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Pathways Recommended: Antibody-drug Conjugate/ADC Related
Results for "

folate conjugate

" in MedChemExpress (MCE) Product Catalog:

29

Inhibitors & Agonists

12

Biochemical Assay Reagents

2

Peptides

3

Inhibitory Antibodies

1

Natural
Products

1

Click Chemistry

7

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-132258A
    Mirvetuximab soravtansine (solution)
    3 Publications Verification

    IMGN853 (solution)

    		 Antibody-Drug Conjugates (ADCs) Antifolate Cancer
    Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α (FRα) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A, and the drug-linker conjugate for ADC is sulfo-SPDB-DM4 (HY-101141). Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage .
    Mirvetuximab soravtansine (solution)
  • HY-W053583
    Tetraxetan
    1 Publications Verification

    DOTA

    		 Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Cancer
    Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., 68Ga, 111In, 177Lu). Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folate receptor-positive tumors (e.g., cervical cancer) .
    Tetraxetan
  • HY-P99612
    Farletuzumab ecteribulin

    MORAb-202

    		 Antibody-Drug Conjugates (ADCs) Cancer
    Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folate receptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.
    Farletuzumab ecteribulin
  • HY-155882
    mPEG750-amine

    mPEG750-NH2

    		 Biochemical Assay Reagents Cancer
    mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
    mPEG750-amine
  • HY-W006064
    L-Propargylglycine
    1 Publications Verification

    (S)-2-Aminopent-4-ynoic acid

    		 Amino Acid Derivatives Others
    (S)-2-Aminopent-4-ynoic acid is a synthetic amino acid. (S)-2-Aminopent-4-ynoic acid can be used in synthesis of folate-conjugates and corresponding metal-chelate complexes . (S)-2-Aminopent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    L-Propargylglycine
  • HY-P10762
    Ricorfotide vedotin

    CBP-1008; LDC 10B

    		 Peptide-Drug Conjugates (PDCs) Folate Receptor (FR) TRP Channel Cancer
    Ricorfotide vedotin (CBP-1008) is a dual-ligand peptide-drug conjugate (PDC) conjugated to MMAE (HY-15162), targeting Folate receptor α (FRα) and TRPV6. Ricorfotide vedotin binds to FRα with high affinity and TRPV6 with low affinity. Ricorfotide vedotin has antitumor activity, and can be used in advanced solid tumor research (eg: colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma and follicular dendritic cell sarcoma) .
    Ricorfotide vedotin
  • HY-155883
    mPEG3400-amine

    mPEG3400-NH2

    		 Biochemical Assay Reagents Cancer
    mPEG3400-amine can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).
    mPEG3400-amine
  • HY-155884
    mPEG4000-amine

    mPEG4000-NH2

    		 Biochemical Assay Reagents Cancer
    mPEG4000-amine can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).
    mPEG4000-amine
  • HY-155880
    mPEG350-amine

    mPEG350-NH2

    		 Biochemical Assay Reagents Cancer
    mPEG350-amine can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).
    mPEG350-amine
  • HY-W053583R
    Tetraxetan (Standard)

    DOTA (Standard)

    		 Biochemical Assay Reagents Reference Standards Radionuclide-Drug Conjugates (RDCs) Cancer
    Tetraxetan (Standard) is the analytical standard of Tetraxetan (HY-W053583). This product is intended for research and analytical applications. Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., 68Ga, 111In, 177Lu). Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folate receptor-positive tumors (e.g., cervical cancer) .
    Tetraxetan (Standard)
  • HY-W591632
    PEG-bis-amine (MW 1000)

    Poly(ethylene glycol)-bis-amine (MW 1000)

    		 Biochemical Assay Reagents Cancer
    PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).
    PEG-bis-amine (MW 1000)
  • HY-W115607
    PEG4000-bis-amine

    Poly(ethylene glycol)-bis-amine 4000

    		 Biochemical Assay Reagents Cancer
    PEG4000-bis-amine synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).
    PEG4000-bis-amine
  • HY-172351A
    PEG6000-bis-amine

    		Biochemical Assay Reagents Cancer
    PEG6000-bis-amine synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent Rubitecan (HY-16560) .
    PEG6000-bis-amine
  • HY-172351B
    PEG10000-bis-amine

    		Biochemical Assay Reagents Cancer
    PEG10000-bis-amine synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent Rubitecan (HY-16560) .
    PEG10000-bis-amine
  • HY-W1113135
    Carboxymethyl-β-cyclodextrin sodium salt

    		Biochemical Assay Reagents Others
    Carboxymethyl-β-cyclodextrin sodium salt is a negatively charged β-cyclodextrin derivative, as well as a metal ion chelator and solubilizing reagent. Carboxymethyl-β-cyclodextrin sodium salt forms stable aqueous complexes with Ba 2+, Ca 2+, Cd 2+, Ni 2+, Pb 2+, Sr 2+, and Zn 2+ ions. Carboxymethyl-β-cyclodextrin sodium salt derived hydrogel carriers support oral insulin delivery via paracellular permeation across Caco-2 monolayers and produce sustained hypoglycemic effects in diabetic mice. Carboxymethyl-β-cyclodextrin sodium salt can be conjugated onto folate-modified BSA nanoparticles to boost folate receptor-mediated endocytosis, elevate intracellular anticancer drug uptake and trigger cell apoptosis. Carboxymethyl-β-cyclodextrin sodium salt can be utilized for chiral separation in capillary electrophoresis, development of nanoscale drug carriers and nucleic acid transfection research .
    Carboxymethyl-β-cyclodextrin sodium salt
  • HY-16181
    EC-0225

    		Folate Receptor (FR) Microtubule/Tubulin DNA Alkylator/Crosslinker Cancer
    EC-0225, a folate conjugate of two agents- one a potent microtubule inhibiting agent, and the second a DNA alkylating agent. EC-0225 inhibits the growth of folate receptor (FR)-positive KB cells with an IC50 of ~1 nM. EC-0225 can be selectively delivered to advanced FR-positive tumors without causing overt toxicity, such as lung carcinoma .
    EC-0225
  • HY-128940
    EC089

    		ADC Linker Cancer
    EC089 is a cleavable linker used in conjugates of tubulysins and folates, and extracted from patent WO2011069116A1 .
    EC089
  • HY-138484
    Folate-PEG3-amine

    		ADC Linker Cancer
    Folate-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Folate-PEG3-amine
  • HY-172351
    PEG400-bis-amine

    		Biochemical Assay Reagents Cancer
    PEG400-bis-amine synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent Rubitecan (HY-16560) .
    PEG400-bis-amine
  • HY-W440715
    Cholesterol-PEG2000-Folate

    		Liposome Others
    Cholesterol-PEG2000-Folate is an excipient and can be used for the preparation of folate-conjugated PEG-liposomes .
    Cholesterol-PEG2000-Folate
  • HY-128937
    EC1454

    		Liposome Folate Receptor (FR) Cancer
    EC1454 is a peptide compound with anticancer activity that targets folate receptor-expressing cancers. EC1454 is a folate-tubulysin conjugate that can be used to prepare drug delivery conjugates for targeted therapy .
    EC1454
  • HY-129880
    Desacetylvinblastine hydrazide

    Deacetylvinblastine hydrazide; DAVLBH

    		 Microtubule/Tubulin Cancer
    Desacetylvinblastine hydrazide (Deacetylvinblastine hydrazide; DAVLBH) is an active component of EC145, a folate-targeted drug conjugate. Desacetylvinblastine hydrazide interferes with the formation of the mitotic spindle, and thus inhibits cell division and leads to cell death. Desacetylvinblastine hydrazide exhibits antitumor activity against folate receptor (FR)-positive tumor .
    Desacetylvinblastine hydrazide
  • HY-180461
    EET analog 7

    		Drug Derivative Cancer
    EET analog 7 is an epoxyeicosatrienoic acid (EET) analog that can be conjugated with folate receptor ligands to target kidney cells expressing high levels of folate receptors. EET analog 7 can be used for constructing kidney-targeted drug conjugates .
    EET analog 7
  • HY-185427
    Opugotamig olatansine

    IMGN-151

    		 Antibody-Drug Conjugates (ADCs) Folate Receptor (FR) Cancer
    Opugotamig olatansine (IMGN151) is a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC). Opugotamig olatansine comprises antibody Opugotamig (HY-P990935) and linker-payload NMS-P945 (HY-185569). Opugotamig olatansine binds to two independent epitopes of FRα and promotes antibody binding, internalization, and processing. Opugotamig olatansine can be used for the research of FRα-positive ovarian cancer .
    Opugotamig olatansine
  • HY-N16022
    N-TETAMINE-pSar45-Folate

    		Biochemical Assay Reagents Others
    N-TETAMINE-pSar45-Folate is a lipid that is composed of a Folic acid (HY-16637) unit conjugated to a N-TETAMINE-pSar45. N-TETAMINE-pSar45-Folate can be used to prepare lipid nanoparticles for drug delivery.
    N-TETAMINE-pSar45-Folate
  • HY-P992124
    Onvontatug

    BAT8006 Antibody; BAT-6028

    		 Folate Receptor (FR) Cancer
    Onvontatug (BAT8006 Antibody) is a humanized monoclonal antibody targeting folate receptor α (FRα). Onvontatug can be used to construct antibody-drug conjugates (ADCs), such as BAT8006. It is applicable to research related to platinum-resistant ovarian cancer .
    Onvontatug
  • HY-180557
    4A-BFA-11

    		Folate Receptor (FR) Cancer
    4A-BFA-11 is a folate-targeted PEG-MMAE conjugate that exhibits specific binding affinity for the folate receptor α (FR-α) (KD = 106.7 nM). 4A-BFA-11 achieves tumor enrichment by combining PEG-mediated long circulation (EPR effect) and folate receptor targeting. 4A-BFA-11 undergoes enzymatic cleavage at the tumor site to release the active payload, enabling precise action. 4A-BFA-11 sefficiently carries, targets, and controls the release of MMAE in tumor tissues in a HeLa mouse model. 4A-BFA-11 can be used for cervical cancer, ovarian cancer, and lung cancer research .
    4A-BFA-11
  • HY-P992002
    AMT-151 Antibody

    		ADC Antibody Cancer
    AMT-151 Antibody is a monoclonal antibody inhibitor targeting folate receptor α. AMT-151 Antibody can be used to synthesize the antibody-drug conjugate (ADC) AMT-151. AMT-151 Antibody can be used to research related to cancer .
    AMT-151 Antibody
  • HY-P992003
    IKS012 Antibody

    IKS01 Antibody

    		 ADC Antibody Cancer
    IKS012 (IKS01) Antibody is a monoclonal antibody inhibitor targeting folate receptor α (FRA). IKS012 Antibody can be used to synthesize the antibody-drug conjugate (ADC) IKS012. IKS012 Antibody can be used to research related to platinum-resistant ovarian cancer .
    IKS012 Antibody

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