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  4. PEG10000-bis-amine

PEG10000-bis-amine is a bisamine-terminated polyethylene glycol that serves as a key starting material for the preparation of cholesterol-conjugated polyethylene glycol derivatives. After radioiodination modification, PEG10000-bis-amine significantly prolongs plasma retention time and exhibits enhanced tumor accumulation in a subcutaneous melanoma mouse model. PEG10000-bis-amine has important application value in studies of tumor-targeted delivery and drug modification.

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PEG10000-bis-amine

PEG10000-bis-amine Chemical Structure

CAS No. : 24991-53-5

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Description

PEG10000-bis-amine is a bisamine-terminated polyethylene glycol that serves as a key starting material for the preparation of cholesterol-conjugated polyethylene glycol derivatives. After radioiodination modification, PEG10000-bis-amine significantly prolongs plasma retention time and exhibits enhanced tumor accumulation in a subcutaneous melanoma mouse model. PEG10000-bis-amine has important application value in studies of tumor-targeted delivery and drug modification[1][2].

In Vivo

125I-labeled PEG10000-bis-amine (1.4 mg/kg; i.v.; single dose) demonstrates prolonged blood circulation and tumor accumulation in mice bearing subcutaneous B16F10 melanoma, with higher blood and tumor levels than PEG5000 at all time points measured[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57 black (male)[1]
Dosage: 1.4 mg/kg
Administration: i.v.; single dose
Result: Showed 2.7% dose/mL in blood, 1.19% dose/g in tumor, 4.34% dose/g in liver, 0.58% dose/g in heart, 0.47% dose/g in spleen, 0.90% dose/g in lungs, and 1.57% dose/g in kidneys at 1 hour post-administration.
Showed 1.22% dose/mL in blood, 1.06% dose/g in tumor, 3.89% dose/g in liver, 0.18% dose/g in heart, 0.26% dose/g in spleen, 0.39% dose/g in lungs, and 0.74% dose/g in kidneys at 5 hours post-administration.
Showed 0.57% dose/mL in blood, 0.26% dose/g in tumor, 1.79% dose/g in liver, 0.08% dose/g in heart, 0.16% dose/g in spleen, 0.19% dose/g in lungs, and 0.20% dose/g in kidneys at 24 hours post-administration.
Molecular Weight

10000 (Average)

CAS No.
SMILES

NCCOCCOCCN.[n]
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PEG10000-bis-amine24991-53-5Biochemical Assay Reagentspoly(ethylene glycol)melanomacholesteryl-conjugated PEG derivativesB16F10 melanomamiceInhibitorinhibitorinhibit

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PEG10000-bis-amine
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HY-172351B
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