2828447-14-7
Chemical Structure
Carboxymethyl-β-cyclodextrin sodium salt
- CAS No.: 2828447-14-7
- Formula:C56H84NaO49·xNa
- Molecular Weight:1541.24 (Average)
SMILES: OC(COC[C@@H](O[C@@](O[C@](C1O)([H])[C@H](O[C@@](O[C@]([C@@H]2O)([H])[C@H](O[C@@](O[C@]([C@@H]([C@H]3O)O)([H])[C@H]4COCC(O)=O)([H])[C@@H]2O)COCC(O)=O)([H])[C@@H]1O)COCC(O)=O)([H])[C@@H]5O)[C@@](C5O)([H])O[C@@]([C@@H](C6O)O)([H])O[C@@H]([C@@]6([H])O[C@@]([C@@H](C7O)O)([H])O[C@@H]([C@@]7([H])O[C@@]([C@@H](C8O)O)([H])O[C@@H]([C@@]8([H])O[C@@]3([H])O4)COCC(O)=O)COCC(O)=O)COCC(O)=O)=O.[x].[Na]
Biological Activity: Carboxymethyl-β-cyclodextrin sodium salt is a negatively charged β-cyclodextrin derivative, as well as a metal ion chelator and solubilizing reagent. Carboxymethyl-β-cyclodextrin sodium salt forms stable aqueous complexes with Ba2+, Ca2+, Cd2+, Ni2+, Pb2+, Sr2+, and Zn2+ ions. Carboxymethyl-β-cyclodextrin sodium salt derived hydrogel carriers support oral insulin delivery via paracellular permeation across Caco-2 monolayers and produce sustained hypoglycemic effects in diabetic mice. Carboxymethyl-β-cyclodextrin sodium salt can be conjugated onto folate-modified BSA nanoparticles to boost folate receptor-mediated endocytosis, elevate intracellular anticancer drug uptake and trigger cell apoptosis. Carboxymethyl-β-cyclodextrin sodium salt can be utilized for chiral separation in capillary electrophoresis, development of nanoscale drug carriers and nucleic acid transfection research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Carboxymethyl-β-cyclodextrin sodium salt | 99.6% | Carboxymethyl-β-cyclodextrin sodium salt is a negatively charged β-cyclodextrin derivative, as well as a metal ion chelator and solubilizing reagent. Carboxymethyl-β-cyclodextrin sodium salt forms stable aqueous complexes with Ba2+, Ca2+, Cd2+, Ni2+, Pb2+, Sr2+, and Zn2+ ions. Carboxymethyl-β-cyclodextrin sodium salt derived hydrogel carriers support oral insulin delivery via paracellular permeation across Caco-2 monolayers and produce sustained hypoglycemic effects in diabetic mice. Carboxymethyl-β-cyclodextrin sodium salt can be conjugated onto folate-modified BSA nanoparticles to boost folate receptor-mediated endocytosis, elevate intracellular anticancer drug uptake and trigger cell apoptosis. Carboxymethyl-β-cyclodextrin sodium salt can be utilized for chiral separation in capillary electrophoresis, development of nanoscale drug carriers and nucleic acid transfection research. | ||||||||||||||||||||
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Carboxymethyl-β-cyclodextrin sodium salt, for capillary electrophoresis | Carboxymethyl-β-cyclodextrin sodium salt, for capillary electrophoresis is a negatively charged β-cyclodextrin derivative, as well as a metal ion chelator and solubilizing reagent. Carboxymethyl-β-cyclodextrin sodium salt, for capillary electrophoresis forms stable aqueous complexes with Ba2+, Ca2+, Cd2+, Ni2+, Pb2+, Sr2+, and Zn2+ ions. Carboxymethyl-β-cyclodextrin sodium salt derived hydrogel carriers support oral insulin delivery via paracellular permeation across Caco-2 monolayers and produce sustained hypoglycemic effects in diabetic mice. Carboxymethyl-β-cyclodextrin sodium salt can be conjugated onto folate-modified BSA nanoparticles to boost folate receptor-mediated endocytosis, elevate intracellular anticancer drug uptake and trigger cell apoptosis. Carboxymethyl-β-cyclodextrin sodium salt can be utilized for chiral separation in capillary electrophoresis, development of nanoscale drug carriers and nucleic acid transfection research. | |||||||||||||||||||||
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- [1]. Skold ME, et al. Solubility enhancement of seven metal contaminants using carboxymethyl-beta-cyclodextrin (CMCD). J Contam Hydrol. 2009;107(3-4):108-113. [Content Brief]
- [2]. Yang Y, et al. Carboxymethyl β-cyclodextrin grafted carboxymethyl chitosan hydrogel-based microparticles for oral insulin delivery. Carbohydr Polym. 2020;246:116617. [Content Brief]
- [3]. Su C, et al. Carboxymethyl-β-cyclodextrin conjugated nanoparticles facilitate therapy for folate receptor-positive tumor with the mediation of folic acid. Int J Pharm. 2014;474(1-2):202-211. [Content Brief]
