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Rovanersen (Synonyms: WVE-120101)

Cat. No.: HY-132593
Handling Instructions

Rovanersen (WVE-120101) is an antisense oligonucleotide that can be used for huntington’s disease research.

For research use only. We do not sell to patients.

Rovanersen Chemical Structure

Rovanersen Chemical Structure

CAS No. : 2072901-32-5

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Description

Rovanersen (WVE-120101) is an antisense oligonucleotide that can be used for huntington’s disease research[1].

In Vitro

In vitro, Rovanersen (WVE-120101) leads to the selective RNase H cleavage of mutant Huntingtin allele (mHTT) over wtHTT, with no complement activation. Rovanersen selectively decreases mHTT mRNA and protein levels compared with wtHTT in multiple cells lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In non-human primates (NHPs), Rovanersen (WVE-120101) is found in nuclear and perinuclear compartments of neurons in brain areas believed to be involved in HD pathology[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Rovanersen
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