calcium-sensing

By Targets:	CaSR (22) Endogenous Metabolite (1) Fluorescent Dye (3) mGluR (1) TNF Receptor (1) Wnt (1)
By Research Areas:	Cardiovascular Disease (3) Endocrinology (8) Inflammation/Immunology (3) Metabolic Disease (8) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

Targets Recommended: CaSR Calcium Channel Calmodulin CRAC Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-50713

Calcium-Sensing Receptor Antagonists I	CaSR	Others
Calcium-Sensing Receptor Antagonists I is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103314

Gadolinium chloride GdCl3	CaSR	Cardiovascular Disease
Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease .

HY-109106A

Upacicalcet sodium	CaSR	Endocrinology
Upacicalcet sodium is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT) .

HY-109106B

(Rac)-Upacicalcet	CaSR	Endocrinology
(Rac)-Upacicalcet is the racemate of Upacicalcet.Upacicalcet is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT) .

HY-109106

Upacicalcet	CaSR	Endocrinology
Upacicalcet is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT) .

HY-117851

AC-265347	CaSR	Metabolic Disease Endocrinology
AC-265347 is a calcium-sensing receptor (CaSR) agonist and positive allosteric modulator (ago-PAM) with the functional affinity (pK_B) of 5.1. AC-265347 can be used for the research of hyperparathyroidism and related diseases .

HY-122819

Calindol hydrochloride	CaSR	Cardiovascular Disease
Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC₅₀ of 132 nM .

HY-15105

SB-423562

CaSR Inflammation/Immunology

SB-423562 is a short-acting calcium-sensing receptor (CaR) antagonist. SB-423562 has the potential for osteoporosis research.

SB-423562	CaSR	Inflammation/Immunology
SB-423562 is a short-acting calcium-sensing receptor (CaR) antagonist. SB-423562 has the potential for osteoporosis research.

HY-11095

NPS 2390	mGluR CaSR	Cardiovascular Disease Neurological Disease
NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5 . NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor .

HY-N0546

Ligustroflavone Nuezhenoside	CaSR	Metabolic Disease
Ligustroflavone, extracted from Ligustrum lucidum, is a potential candidate as calcium-sensing receptor (CaSR) antagonist. Ligustroflavone exhibits protective effects against diabetic osteoporosis in mice .

HY-10167A

Tecalcet Hydrochloride 3 Publications Verification R-568 hydrochloride	CaSR	Others
Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca ²⁺ .

HY-14752

Ronacaleret SB 751689	CaSR	Metabolic Disease Endocrinology
Ronacaleret (SB 751689) is an orally active, potent, and selective calcium-sensing receptor (CaSR) antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret (SB 751689) is used for the study of postmenopausal osteoporosis .

HY-15104

Ronacaleret hydrochloride SB 751689A	CaSR	Metabolic Disease Endocrinology
Ronacaleret hydrochloride (SB 751689A) is an orally active, potent, and selective calcium-sensing receptor (CaSR) antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret hydrochloride (SB 751689A) is used for the study of postmenopausal osteoporosis .

HY-112171

γ-L-Glutamyl-L-alanine 1 Publications Verification	Endogenous Metabolite CaSR	Others
γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function .

HY-15106

SB-423557	CaSR	Metabolic Disease Inflammation/Immunology
SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC₅₀=520 nM), precursor of SB-423562 (IC₅₀=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation .

HY-17397

Strontium Ranelate 2 Publications Verification Distrontium renelate; S12911	CaSR	Metabolic Disease
Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling .

HY-12557

γ-Glutamylvaline	CaSR Wnt TNF Receptor	Inflammation/Immunology
γ-Glutamylvaline is an activator of CaSR with anti-inflammatory activity. γ-Glutamylvaline inhibits TNF-α-induced proinflammatory cytokine production and increases Wnt5a expression. γ-Glutamylvaline activates calcium-sensing receptor pathways in adipocytes of 3T3-L1 mice and prevents low-grade chronic inflammation .

HY-P4376

Gamma-Glu-Abu

CaSR Neurological Disease

Gamma-Glu-Abu is a potent calcium sensing receptor (CaSR) agonist .

Gamma-Glu-Abu	CaSR	Neurological Disease
Gamma-Glu-Abu is a potent calcium sensing receptor (CaSR) agonist .

HY-P1955

Etelcalcetide AMG 416; KAI-4169	CaSR	Endocrinology
Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis .

HY-P1955A

Etelcalcetide hydrochloride AMG 416 hydrochloride; KAI-4169 hydrochloride	CaSR	Endocrinology
Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis .

HY-17613

Evocalcet 1 Publications Verification KHK7580	CaSR	Metabolic Disease
Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

HY-153258

CaSR antagonist-1	CaSR	Metabolic Disease
CaSR antagonist-1 is a calcium sensing receptor (CaSR) antagonist with an IC₅₀ value of 50 nM. CaSR antagonist-1 can be used for the research of disorders associated with abnormal bone or mineral homeostasis such as osteoporosis .

HY-135367

pyCTZ Pyridyl CTZ	Fluorescent Dye	Others
pyCTZ (Pyridyl CTZ), a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ generates strong blue bioluminescence in the presence of luciferases. pyCTZ can be used for aequorin-based calcium sensing .

HY-135367B

pyCTZ hydrochloride Pyridyl CTZ hydrochloride	Fluorescent Dye	Others
pyCTZ (Pyridyl CTZ) hydrochloride, a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ hydrochloride generates strong blue bioluminescence in the presence of luciferases. pyCTZ hydrochloride can be used for aequorin-based calcium sensing .

HY-135367A

pyCTZ TFA Pyridyl CTZ TFA	Fluorescent Dye	Others
pyCTZ (Pyridyl CTZ) TFA, a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ TFA generates strong blue bioluminescence in the presence of luciferases. pyCTZ TFA can be used for aequorin-based calcium sensing .

Cat. No.	Product Name	Type

HY-135367

pyCTZ Pyridyl CTZ	Fluorescent Dyes/Probes
pyCTZ (Pyridyl CTZ), a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ generates strong blue bioluminescence in the presence of luciferases. pyCTZ can be used for aequorin-based calcium sensing .

Cat. No.	Product Name	Target	Research Area

HY-12557

γ-Glutamylvaline	CaSR Wnt TNF Receptor	Inflammation/Immunology
γ-Glutamylvaline is an activator of CaSR with anti-inflammatory activity. γ-Glutamylvaline inhibits TNF-α-induced proinflammatory cytokine production and increases Wnt5a expression. γ-Glutamylvaline activates calcium-sensing receptor pathways in adipocytes of 3T3-L1 mice and prevents low-grade chronic inflammation .

HY-P1955A

Etelcalcetide hydrochloride AMG 416 hydrochloride; KAI-4169 hydrochloride	CaSR	Endocrinology
Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis .

HY-P4376

Gamma-Glu-Abu

CaSR Neurological Disease

Gamma-Glu-Abu is a potent calcium sensing receptor (CaSR) agonist .

Gamma-Glu-Abu	CaSR	Neurological Disease
Gamma-Glu-Abu is a potent calcium sensing receptor (CaSR) agonist .

HY-P1955

Etelcalcetide AMG 416; KAI-4169	CaSR	Endocrinology
Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0546

Ligustroflavone Nuezhenoside	Flavonoids Classification of Application Fields Oleaceae Flavones Ligustrum lucidum Ait. Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	CaSR
Ligustroflavone, extracted from Ligustrum lucidum, is a potential candidate as calcium-sensing receptor (CaSR) antagonist. Ligustroflavone exhibits protective effects against diabetic osteoporosis in mice .

HY-112171

γ-L-Glutamyl-L-alanine 1 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite CaSR
γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function .

Cat. No.	Compare	Product Name	Species	Source

HY-P79408

	Calcium-sensing R/CaSR Protein, Human (HEK293, His) Extracellular calcium-sensing receptor; CASR; CaR; hCasR; Parathyroid cell calcium-sensing receptor 1; PCaR1; calcium-sensing Receptor	Human	HEK293
	Calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that is essential for maintaining calcium homeostasis. It senses changes in extracellular calcium concentration, regulates parathyroid hormone (PTH) production, and activates the phosphatidylinositol-calcium second messenger system. Calcium-sensing R/CaSR Protein, Human (HEK293, His) is the recombinant human-derived Calcium-sensing R/CaSR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Calcium-sensing R/CaSR Protein, Human (HEK293, His) is 582 a.a., with molecular weight of approximately 95-130 kDa.


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Cat. No.	Product Name		Classification

HY-50713

Calcium-Sensing Receptor Antagonists I		Alkynes
Calcium-Sensing Receptor Antagonists I is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Click Chemistry

calcium-sensing

Inhibitors & Agonists

Fluorescent Dye

Peptides

NaturalProducts

Recombinant Proteins

Click Chemistry

Natural
Products