Carboxymethyl-β-cyclodextrin sodium salt

Carboxymethyl-β-cyclodextrin (CMCD) (0-100 g/L; 2 hours, 7 days, 1-19.5 hours) sodium salt, for capillary electrophoresis increases the solubility of BaC₂O₄, CaC₂O₄, CdC₂O₄, NiC₂O₄, PbC₂O₄, SrSO₄ and ZnC₂O₄ at 10 °C and 25 °C, with conditional formation constants ranging from 3.48 to 5.18^[1].
Carboxymethyl-β-cyclodextrin sodium salt is successfully grafted onto carboxymethyl chitosan via an EDC/NHS-mediated amidation reaction to form amorphous porous hydrogel microparticles^[2].
Carboxymethyl-β-cyclodextrin sodium salt grafted carboxymethyl chitosan hydrogel microparticles exhibit pH-dependent swelling properties. Their hydrophilic groups and porous structure enable a maximum swelling ratio of up to 437%, and an insulin loading capacity of 30.00-31.90% can be achieved via the swelling diffusion method; 92% of the loaded insulin remains after 2 h of incubation, and the microparticles show pH-responsive release behavior; in addition, they allow insulin to permeate through the Caco-2 cell monolayer^[2].
Carboxymethyl-β-cyclodextrin grafted carboxymethyl chitosan hydrogel microparticles (12.5-1600 μg/mL; 24 h at 37°C) sodium salt, for capillary electrophoresis show no cytotoxicity against Caco-2 cells^[2].
Blank BSA nanoparticles prepared with Carboxymethyl-β-cyclodextrin sodium salt show no obvious cytotoxicity to Hela and SMMC-7721 cells. Nanoparticles of the same system loaded with 5-Fu reduce cell viability in a dose-dependent manner, with a more significant inhibitory effect on folate receptor-positive Hela cells. Only weak non-specific uptake of the nanoparticles occurs in the two types of tumor cells^[3].
5-Fu-loaded BSA nanoparticles constructed with Carboxymethyl-β-cyclodextrin sodium salt downregulate intracellular ATP, upregulate the expression of activated caspase-3 protein without altering the expression level of Bax protein after 48 h incubation with Hela cells, and induce Hela cell apoptosis through synergistic multiple effects^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.