2. GPCR/G Protein
  3. CaSR
  4. Calindol hydrochloride

Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.

For research use only. We do not sell to patients.

Calindol hydrochloride Chemical Structure

Calindol hydrochloride Chemical Structure

CAS No. : 729610-18-8

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Based on 1 publication(s) in Google Scholar

Calindol hydrochloride Related Antibodies

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Description

Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM[1].

In Vitro

In the presence of 2mM Ca2+, Calindol stimulates phosphatidylinositol (PI) accumulation with an EC50 of 1.0 μM or 0.31 μM in cells expressing the rat or the human CaSR, respectively[2].
In wire myography studies, Calindol (1-10 µM) inhibits Methoxamine- and KCl-induced pre-contracted tone, and inhibits whole-cell voltage-gated Ca2+ channel (VGCC) currents in rabbit mesenteric arteries[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Calindol hydrochloride Related Antibodies
Molecular Weight

336.86

Formula

C21H21ClN2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

C[C@@H](NCC1=CC2=CC=CC=C2N1)C3=C4C=CC=CC4=CC=C3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (296.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9686 mL 14.8430 mL 29.6859 mL
5 mM 0.5937 mL 2.9686 mL 5.9372 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9686 mL 14.8430 mL 29.6859 mL 74.2148 mL
5 mM 0.5937 mL 2.9686 mL 5.9372 mL 14.8430 mL
10 mM 0.2969 mL 1.4843 mL 2.9686 mL 7.4215 mL
15 mM 0.1979 mL 0.9895 mL 1.9791 mL 4.9477 mL
20 mM 0.1484 mL 0.7421 mL 1.4843 mL 3.7107 mL
25 mM 0.1187 mL 0.5937 mL 1.1874 mL 2.9686 mL
30 mM 0.0990 mL 0.4948 mL 0.9895 mL 2.4738 mL
40 mM 0.0742 mL 0.3711 mL 0.7421 mL 1.8554 mL
50 mM 0.0594 mL 0.2969 mL 0.5937 mL 1.4843 mL
60 mM 0.0495 mL 0.2474 mL 0.4948 mL 1.2369 mL
80 mM 0.0371 mL 0.1855 mL 0.3711 mL 0.9277 mL
100 mM 0.0297 mL 0.1484 mL 0.2969 mL 0.7421 mL
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Calindol hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Calindol729610-18-8CaSRCalcium-sensing receptorpositive allosteric modulatorPAMphosphatidylinositolInhibitorinhibitorinhibit

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