Nav1.5-IN-1 

Nav1.5-IN-1 is a selective Nav1.5 inhibitor with an IC₅₀ of 1.38 μM. Nav1.5-IN-1 shows selectivity over other Nav subtypes. Nav1.5-IN-1 reduces cardiac conduction in isolated rat hearts.Nav1.5-IN-1 can be used for the research of arrhythmias^[1].

Nav1.5-IN-1 (KH2) potently inhibits wild-type human Nav1.5 in HEK293T cells with an IC₅₀ of 1.38 μM and shows selectivity over other Nav subtypes^[1].
Nav1.5-IN-1 (KH2) (500 ns) binds stably to the central cavity pocket of human Nav1.5 in MD simulations, with critical interactions involving residues C896, L931, and F1760^[1].
Nav1.5-IN-1 (KH2) weakly inhibits hERG currents in HEK293T cells with an IC₅₀ of 10.32 μM and does not significantly inhibit Kir2.1 at 20 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nav1.5-IN-1 (KH2) (35 mg/kg; i.p.; single dose) does not induce acute systemic or neurobehavioral toxicity in 8-week-old mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

642.21

C₃₆H₃₆ClN₃O₄S

899207-91-1

O=C(C1=CC2=C(S(=O)(C3=CC=CC=C3C(N2CC4=CC(Cl)=CC=C4)=O)=O)C=C1)NCCCN5CCC(CC5)CC6=CC=CC=C6

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• [1]. Wang YY, et al. Discovery of a novel Na_v1.5 inhibitor reducing cardiac conduction via structure-based virtual screening and assays. Acta Pharmacol Sin. Published online January 1, 2026.  [Content Brief]