Nav1.5-IN-1
Nav1.5-IN-1 is a selective Nav1.5 inhibitor with an IC50 of 1.38 μM. Nav1.5-IN-1 shows selectivity over other Nav subtypes. Nav1.5-IN-1 reduces cardiac conduction in isolated rat hearts.Nav1.5-IN-1 can be used for the research of arrhythmias.
For research use only. We do not sell to patients.
- CAS No.: 899207-91-1
- Formula: C36H36ClN3O4S
- Molecular Weight:642.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Nav1.5 1.38 μM (IC50) |
Nav1.5-IN-1 (KH2) potently inhibits wild-type human Nav1.5 in HEK293T cells with an IC50 of 1.38 μM and shows selectivity over other Nav subtypes[1].
Nav1.5-IN-1 (KH2) (500 ns) binds stably to the central cavity pocket of human Nav1.5 in MD simulations, with critical interactions involving residues C896, L931, and F1760[1].
Nav1.5-IN-1 (KH2) weakly inhibits hERG currents in HEK293T cells with an IC50 of 10.32 μM and does not significantly inhibit Kir2.1 at 20 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (8-week-old)[1]
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Dosage:35 mg/kg
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Administration:i.p.; single dose
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Result:Showed no behavioral abnormalities in open-field (total distance traveled, time in central zone) or forced swim (immobility time) tests compared to controls.
Chemical Information
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CAS No. 899207-91-1
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Molecular Weight 642.21
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Formula C36H36ClN3O4S
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SMILES
O=C(C1=CC2=C(S(=O)(C3=CC=CC=C3C(N2CC4=CC(Cl)=CC=C4)=O)=O)C=C1)NCCCN5CCC(CC5)CC6=CC=CC=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nav1.5-IN-1 Related Classifications
HY-181063 Related Classifications
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