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Results for "

Retinoid X receptors

" in MedChemExpress (MCE) Product Catalog:

39

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1

Fluorescent Dyes

1

Biochemical Assay Reagents

6

Natural
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7

Isotope-Labeled Compounds

1

GMP Molecules

Targets Recommended:
Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-14171
    Bexarotene
    Maximum Cited Publications
    22 Publications Verification

    LGD1069

    		 RAR/RXR Autophagy Cancer
    Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
    Bexarotene
  • HY-107500
    UVI 3003
    5+ Cited Publications

    		 RAR/RXR Autophagy Others
    UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively.
    UVI 3003
  • HY-15340
    LG100268
    5 Publications Verification

    LG268

    		 RAR/RXR Autophagy Metabolic Disease
    LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC50 values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 displays >1000-fold selectivity for RXR over RAR, the Ki values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy .
    LG100268
  • HY-107399
    CD3254
    3 Publications Verification

    		 RAR/RXR Metabolic Disease Cancer
    CD3254 a potent and selective retinoid-X-receptor (RXR) agonist .
    CD3254
  • HY-A0067
    Oxybenzone
    5+ Cited Publications

    Benzophenone 3

    		 Environmental Pollutants Autophagy RAR/RXR Apoptosis Neurological Disease
    Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
    Oxybenzone
  • HY-32350
    Ercalcitriol
    3 Publications Verification

    1α,25-Dihydroxy Vitamin D2

    		 VD/VDR Drug Metabolite Endogenous Metabolite Metabolic Disease
    Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .
    Ercalcitriol
  • HY-100008
    Peretinoin
    5+ Cited Publications

    NIK333

    		 RAR/RXR SphK Autophagy HCV Infection Cancer
    Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 . Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM .
    Peretinoin
  • HY-116506
    Bigelovin

    		RAR/RXR Reactive Oxygen Species (ROS) Apoptosis Autophagy Cancer
    Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .
    Bigelovin
  • HY-153832
    MSU-42011

    		RAR/RXR NO Synthase Cancer
    MSU-42011 is an orally active retinoid X receptor (RXR) agonist. MSU-42011 inhibits the iNOS activity and reduces the expression of p-ERK protein. MSU-42011 has immunomodulatory and antitumor activity .
    MSU-42011
  • HY-W107616
    3,7,11,15-Tetramethyl-2-hexadecen-1-ol

    		Endogenous Metabolite Others
    3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .
    3,7,11,15-Tetramethyl-2-hexadecen-1-ol
  • HY-120875
    HX600

    		RAR/RXR Neurological Disease
    HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity .
    HX600
  • HY-14171S
    Bexarotene-d4

    LGD1069 d4

    		 RAR/RXR Autophagy Cancer
    Bexarotene-d4 is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma .
    Bexarotene-d4
  • HY-A0067S
    Oxybenzone-d5

    		RAR/RXR Apoptosis Autophagy Neurological Disease
    Oxybenzone-d5 is the deuterium labeled Oxybenzone . Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
    Oxybenzone-d5
  • HY-108525
    Fluorobexarotene

    		RAR/RXR Cancer
    Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene .
    Fluorobexarotene
  • HY-104070
    LG-100064

    		RAR/RXR Autophagy Cancer
    LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.
    LG-100064
  • HY-144377
    RXR antagonist 1

    		RAR/RXR Neurological Disease Metabolic Disease Cancer
    RXR antagonist 1 (compound 6a) is a retinoid X receptor (RXR) modulator. RXR antagonist 1 shows potent RXR-antagonistic activity, with a pA2 of 8.06. RXR antagonist 1 can be used for type 2 diabetes research .
    RXR antagonist 1
  • HY-155437
    NEt-iFQ

    		RAR/RXR Others
    NEt-iFQ is a fluorescent retinoid X receptor (RXR) agonist with potent solvatochromic properties. NEt-iFQ selectively binds to RXR-LBP and fluoresces .
    NEt-iFQ
  • HY-117376
    (all-E)-UAB30

    UAB30

    		 RAR/RXR Cancer
    (all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC50 of 34.7, 5.1, and 22.4 μM respectively .
    (all-E)-UAB30
  • HY-A0067R
    Oxybenzone (Standard)

    Benzophenone 3 (Standard)

    		 Reference Standards RAR/RXR Autophagy Apoptosis Neurological Disease
    Oxybenzone (Standard) is the analytical standard of Oxybenzone. This product is intended for research and analytical applications. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
    Oxybenzone (Standard)
  • HY-160212
    JP3000

    		RAR/RXR Metabolic Disease
    JP3000, a chemical probe, is an agonist of RXRA, RXRB, RXRG .
    JP3000
  • HY-N2992
    16α-Hydroxytrametenolic acid

    		RAR/RXR Cancer
    16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist .
    16α-Hydroxytrametenolic acid
  • HY-177890
    UAB116

    		LXR RAR/RXR Wnt β-catenin Cancer
    UAB116 is a Liver X Receptor (LXR)/Retinoid X Receptor (RXR) agonist. UAB116 can decreases metastatic phenotype in hepatoblastoma by inhibiting the Wnt/β-Catenin pathway via upregulation of TRIM29. UAB116 can reduce proliferation, stemness and invasiveness of metastatic hepatoblastoma cells .
    UAB116
  • HY-175480
    RXR agonist 2

    		RAR/RXR Neurological Disease Metabolic Disease
    RXR agonist 2 (Compound 22) is a highly selective retinoid X receptor (RXR) agonist (EC50=0.039 μM). RXR agonist 2 is promising for research of metabolic syndrome and Alzheimer's disease .
    RXR agonist 2
  • HY-100008R
    Peretinoin (Standard)

    NIK333 (Standard)

    		 Reference Standards RAR/RXR SphK Autophagy HCV Infection Cancer
    Peretinoin (Standard) is the analytical standard of Peretinoin. This product is intended for research and analytical applications. Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].
    Peretinoin (Standard)
  • HY-117182
    LG190178

    		Apoptosis VD/VDR RAR/RXR Metabolic Disease Inflammation/Immunology Cancer
    LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer .
    LG190178
  • HY-14171S2
    Bexarotene-13C6

    LGD1069-13C6

    		 Isotope-Labeled Compounds RAR/RXR Autophagy Cancer
    Bexarotene- 13C6 (LGD1069- 13C6) is 13C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
    Bexarotene-13C6
  • HY-14171R
    Bexarotene (Standard)

    LGD1069 (Standard)

    		 Reference Standards RAR/RXR Autophagy Cancer
    Bexarotene (Standard) is the analytical standard of Bexarotene. This product is intended for research and analytical applications. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
    Bexarotene (Standard)
  • HY-W777169
    Bexarotene-13C4

    LGD1069-13C4

    		 Isotope-Labeled Compounds RAR/RXR Autophagy Cancer
    Bexarotene- 13C4 (LGD1069- 13C4) is the 13C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
    Bexarotene-13C4
  • HY-A0067S1
    Oxybenzone-13C6

    Benzophenone 3-13C6

    		 Isotope-Labeled Compounds RAR/RXR Autophagy Apoptosis Neurological Disease
    Oxybenzone- 13C6 (Benzophenone 3- 13C6) is the 13C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
    Oxybenzone-13C6
  • HY-W653958
    Oxybenzone-d3

    Benzophenone 3-d3

    		 Isotope-Labeled Compounds RAR/RXR Autophagy Apoptosis Neurological Disease
    Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
    Oxybenzone-d3
  • HY-15340R
    LG100268 (Standard)

    LG268 (Standard)

    		 RAR/RXR Autophagy Reference Standards Metabolic Disease
    LG100268 (Standard) is the analytical standard of LG100268. This product is intended for research and analytical applications. LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC50 values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 displays >1000-fold selectivity for RXR over RAR, the Ki values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy .
    LG100268 (Standard)
  • HY-32350S1
    Ercalcitriol-d3

    1α,25-Dihydroxy Vitamin D2-d3

    		 Isotope-Labeled Compounds Endogenous Metabolite VD/VDR Metabolic Disease
    Ercalcitriol-d3 (1α,25-Dihydroxy Vitamin D2-d3) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .
    Ercalcitriol-d3
  • HY-107399R
    CD3254 (Standard)

    		Reference Standards RAR/RXR Metabolic Disease Cancer
    CD3254 (Standard) is the analytical standard of CD3254 (HY-107399). This product is intended for research and analytical applications. CD3254 a potent and selective retinoid-X-receptor (RXR) agonist .
    CD3254 (Standard)
  • HY-N19756
    Cochinchinone P

    		RAR/RXR Cancer
    Cochinchinone P is a retinoid X receptor-α (RXRα) inhibitor that inhibits 9-cis-retinoic acid (HY-15128)-induced transcriptional activity of RXRα in vitro. Cochinchinone P can be used in cancer research .
    Cochinchinone P
  • HY-107500R
    UVI 3003 (Standard)

    		Reference Standards RAR/RXR Autophagy Others
    UVI 3003 (Standard) is the analytical standard of UVI 3003 (HY-107500). This product is intended for research and analytical applications. UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively.
    UVI 3003 (Standard)
  • HY-104070R
    LG-100064 (Standard)

    		Reference Standards RAR/RXR Autophagy Cancer
    LG-100064 (Standard) is the analytical standard of LG-100064 (HY-104070). This product is intended for research and analytical applications. LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.
    LG-100064 (Standard)
  • HY-180181
    RXR antagonist 6

    		RAR/RXR Metabolic Disease Cancer
    RXR antagonist 6 (Compound 34) is a selective partial retinoid X receptor (RXR) antagonist. RXR antagonist 6 shows no agonistic activity for any of the human RXRα/β/γ subtypes but it can strongly inhibit the receptor activation induced by full agonists of RXR (such as Bezafibrate (HY-B0637)) with an IC50 of 2.7 μM. RXR antagonist 6 can enhance PMA (HY-18739)-induced THP-1 cell differentiation. RXR antagonist 6 can be used for the research of cancer, metabolic and neurological disease, such as lymphoma .
    RXR antagonist 6
  • HY-W107616R
    3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard)

    		Endogenous Metabolite Reference Standards Others
    3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard) is the analytical standard of 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (HY-W107616). This product is intended for research and analytical applications. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .
    3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard)
  • HY-107413G
    SR11237

    		RAR/RXR Tyrosine Hydroxylase Neurological Disease Inflammation/Immunology
    SR11237 GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease .
    SR11237

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