1142222-18-1
1142222-18-1
Chemical Structure
(R)-AM-1638
- CAS No.: 1142222-18-1
- Formula:C33H35FO4
- Molecular Weight:514.63
InChIKey: CHEANNSDVJOIBS-HHHXNRCGSA-N
SMILES: FC1=CC=C(OC)C=C1C2=C(C3=CCCC3(C)C)C=C(C=C2)COC4=CC([C@@H](C5CC5)CC(O)=O)=CC=C4
Biological Activity: (R)-AM-1638 is a R-isomer of AM-1638 (HY-13467). AM-1638 is an orally active full agonist of GPR40 (EC50: 0.16 μM)[1][2][3].
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(R)-AM-1638 | (R)-AM-1638 is a R-isomer of AM-1638 (HY-13467). AM-1638 is an orally active full agonist of GPR40 (EC50: 0.16 μM). | |||||||||||||||||||||
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References
- [1]. Hwang HJ, et al. AM1638, a GPR40-Full Agonist, Inhibited Palmitate- Induced ROS Production and Endoplasmic Reticulum Stress, Enhancing HUVEC Viability in an NRF2-Dependent Manner. Endocrinol Metab (Seoul). 2023 Dec;38(6):760-769. [Content Brief]
- [2]. Brown SP, et al. Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. ACS Med Chem Lett. 2018 Jun 6;9(7):757-760. [Content Brief]
- [3]. Brown SP, et al. Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. ACS Med Chem Lett. 2012 Aug 15;3(9):726-30. [Content Brief]
Keywords
