2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Folate Receptor (FR)
  4. Opugotamig olatansine

Opugotamig olatansine (IMGN151) is a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC). Opugotamig olatansine comprises antibody Opugotamig (HY-P990935) and linker-payload NMS-P945 (HY-185569). Opugotamig olatansine binds to two independent epitopes of FRα and promotes antibody binding, internalization, and processing. Opugotamig olatansine can be used for the research of FRα-positive ovarian cancer.

For research use only. We do not sell to patients.

Opugotamig olatansine

Opugotamig olatansine Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Opugotamig olatansine Related Antibodies

Top Publications Citing Use of Products

View All Folate Receptor (FR) Isoform Specific Products:

View All Isoforms
FR-α

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Opugotamig olatansine (IMGN151) is a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC). Opugotamig olatansine comprises antibody Opugotamig (HY-P990935) and linker-payload NMS-P945 (HY-185569). Opugotamig olatansine binds to two independent epitopes of FRα and promotes antibody binding, internalization, and processing. Opugotamig olatansine can be used for the research of FRα-positive ovarian cancer[1].

In Vitro

Opugotamig olatansine boosts antibody binding events and processing by 100% in JHOS4 medium FRα expression tumor cells and by 170% in KB high FRα expression tumor cells compared to parent monospecific antibodies[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Opugotamig olatansine Related Antibodies
SMILES

[Opugotamig olatansine]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Opugotamig olatansine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Opugotamig olatansineIMGN-151IMGN151IMGN 151Antibody-Drug Conjugates (ADCs)Folate Receptor (FR)Antibody-Drug ConjugatesKBtumor cellsFRαJHOS4antibody-drug conjugate internalizationovarian cancer modelsFolate Receptor alphacynomolgus monkey modelsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Opugotamig olatansine
Cat. No.:
HY-185427
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.