PEG6000-bis-amine
PEG6000-bis-amine is a diamine-terminated polyethylene glycol (MW≈6000) and conjugate linker. PEG6000-bis-amine endows the surface of carbon capsules with stealth properties, biocompatibility, and free amino groups for antibody conjugation. PEG6000-bis-amine acts as a reducing agent and passivating agent to promote the formation and assembly of silver nanoparticles on silica nanospheres, and increases the number of silver nanoparticles on the silica surface.
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- CAS. Nr.: 24991-53-5
- Molecular Weight:6000 (Average)
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
PEG6000-bis-amine-modified carbon capsules coloaded with Y2O3:Eu3+(5%) and GdF3:Tb3+(10%) (50-200 μg/mL; 18 h) exhibit minimal cytotoxicity, supporting >80% proliferation in HeLa, A498, L929, HepG2, and MM418 cell lines at concentrations up to 200 μg/mL after 18 h incubation[1].
PEG6000-bis-amine-modified carbon capsules coloaded with Y2O3:Eu3+(5%) and GdF3:Tb3+(10%) (100 μg/mL; 18 h) are internalized by HeLa, A498, L929, HepG2, and MM418 cells primarily via caveolae/raft-mediated endocytosis, with significant uptake observed at 100 μg/mL after 18 h incubation[1].
PEG6000-bis-amine (6 mM; 1 h) effectively mediates the synthesis and assembly of uniform, aggregated silver nanoparticles on MPTS-treated silica nanospheres at 25 °C, producing an average of 19.1 Ag NPs (24.9 nm average size) per silica nanosphere[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, A498, L929, HepG2, MM418
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Concentration:50-200 μg/mL
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Incubation Time:18 h
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Result:Supported >80% proliferation in all tested cell lines at concentrations up to 200 μg/mL, indicating minimal cytotoxicity.
Chemical Information
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CAS. Nr. 24991-53-5
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Molecular Weight 6000 (Average)
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SMILES
NCCOCCOCCN.[n]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Rammohan A, Mishra G, Mahaling B, et al.. PEGylated Carbon Nanocapsule: A Universal Reactor and Carrier for In Vivo Delivery of Hydrophobic and Hydrophilic Nanoparticles. ACS applied materials & interfaces. 2016 Jan 13;8(1):350-62. [Content Brief]
[2]. Kang H, Yim J, Jeong S, et al.. Polymer-mediated formation and assembly of silver nanoparticles on silica nanospheres for sensitive surface-enhanced Raman scattering detection. ACS applied materials & interfaces. 2013 Dec 26;5(24):12804-10. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PEG6000-bis-amine Related Classifications
HY-172351A Related Classifications
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