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CDCA7L Antibody (YA7974)(PBS only)

(Synonyms: JPO2; R1; RAM2)

CDCA7L Antibody (YA7974) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CDCA7L.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • CDCA7L Antibody (YA7974)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

CDCA7L Antibody (YA7974) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CDCA7L.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 52 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 1-337 of human CDCA7L produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CDCA7L plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1

  • Subcellular Localization

    Cytoplasm,Nucleus

  • Expression


    Tissue_Specificity: Ubiquitous. Overexpressed in medulloblastoma
    Induction: By MYC overexpression in a concentration dependent manner in neuroblastoma cell line

  • Isoforms & Post-Translational Modification

    Q96GN5 has four isomers: Q96GN5-1: 52206 Da (predicted); Q96GN5-2: 52078 Da (predicted); Q96GN5-4: 48309 Da (predicted); Q96GN5-5: 46779 Da (predicted).
    Phosphorylation increases its interaction with PSIP1

  • Subunit

    Interacts with MYC (PubMed:15994933, PubMed:16829576)

  • SwissProt ID

    Q96GN5

  • Synonyms

    JPO2; R1; RAM2

CDCA7L Antibody (YA7974)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • CDCA7L Antibody (YA7974)(PBS only) Product Image