SKA-111

Cat. No.: HY-100418 Purity: 99.97%: FAQs
Data Sheet SDS COA Handling Instructions

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SKA-111 is a selective activator of potassium phannel K_Ca3.1 , evokes K_Ca3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research.

For research use only. We do not sell to patients.

SKA-111 Chemical Structure

CAS No. : 1369170-24-0

Size	Price	Stock	Quantity
5 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 640	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

In Vitro

SKA-111 (1 μM, 5 min) evokes K_Ca3.1 membrane hyperpolarization in porcine endothelial cell^[1].
SKA-111 (1 μM, 5 min) induces significantly augmented the Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in large porcine coronary arteries (PCA) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SKA-111 (1 μM for cardiac perfusion) improves Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Langendorff in rat hearts ^[1]
Dosage:	1 μM
Administration:	Cardiac perfusion
Result:	Potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.

Molecular Weight

214.29

Formula

C₁₂H₁₀N₂S

CAS No.

1369170-24-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=NC2=C3C=CC=CC3=C(C)C=C2S1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (466.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6666 mL	23.3329 mL	46.6657 mL
5 mM	0.9333 mL	4.6666 mL	9.3331 mL
10 mM	0.4667 mL	2.3333 mL	4.6666 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (253 KB) HNMR (243 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6666 mL	23.3329 mL	46.6657 mL	116.6643 mL
	5 mM	0.9333 mL	4.6666 mL	9.3331 mL	23.3329 mL
	10 mM	0.4667 mL	2.3333 mL	4.6666 mL	11.6664 mL
	15 mM	0.3111 mL	1.5555 mL	3.1110 mL	7.7776 mL
	20 mM	0.2333 mL	1.1666 mL	2.3333 mL	5.8332 mL
	25 mM	0.1867 mL	0.9333 mL	1.8666 mL	4.6666 mL
	30 mM	0.1556 mL	0.7778 mL	1.5555 mL	3.8888 mL
	40 mM	0.1167 mL	0.5833 mL	1.1666 mL	2.9166 mL
	50 mM	0.0933 mL	0.4667 mL	0.9333 mL	2.3333 mL
	60 mM	0.0778 mL	0.3889 mL	0.7778 mL	1.9444 mL
	80 mM	0.0583 mL	0.2917 mL	0.5833 mL	1.4583 mL
	100 mM	0.0467 mL	0.2333 mL	0.4667 mL	1.1666 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKA-1111369170-24-0SKA111SKA 111Inhibitorinhibitorinhibit

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