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lipopolysaccharide-induced nitric oxide production

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NO Synthase (3) Drug Derivative (1) NF-κB (1)
By Research Areas:	Inflammation/Immunology (7)

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Targets Recommended: NO Synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9675

(+)-Hannokinol	NO Synthase	Inflammation/Immunology
(+)-Hannokinol can be isolated from AMOMUM TSAO-KO (ginger family) fruit. (+)-Hannokinol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

HY-N19813

Flaccidoside VI	NO Synthase	Others
Flaccidoside VI is an inhibitor of nitric oxide production belonging to oleanane-type triterpenoid saponins. Flaccidoside VI can be isolated from the rhizomes of Anemone flaccida. Flaccidoside VI exhibits significant inhibitory activity against lipopolysaccharide-induced nitric oxide production .

HY-N13098

Elatoside F	NF-κB	Inflammation/Immunology
Elatoside F is a triterpenoid saponin with anti-inflammatory activity. Elatoside F inhibits lipopolysaccharide-induced nitric oxide production and nuclear factor NF-κB activation. Elatoside F can be isolated from Aralia elata in one step.

HY-N12429

Marstenacisside F1	Others	Inflammation/Immunology
Marstenacisside F1 (compound 1) is a polyoxypregnanoside with anti-inflammatory activity isolated from Marsdenia tenacissima. Marstenacisside F1 inhibits lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells and is a derivative of Tenacigenin B.

HY-N3814

ent-16β,17-Dihydroxykauran-19-oic acid	Others	Inflammation/Immunology
ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

HY-N2132A

(E/Z)-Flavokawain B (E/Z)-Flavokavain B	Drug Derivative	Inflammation/Immunology
(E/Z)-Flavokawain B (compound 4) is a chalcone and nitric oxide production inhibitor with an IC₅₀ of 6.8 μM.(E/Z)-Flavokawain B can be found in the aerial parts of Sarcandra glabra.(E/Z)-Flavokawain B inhibits lipopolysaccharide-induced nitric oxide production .

HY-N19645

(-)-3-[2-(Acetyloxy)propyl]-2-hydroxy-8-methoxy-1,4-naphthoquinone	Others	Inflammation/Immunology
(-)-3--2-hydroxy-8-methoxy-1,4-naphthoquinone (Compound 1) is a naphthoquinone compound. (-)-3--2-hydroxy-8-methoxy-1,4-naphthoquinone is isolated from the bulbs of Eleutherine americana. (-)-3--2-hydroxy-8-methoxy-1,4-naphthoquinone shows no activity against lipopolysaccharide-induced nitric oxide production .

HY-W011592

N-Phthaloyl-L-glutamic acid	NO Synthase	Inflammation/Immunology
N-Phthaloyl-L-glutamic acid is an orally active anti-inflammatory agent. N-Phthaloyl-L-glutamic acid inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced nitric oxide production in murine spleen cells. N-Phthaloyl-L-glutamic acid does not exhibit significant cytotoxicity in vitro against tumor cells and BALB/c mice spleen cell culture. N-Phthaloyl-L-glutamic acid can be used for the research of inflammation .

(+)-Hannokinol	Structural Classification Amomum tsaoko Crevost et Lemarie Phenols Polyphenols Plants Source Classification Zingiberaceae	NO Synthase
(+)-Hannokinol can be isolated from AMOMUM TSAO-KO (ginger family) fruit. (+)-Hannokinol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

Flaccidoside VI	Triterpenes Structural Classification Anemone flaccida Fr. Schmidt Terpenoids Ranunculaceae Plants Source Classification	NO Synthase
Flaccidoside VI is an inhibitor of nitric oxide production belonging to oleanane-type triterpenoid saponins. Flaccidoside VI can be isolated from the rhizomes of Anemone flaccida. Flaccidoside VI exhibits significant inhibitory activity against lipopolysaccharide-induced nitric oxide production .

Elatoside F	Triterpenes Terpenoids Aralia elata (Miq.) Seem. Plants Araliaceae Source Classification	NF-κB
Elatoside F is a triterpenoid saponin with anti-inflammatory activity. Elatoside F inhibits lipopolysaccharide-induced nitric oxide production and nuclear factor NF-κB activation. Elatoside F can be isolated from Aralia elata in one step.

Marstenacisside F1	Structural Classification Marsdenia tenacissima (Roxb.) Moon Asclepiadaceae Plants Steroids Source Classification	Others
Marstenacisside F1 (compound 1) is a polyoxypregnanoside with anti-inflammatory activity isolated from Marsdenia tenacissima. Marstenacisside F1 inhibits lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells and is a derivative of Tenacigenin B.

ent-16β,17-Dihydroxykauran-19-oic acid	Terpenoids Diterpenoids Plants Compositae Tephrosia candida DC. Source Classification	Others
ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

(E/Z)-Flavokawain B (E/Z)-Flavokavain B	Structural Classification Monophenols Sarcandra glabra (Thunb.) Nakai Phenols Chloranthaceae Plants Source Classification	Drug Derivative
(E/Z)-Flavokawain B (compound 4) is a chalcone and nitric oxide production inhibitor with an IC₅₀ of 6.8 μM.(E/Z)-Flavokawain B can be found in the aerial parts of Sarcandra glabra.(E/Z)-Flavokawain B inhibits lipopolysaccharide-induced nitric oxide production .

(-)-3-[2-(Acetyloxy)propyl]-2-hydroxy-8-methoxy-1,4-naphthoquinone	Quinones Structural Classification Iridaceae Eleutherine plicata Herb. Plants Naphthalene Quinones Source Classification	Others
(-)-3--2-hydroxy-8-methoxy-1,4-naphthoquinone (Compound 1) is a naphthoquinone compound. (-)-3--2-hydroxy-8-methoxy-1,4-naphthoquinone is isolated from the bulbs of Eleutherine americana. (-)-3--2-hydroxy-8-methoxy-1,4-naphthoquinone shows no activity against lipopolysaccharide-induced nitric oxide production .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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lipopolysaccharide-induced nitric oxide production

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