1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. SKA-111

SKA-111 

Cat. No.: HY-100418 Purity: 99.97%
COA Handling Instructions

SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research.

For research use only. We do not sell to patients.

SKA-111 Chemical Structure

SKA-111 Chemical Structure

CAS No. : 1369170-24-0

Size Price Stock Quantity
5 mg USD 190 In-stock
10 mg USD 320 In-stock
25 mg USD 640 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research[1].

In Vitro

SKA-111 (1 μM, 5 min) evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell[1].
SKA-111 (1 μM, 5 min) induces significantly augmented the Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in large porcine coronary arteries (PCA) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SKA-111 (1 μM for cardiac perfusion) improves Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Langendorff in rat hearts [1]
Dosage: 1 μM
Administration: Cardiac perfusion
Result: Potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.
Molecular Weight

214.29

Formula

C12H10N2S

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=NC2=C3C=CC=CC3=C(C)C=C2S1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (466.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6666 mL 23.3329 mL 46.6657 mL
5 mM 0.9333 mL 4.6666 mL 9.3331 mL
10 mM 0.4667 mL 2.3333 mL 4.6666 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.67 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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SKA-111 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SKA-111
Cat. No.:
HY-100418
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