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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
isolated rat hearts
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "isolated rat hearts" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-18071
CAS No.: 1204329-34-9
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BI-9627, a chemical probe, is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC50 = 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays). BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 decreases autophagy in HTR-8/SVneo cells. BI-9627 can significantly reduce the pHi of human sperm and partially reverse the effect of DMA. BI-9627 prolongs Ca 2+ recovery time in KO hiPSC-CMs. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .
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4 Cited Publications
Cat. No.: HY-18071A
CAS No.: 1422252-46-7
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BI-9627 hydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC50 = 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays). BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride decreases autophagy in HTR-8/SVneo cells. BI-9627 hydrochloride can significantly reduce the pHi of human sperm and partially reverse the effect of DMA. BI-9627 hydrochloride prolongs Ca 2+ recovery time in KO hiPSC-CMs. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .
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1 Cited Publications
Cat. No.: HY-N6020B
CAS No.: 21913-99-5
Category:
Cardiovascular Disease Dalbergia odorifera T. Chen Flavonoids Leguminosae Flavonones Phenols Polyphenols Plants Disease Research Fields
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1 Cited Publications
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SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research .
Cat. No.: HY-W016733
CAS No.: 13594-51-9
Synonyms: H-D-Cit-OH
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Cat. No.: HY-P1573
CAS No.: 123337-89-3
Synonyms: BNP-45, rat
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Cat. No.: HY-163120
CAS No.: 849011-39-8
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Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research .
Cat. No.: HY-160076
CAS No.: 2049973-39-7
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APJ receptor agonist 8 (compound 99) is an agonist of APJ receptor. APJ receptor agonist 8 increases the load independent cardiac contractility of isolated perfused rat hearts .
Cat. No.: HY-105362
CAS No.: 162412-71-7
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PD 155080 is a selective endothelin A receptor (ETA receptor) antagonist. PD 155080 reduces coronary resistance in the isolated rat heart model. PD 155080 improves myocardial systolic function and diastolic function in the ischemia/reperfusion model. PD 155080 can be used for the study of cardiovascular diseases .
Cat. No.: HY-113322
CAS No.: 53467-23-5
Synonyms: 3-Hydroxyquinidine
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3-Hydroxyquinine is a metabolite of Quinidine (HY-B1751). 3-Hydroxyquinine prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in an isolated rat heart reperfusion arrhythmia model in a concentration-dependent manner. 3-Hydroxyquinine can be used in the study of cardiac arrhythmias .
Cat. No.: HY-P1573A
Synonyms: BNP-45, rat TFA
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Cat. No.: HY-130748
CAS No.: 105114-22-5
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K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC50=350 nM). It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC50=46.2 μM).
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Cat. No.: HY-N6020BR
CAS No.: 21913-99-5
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Cat. No.: HY-B0887BR
CAS No.: 54774-47-9
Synonyms: (-)-trans-NRDC-143 (Standard); (1S)-trans-Permethrin (Standard)
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Cat. No.: HY-P1428A
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Cat. No.: HY-163735
CAS No.: 609335-29-7
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BA6b9 is an allosteric inhibitor of SK4 channels that targets the CaM–PIP2-binding domain with a IC50 value of 8.6 µM (WT SK4). BA6b9 inhibits SK4 channels by interacting with two specific residues, Arg191 and His192 in the S4–S5 linker. BA6b9 significantly prolongs atrial and atrioventricular effective refractory period (ERP) and reduces atrial fibrillation (AF) induction in rat isolated hearts, which has the potential to be used for the research of arrhythmia .
Cat. No.: HY-181063
CAS No.: 899207-91-1
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Nav1.5-IN-1 is a selective Nav1.5 inhibitor with an IC50 of 1.38 μM. Nav1.5-IN-1 shows selectivity over other Nav subtypes. Nav1.5-IN-1 reduces cardiac conduction in isolated rat hearts.Nav1.5-IN-1 can be used for the research of arrhythmias .
Cat. No.: HY-121864
CAS No.: 909708-65-2
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Liguzinediol is a protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor that enhances the activity of sarcoplasmic reticulum Ca 2+-ATPase (SERCA2a). Liguzinediol reduces the dephosphorylation level of phospholamban and increases the phosphorylation levels of phospholamban at serine-16 and threonine-17 sites. Liguzinediol exerts positive inotropic effects in rat hearts both in vivo and in vitro, and reverses caffeine-induced decrease in myocardial contractility in isolated rat hearts. Liguzinediol can be used for the research of heart failure .
Cat. No.: HY-183433
CAS No.: 99435-38-8
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Ph CL 28A is a prostaglandin 15-hydroxydehydrogenase (15-PGDH) inhibitor. Ph CL 28A increases the output of PGE2, PGF2α and endogenous arachidonic acid-derived PGI2 in isolated rat lungs, reduces the output of TxB2 and LTC4 in isolated rat hearts, and exhibits protective effects in rat models of inflammation and gastric mucosal injury. Ph CL 28A can be used in research related to acute inflammation and gastric ulcers .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
