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Cat. No.: HY-130748

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K-252d

K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC₅₀=350 nM). It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC₅₀=46.2 μM).

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CAS No.: 105114-22-5
Formule: C₂₆H₂₃N₃O₅
Masse moléculaire:457.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

K-252d Chemical Structure

CAS No.: 105114-22-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-120497

PKCζ-IN-1

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform PKC :

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE) :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	9 μM Compound: 6; K252d	Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 30106291]
K562	IC₅₀	>100 μM Compound: 6; K252d	Cytotoxicity against human K562 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human K562 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 30106291]
L02	IC₅₀	73.8 μM Compound: 6; K252d	Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 30106291]

Chemical Information

CAS No. 105114-22-5
Masse moléculaire 457.48
Formule C₂₆H₂₃N₃O₅
SMILES

O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)N([C@H]6[C@@H]([C@@H]([C@H]([C@H](C)O6)O)O)O)C7=C3C=CC=C7
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nakanishi, et al. K-252b, c and d, potent inhibitors of protein kinase C from microbial origin. J. Antibiot. (Tokyo) 39(8), 1066-1071 (1986).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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K-252d

PKCζ-IN-1

Voir tous les produits spécifiques à Isoform PKC

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

K-252d Related Classifications

HY-130748 Related Classifications