETE and LTB4 produced from human 5-LO, with ICm values of 22 nM, 7 nM, and 3.8 pM for human neutrophils and whole blood, respectively. L-699333 has shown anti-inflammatory and antiasthmatic effects in a variety of animal models, including rat pleurisy models, antigen-induced wheezing models, and awake macaque and sheep asthma models. Its inhibition of 5-LO is highly selective, with higher ICm values or stronger competitive inhibition in FLAP binding assays compared to inhibition of human 15-LO, porcine 12-LO, and ram epididymal cyclooxygenase. The racemic enantiomer 14g of L-699333 is the most potent enantiomer to date, with inhibitory effects similar to those of the known MK-0591, which has been shown in clinical trials to inhibit the biochemical effects of LTB4 biosynthesis in vitro and LTE4 excretion in urine.

HY-13467A

(R)-AM-1638	Free Fatty Acid Receptor	Cardiovascular Disease Metabolic Disease
(R)-AM-1638 is a R-isomer of AM-1638 (HY-13467). AM-1638 is an orally active full agonist of GPR40 (EC₅₀: 0.16 μM) .

HY-N18235

(1Z)-Atractylodinol	Lipoxygenase	Inflammation/Immunology
(1Z)-Atractylodinol, an acetylenes compound, is a weak 5-lipoxygenase (5-LOX) inhibitor with an IC₅₀ of 17.8 μM. (1Z)-Atractylodinol can be used for the study of inflammatory diseases .

HY-N7988A

(E)-4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate	Drug Derivative	Inflammation/Immunology
(E)-4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate is a polyacetylene found in the rhizomes of Atractylodes lancea. (E)-4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate shows no inhibitory activity against 5-lipoxygenase and COX-1 in in vitro assays at tested concentrations .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W010066

3,4-Dihydroxyphenylglycol	Structural Classification Classification of Application Fields Endocrine diseases Metabolic Disease Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Disease markers Phenols Polyphenols Nervous System Disorder Disease Research Fields Source Classification	NO Synthase COX IKK
3,4-Dihydroxyphenylglycol is a phenolic compound and antioxidant. 3,4-Dihydroxyphenylglycol can be extracted from olive oil. 3,4-Dihydroxyphenylglycol downregulates the expression of proinflammatory enzymes (iNOS, COX-2) and prevents the degradation of IκBα. 3,4-Dihydroxyphenylglycol has antioxidant properties. 3,4-Dihydroxyphenylglycol has shown positive effects on frozen-thawed ram sperm. 3,4-Dihydroxyphenylglycol can be used in the study of inflammatory-related diseases (such as ulcerative colitis) and reproductive health (sperm cryopreservation) .

HY-W010066R

3,4-Dihydroxyphenylglycol (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Disease markers Phenols Polyphenols Endocrine diseases Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards NO Synthase COX IKK
3,4-Dihydroxyphenylglycol (Standard) is the analytical standard of 3,4-Dihydroxyphenylglycol (HY-W010066). This product is intended for research and analytical applications. 3,4-Dihydroxyphenylglycol is a phenolic compound and antioxidant. 3,4-Dihydroxyphenylglycol can be extracted from olive oil. 3,4-Dihydroxyphenylglycol downregulates the expression of proinflammatory enzymes (iNOS, COX-2) and prevents the degradation of IκBα. 3,4-Dihydroxyphenylglycol has antioxidant properties. 3,4-Dihydroxyphenylglycol has shown positive effects on frozen-thawed ram sperm. 3,4-Dihydroxyphenylglycol can be used in the study of inflammatory-related diseases (such as ulcerative colitis) and reproductive health (sperm cryopreservation) .

HY-N18235

(1Z)-Atractylodinol	Structural Classification Natural Products Plants Compositae Source Classification Erythrina sigmoidea Hua	Lipoxygenase
(1Z)-Atractylodinol, an acetylenes compound, is a weak 5-lipoxygenase (5-LOX) inhibitor with an IC₅₀ of 17.8 μM. (1Z)-Atractylodinol can be used for the study of inflammatory diseases .

HY-N7988A

(E)-4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate	Structural Classification Natural Products Plants Compositae Source Classification Erythrina sigmoidea Hua	Drug Derivative
(E)-4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate is a polyacetylene found in the rhizomes of Atractylodes lancea. (E)-4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate shows no inhibitory activity against 5-lipoxygenase and COX-1 in in vitro assays at tested concentrations .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702425

	RNF5 Protein, Human (Cell-Free, His) E3 ubiquitin-protein ligase RNF5; RING finger protein 5; RAM1 homolog; HsRma1	Human	E. coli Cell-free
	The RNF5 protein is a membrane-bound E3 ubiquitin protein ligase that is critical for ubiquitination of target proteins and can cooperate with UBE2D1/UBCH5A and UBE2D2/UBC4 to achieve ubiquitination over a broad substrate range. Notably, it mediates PXN/paxillin ubiquitination, affecting cell motility and cell positioning. RNF5 Protein, Human (Cell-Free, His) is the recombinant human-derived RNF5 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

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Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3)
Application:	IHC-P (2) ICC/IF (1) IP (1) WB (1) FC (1)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

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HY-P82461

	RAB27A Antibody (YA2206) GS2; RAM; RAB27; HsT18676	WB, ICC/IF, IP, FC	Human
	RAB27A Antibody (YA2206) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAB27A.

HY-P88290

	CDCA7L Antibody (YA7974) JPO2; R1; RAM2	IHC-P	Human
	CDCA7L Antibody (YA7974) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CDCA7L.

HY-P88290A

	CDCA7L Antibody (YA7974)(PBS only) JPO2; R1; RAM2	IHC-P	Human
	CDCA7L Antibody (YA7974) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CDCA7L.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-132593

Rovanersen WVE-120101		Antisense Oligonucleotides
Rovanersen (WVE-120101) is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of HTT gene, thereby preventing the production of faulty Huntingtin protein. Rovanersen can be used for huntington’s disease research .

HY-RS11537

RAB27A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
RAB27A Human Pre-designed siRNA Set A contains three designed siRNAs for RAB27A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-148412

Monarsen EN101; ODN 7040; BL 7040		Antisense Oligonucleotides
Monarsen (EN101) is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).

HY-RS11637

RAMAC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
RAMAC Human Pre-designed siRNA Set A contains three designed siRNAs for RAMAC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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