2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Farletuzumab ecteribulin

Farletuzumab ecteribulin  (Synonyms: MORAb-202)

Cat. No.: HY-P99612 Purity: 97.87%
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Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folate receptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.

For research use only. We do not sell to patients.

Farletuzumab ecteribulin Chemical Structure

Farletuzumab ecteribulin Chemical Structure

CAS No. : 2407465-18-1

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Farletuzumab ecteribulin Related Antibodies

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Description

Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folate receptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.

In Vitro

Farletuzumab ecteribulin (MORAb-202; 5.1 pM-10 μM; 5?days) is highly cytotoxic to FRA-positive cells in vitro (IGROV-1: IC50=1 nM, NCI-H2110: IC50=74 nM, A431-A3: IC50=2.3 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Farletuzumab ecteribulin Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Human IGROV-1, OVCAR3-A1, NCI-H2110, A431-A3, and SJSA-1 cells
Concentration: 5.1 pM-10 μM
Incubation Time: 5 days
Result: MORAb-202 showed potent cytotoxicity against IGROV-1 (IC50=1 nM), NCI-H2110 (IC50=74 nM), and A431-A3 (IC50=2.3 μM).
Exhibited little killing activity against the FRA-negative cell line SJSA-1 (IC50>10 μM).
In Vivo

Farletuzumab ecteribulin (MORAb-202; IV; single injection 1, 5?mg/kg at day 0 or 5?mg/kg every 11 days; 60 days) has a significant antitumor activity with once or twice 5 mg/kg[1].
Farletuzumab ecteribulin (2mg/kg; IV) has a T1/2s of 192 and 162 hours and AUC(0-t)s of 7160 and 6300 ug·h/mL for male and female cynomolgus monkeys on Day 1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SWISS nude mice with triple-negative breast cancer (TNBC) patient-derived xenograft (PDx) model (OD-BRE-0631)[1].
Dosage: 1, 5 mg/kg
Administration: IV; single injection 1, 5 mg/kg at day 0 ((Q1Dx1) or 5 mg/kg every 11 days (Q11Dx2)); 60 days
Result: A significant antitumor activity was observed in mice treated once or twice 5 mg/kg, while no antitumor activity compared with vehicle group was observed in mice treated with 1 mg/kg.
Animal Model: Male and female cynomolgus monkeys[1].
Dosage: 2mg/kg (Pharmacokinetic Analysis)
Administration: IV
Result: Had a T1/2s of 192 and 162 hours and AUC(0-t)s of 7160 and 6300 ug·h/mL for male and female cynomolgus monkeys on Day 1.
Clinical Trial
Molecular Weight

149000.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Farletuzumab ecteribulin]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Farletuzumab ecteribulin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Farletuzumab ecteribulin2407465-18-1MORAb-202MORAb202MORAb 202Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesantibody-drug conjugateADCfolate receptor alphaFRAFarletuzumabMal-PEG2-Val-Cit-PAB-eribulinantitumorInhibitorinhibitorinhibit

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