(R)-AM-1638
(R)-AM-1638 is a R-isomer of AM-1638 (HY-13467). AM-1638 is an orally active full agonist of GPR40 (EC50: 0.16 μM).
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- CAS No.: 1142222-18-1
- Formule: C33H35FO4
- Masse moléculaire:514.63
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
1.1 μM
Compound: 22
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Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
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[PMID: 24900539] |
| CHO | EC50 |
34 μM
Compound: 22
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Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serum
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[PMID: 24900539] |
Chemical Information
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CAS No. 1142222-18-1
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Masse moléculaire 514.63
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Formule C33H35FO4
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SMILES
FC1=CC=C(OC)C=C1C2=C(C3=CCCC3(C)C)C=C(C=C2)COC4=CC([C@@H](C5CC5)CC(O)=O)=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hwang HJ, et al. AM1638, a GPR40-Full Agonist, Inhibited Palmitate- Induced ROS Production and Endoplasmic Reticulum Stress, Enhancing HUVEC Viability in an NRF2-Dependent Manner. Endocrinol Metab (Seoul). 2023 Dec;38(6):760-769. [Content Brief]
[2]. Brown SP, et al. Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. ACS Med Chem Lett. 2018 Jun 6;9(7):757-760. [Content Brief]
[3]. Brown SP, et al. Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. ACS Med Chem Lett. 2012 Aug 15;3(9):726-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-AM-1638 Related Classifications
HY-13467A Related Classifications
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