2. Cell Cycle/DNA Damage
  3. Folate Receptor (FR)
  4. 4A-BFA-11

4A-BFA-11 is a folate-targeted PEG-MMAE conjugate that exhibits specific binding affinity for the folate receptor α (FR-α) (KD = 106.7 nM). 4A-BFA-11 achieves tumor enrichment by combining PEG-mediated long circulation (EPR effect) and folate receptor targeting. 4A-BFA-11 undergoes enzymatic cleavage at the tumor site to release the active payload, enabling precise action. 4A-BFA-11 sefficiently carries, targets, and controls the release of MMAE in tumor tissues in a HeLa mouse model. 4A-BFA-11 can be used for cervical cancer, ovarian cancer, and lung cancer research.

For research use only. We do not sell to patients.

4A-BFA-11

4A-BFA-11 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

4A-BFA-11 Related Antibodies

Top Publications Citing Use of Products

View All Folate Receptor (FR) Isoform Specific Products:

View All Isoforms
FR-α

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

4A-BFA-11 is a folate-targeted PEG-MMAE conjugate that exhibits specific binding affinity for the folate receptor α (FR-α) (KD = 106.7 nM). 4A-BFA-11 achieves tumor enrichment by combining PEG-mediated long circulation (EPR effect) and folate receptor targeting. 4A-BFA-11 undergoes enzymatic cleavage at the tumor site to release the active payload, enabling precise action. 4A-BFA-11 sefficiently carries, targets, and controls the release of MMAE in tumor tissues in a HeLa mouse model. 4A-BFA-11 can be used for cervical cancer, ovarian cancer, and lung cancer research[1].

IC50 & Target[1]

FR-α

106.7 nM (Kd)

In Vitro

4A-BFA-11 (72 h) exhibits antiproliferation activity in HeLa, SK-OV-3, and A549 cells, with IC50s of 37.62, 28.8, and 15.1 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4A-BFA-11 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 Cmax AUC0-t AUC0-∞ Vz-F_obs CL/F
Mice[1] 1.5 mg/kg i.v. 3.04 h 6783.19 ng/mL 21168.40 ng·h/mL 21352.07 ng·h/mL 229.71 mL/kg 70.41 mL/h/kg
In Vivo

4A-BFA-11 (0.4 and 0.8 mg/kg, i.v., once weekly for 2 weeks) inhibits tumor growth in a HeLa mouse cervical cancer model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (5-6 weeks) inoculated with HeLa graft tumors in the right axilla[1]
Dosage: 0.4 and 0.8 mg/kg
Administration: i.v., once weekly for 2 weeks
Result: Resulted in stronger antitumor effects with a tumor growth inhibition rate (T/C%) of 67.1% at 0.4 mg/kg.
Achieved pronounced antitumor effects with a T/C% of 95.9% at 0.8 mg/kg.
Showed no significant body weight loss and no significant changes in blood parameters.
Induced mild hepatitis at 0.4 mg/kg, characterized by trace inflammatory cell infiltration predominantly composed of lymphocytes and granulocytes.
Exhibited mild sinusoidal dilatation in the spleen, and the low-dose group showed slight adhesion of the white pulp.
Molecular Weight

2349.72

Formula

C113H173N23O31
SMILES

O=C(NCCOCCOCC(NCCOCCOCCOCCNC(CC[C@@H](C(O)=O)NC(C1=CC=C(C=C1)NCC2=NC(C(NC(N)=N3)=O)=C3N=C2)=O)=O)=O)COCCOCCNC([C@@H](CCC(N[C@@H](C(C)C)C(N[C@H](CCCNC(N)=O)C(N(C)C4=CC=C(C=C4)COC(N([C@H](C(N[C@H](C(N(C)[C@@H]([C@H](CC)C)[C@@H](CC(N5[C@@H](CCC5)[C@@H]([C@H](C(N[C@@H]([C@H](C6=CC=CC=C6)O)C)=O)C)OC)=O)OC)=O)C(C)C)=O)C(C)C)C)=O)=O)=O)=O)NC(CCCCCN7C(CCC7=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

4A-BFA-11 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4A-BFA-11Folate Receptor (FR)folate receptor αMMAEPEG-mediated long circulationHeLaSK-OV-3A549cervical cancerovarian cancerlung cancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
4A-BFA-11
Cat. No.:
HY-180557
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.