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Cat. No.: HY-172351B

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PEG10000-bis-amine

PEG10000-bis-amine is a bisamine-terminated polyethylene glycol that serves as a key starting material for the preparation of cholesterol-conjugated polyethylene glycol derivatives. After radioiodination modification, PEG10000-bis-amine significantly prolongs plasma retention time and exhibits enhanced tumor accumulation in a subcutaneous melanoma mouse model. PEG10000-bis-amine has important application value in studies of tumor-targeted delivery and drug modification.

For research use only. We do not sell to patients.

CAS No.: 24991-53-5
Molecular Weight:10000 (Average)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PEG10000-bis-amine Chemical Structure

CAS No.: 24991-53-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

In Vivo

¹²⁵I-labeled PEG10000-bis-amine (1.4 mg/kg; i.v.; single dose) demonstrates prolonged blood circulation and tumor accumulation in mice bearing subcutaneous B16F10 melanoma, with higher blood and tumor levels than PEG5000 at all time points measured^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57 black (male)^[1]
Dosage:

1.4 mg/kg
Administration:

i.v.; single dose
Result:

Showed 2.7% dose/mL in blood, 1.19% dose/g in tumor, 4.34% dose/g in liver, 0.58% dose/g in heart, 0.47% dose/g in spleen, 0.90% dose/g in lungs, and 1.57% dose/g in kidneys at 1 hour post-administration.
Showed 1.22% dose/mL in blood, 1.06% dose/g in tumor, 3.89% dose/g in liver, 0.18% dose/g in heart, 0.26% dose/g in spleen, 0.39% dose/g in lungs, and 0.74% dose/g in kidneys at 5 hours post-administration.
Showed 0.57% dose/mL in blood, 0.26% dose/g in tumor, 1.79% dose/g in liver, 0.08% dose/g in heart, 0.16% dose/g in spleen, 0.19% dose/g in lungs, and 0.20% dose/g in kidneys at 24 hours post-administration.

Chemical Information

CAS No. 24991-53-5
Molecular Weight 10000 (Average)
SMILES

NCCOCCOCCN.[n]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Veronese FM, Schiavon O, Pasut G, et al.. PEG-doxorubicin conjugates: influence of polymer structure on drug release, in vitro cytotoxicity, biodistribution, and antitumor activity. Bioconjugate chemistry. 2005;16(4):775-84. [Content Brief]

[2]. Madenspacher J H, et al. Dyslipidemia induces opposing effects on intrapulmonary and extrapulmonary host defense through divergent TLR response phenotypes[J]. The Journal of Immunology, 2010, 185(3): 1660-1669.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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