Myosin-IN-1

Cat. No.: HY-163120 Purity: 98.14%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research.

For research use only. We do not sell to patients.

Myosin-IN-1 Chemical Structure

CAS No. : 849011-39-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Description

Molecular Weight

296.41

Formula

C₁₂H₁₆N₄OS₂

CAS No.

849011-39-8

Appearance

Solid

Color

White to light yellow

SMILES

O=C1C2=C(N=CN1NC(NC(C)C)=S)SC(CC)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 350 mg/mL (1180.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3737 mL	16.8685 mL	33.7371 mL
5 mM	0.6747 mL	3.3737 mL	6.7474 mL
10 mM	0.3374 mL	1.6869 mL	3.3737 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.14%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (245 KB) HNMR (165 KB) RP-HPLC (243 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Parijat P, et al. Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening. Nat Commun. 2023 Nov 24;14(1):7692. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3737 mL	16.8685 mL	33.7371 mL	84.3426 mL
	5 mM	0.6747 mL	3.3737 mL	6.7474 mL	16.8685 mL
	10 mM	0.3374 mL	1.6869 mL	3.3737 mL	8.4343 mL
	15 mM	0.2249 mL	1.1246 mL	2.2491 mL	5.6228 mL
	20 mM	0.1687 mL	0.8434 mL	1.6869 mL	4.2171 mL
	25 mM	0.1349 mL	0.6747 mL	1.3495 mL	3.3737 mL
	30 mM	0.1125 mL	0.5623 mL	1.1246 mL	2.8114 mL
	40 mM	0.0843 mL	0.4217 mL	0.8434 mL	2.1086 mL
	50 mM	0.0675 mL	0.3374 mL	0.6747 mL	1.6869 mL
	60 mM	0.0562 mL	0.2811 mL	0.5623 mL	1.4057 mL
	80 mM	0.0422 mL	0.2109 mL	0.4217 mL	1.0543 mL
	100 mM	0.0337 mL	0.1687 mL	0.3374 mL	0.8434 mL

Myosin-IN-1 Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Myosin-IN-1849011-39-8Myosincardiac-specific myosinInhibitorinhibitorinhibit

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Myosin-IN-1

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