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  3. SB-423557

SB-423557 

Cat. No.: HY-15106
Handling Instructions

SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation.

For research use only. We do not sell to patients.

SB-423557 Chemical Structure

SB-423557 Chemical Structure

CAS No. : 351490-26-1

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Description

SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation[1].

IC50 & Target

IC50: 520 nM (Calcium-sensing receptor)[1]

In Vivo

SB-423557 (oral administration; 10, 30 or 100 μM/kg; once daily; 12 weeks) elicits transient increases in plasma concentrations of PTH, resulting in increased bone mass and strength in both vertebrae and long bones compared to that of OVX controls[1].

Molecular Weight

464.60

Formula

C₂₈H₃₆N₂O₄

CAS No.

351490-26-1

SMILES

O=C(OCC)CCC1=CC=C(C#N)C(OC[[email protected]](O)CNC(C)(C)CC2CC3=C(C=CC=C3)C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SB-423557
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